Abstract:
:Tissue culture techniques were used to study the effect of hyperthermia on several cell types, including normal liver and hepatoma cells, as well as cell lines that have been established in culture for many years. Short exposures (less than 30 min.) at 45 degrees C readily kill a large proportion of cells. The response to heat was strikingly similar in all cells tested, and no preferential killing of neoplastic cells could be demonstrated. By contrast, hypoxic cells were found to be dramatically more susceptible to killing by heat than aerated cells. This is the reverse of the situation for x irradiation. The effectiveness of x irradiation was potentiated by treating the irradiated cells for 20 min. at 43 degrees C, which did not kill a detectable number of cells.
journal_name
Radiologyjournal_title
Radiologyauthors
Harisiadis L,Hall EJ,Kraljevic U,Borek Cdoi
10.1148/117.2.447subject
Has Abstractpub_date
1975-11-01 00:00:00pages
447-52issue
2eissn
0033-8419issn
1527-1315journal_volume
117pub_type
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