Abstract:
INTRODUCTION:Living conditions (e. g. domestic crowding) may influence the infection rate. Some studies suggested that the reappearance of H. pylori in H. pylori positive patients after successful eradication therapy might be a result of transmission by H. pylori positive spouses. Therefore this study has been performed to evaluate the effect of the H. pylori status of family members on the reinfection rate of H. pylori positive patients after successful eradication therapy. METHODS:108 H. pylori positive patients (64 male, 44 female, aged 48.7 years, range 18-76 years) who presented with dyspeptic symptoms for upper GI-endoscopy have been included into this study. H. pylori status has been defined by culture and/or histology, rapid urease test and serology. For eradication therapy patients received omeprazole 20 mg bd, clarithromycine 250 mg bd and metronidazole 400 mg bd. H. pylori status was controlled by (13)C-urea breath test 28 days (n = 96), 6 (n = 35), 12 (n = 28) and 24 months (n = 25) after eradication therapy. Additionally H. pylori status of 170 family members (82 spouses, 68 children, 20 siblings/parents, aged 3-83 years) was defined by (13)C-urea breath test (n = 167), upper GI-endoscopy (n = 2) or serology (n = 1). RESULTS:The eradication rate was 98 % (94/96). H. pylori prevalence in all family members was 40 % (56 % in spouses, 20 % in children). No reinfection has been found in successful eradicated patients within the two-years follow-up. DISCUSSION:These results suggest that reinfection is not dependent on the H. pylori prevalence in family members and that H. pylori reinfection after successful eradication therapy is an unlikely event.
journal_name
Z Gastroenteroljournal_title
Zeitschrift fur Gastroenterologieauthors
Knippig C,Arand F,Leodolter A,Nilius M,Bayerdörffer E,Klein U,Malfertheiner Pdoi
10.1055/s-2002-32128subject
Has Abstractpub_date
2002-06-01 00:00:00pages
383-7issue
6eissn
0044-2771issn
1439-7803journal_volume
40pub_type
杂志文章abstract::In Western societies roughly 50% of all cases of liver cirrhosis are related to alcohol abuse. The oxidative metabolite of ethanol, acetaldehyde, often in conjunction with viral or metabolic liver disease, is implicated as the major cause for liver fibrogenesis. Acetaldehyde damages cell membranes, initiates lipid per...
journal_title:Zeitschrift fur Gastroenterologie
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abstract::Case-report of a 54 year-old patient who was admitted with the clinical picture of an acute abdomen on the basis of intraabdominal haemorrhage. X-ray investigation discounted the diagnosis of ruptured aortic aneurysm, the CAT scan showed a suspected acute haemorrhagic necrotising pancreatitis. At laparotomy, a fatty, ...
journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
pub_type: 杂志文章
doi:
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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journal_title:Zeitschrift fur Gastroenterologie
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