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Polarographic determination of phenytoin and benzophenone (as impurity) in pharmaceutical preparations.

Abstract：

:A differential pulse polarographic method is described for detection and trace determination of benzophenone (the main impurity) in phenytoin powder. The method depends upon the polarographic activity of benzophenone in Britton-Robinson buffer pH 5.6. The limit of detection was found to be 2.5 x 10(-6) microg ml(-1). Phenytoin has been analysed polarographically after oxidation with alkaline permanganate to give benzophenone; the limit of detection was found to be 6 x 10(-6) microg ml(-1).

journal_name

J Pharm Biomed Anal

journal_title

Journal of pharmaceutical and biomedical analysis

authors

Razak OA,Gazy AA,Wahbi AM

doi

10.1016/s0731-7085(01)00669-0

subject

Has Abstract

pub_date

2002-05-15 00:00:00

pages

613-9

issue

3-4

eissn

0731-7085

issn

1873-264X

pii

S0731708501006690

journal_volume

28

pub_type

杂志文章

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