当前位置： SCI文献检索 > JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS期刊下所有文献 > Separation of tricyclic antidepressants by capillary zone electrophoresis with N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as an effective electrolyte additive.

Separation of tricyclic antidepressants by capillary zone electrophoresis with N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as an effective electrolyte additive.

Abstract：

:Five tricyclic antidepressants (TADs), desipramyne, nortriptyline, imipramine, doxepin and amitriptyline, were separated by using the N,N,N',N'-tetramethyl-1,3-butanediamine (TMBD) as additive in the background electrolyte solution. Because the tricyclic antidepressants are similar in structure, mass and pka values, their separation, by capillary zone electrophoresis, requires the careful manipulation of parameters, such as the pH and the composition of the electrolyte solution. As basic drugs, the TADs interact with the silanol groups on the capillary wall giving rise to peak broadening and asymmetry, non reproducible migration times and failing in selectivity. Different concentrations of TMBD (40, 60, 100 and 150 mM) were used at pH 9.5, but only a 100 mM TMBD allowed a good separation and a high efficiency for all the TADs. At this pH the separation was not possible without additive. This result is due to the reduced electroosmotic flow whose mobility is at a value of 10(-9) m(2) V(-1) s(-1).

journal_name

J Pharm Biomed Anal

journal_title

Journal of pharmaceutical and biomedical analysis

authors

Dell'Aquila C

doi

10.1016/s0731-7085(02)00319-9

subject

Has Abstract

pub_date

2002-09-05 00:00:00

pages

341-50

issue

2

eissn

0731-7085

issn

1873-264X

pii

S0731708502003199

journal_volume

30

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS文献大全
  • Microbiological assay for azithromycin in pharmaceutical formulations.

    abstract：:The validation of a microbiological assay, applying the cylinder-plate method, for the determination of the antibiotic azithromycin is described. Using a strain of Micrococcus luteus ATCC 9341 as the test organism, azithromycin at concentrations ranging from 0.1 to 0.4 microgml(-1) could be measured in capsules and su...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(02)00213-3

    authors： Breier AR,Garcia CV,Oppe TP,Steppe M,Schapoval EE

    更新日期：2002-07-31 00:00:00

  • Development of sub-micron patterned carbon electrodes for immunoassays.

    abstract：:Sub-micron sized domains of a carbon surface are derivatized with antibodies using biotin/avidin technology. These sites are spatially-segregated from, and directly adjacent to, electron transfer sites on the same electrode surface. The distance between these electron transfer sites and enzyme-loaded domains are kept ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(98)00292-1

    authors： Dontha N,Nowall WB,Kuhr WG

    更新日期：1999-02-01 00:00:00

  • Characterization of degradation products of amorphous and polymorphic forms of clopidogrel bisulphate under solid state stress conditions.

    abstract：:The present study deals with the stress degradation studies on amorphous and polymorphic forms of clopidogrel bisulphate. The objective was to characterize the degradation products and postulate mechanism of decomposition of the drug under solid state stress conditions. For that, amorphous form, polymorph I and polymo...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2009.05.001

    authors： Raijada DK,Prasad B,Paudel A,Shah RP,Singh S

    更新日期：2010-07-08 00:00:00

  • Determination of vitamin B6 in pharmaceutical formulations by flow injection-solid phase spectrophotometry.

    abstract：:In this work, a new solid phase spectrophotometric method in association with flow injection analysis for Vitamin B6 (pyridoxine) determination has been developed with direct measurement of light-absorption in C18 material. In the developed method, successive passage of the complex, previously formed in the flowing st...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(03)00589-2

    authors： Portela JG,Costa AC,Teixeira LS

    更新日期：2004-02-18 00:00:00

  • Ionic liquid-based ultrasound-assisted extraction and aqueous two-phase system for analysis of caffeoylquinic acids from Flos Lonicerae Japonicae.

    abstract：:In this work, an ionic liquid-based ultrasonic-assisted extraction (ILUAE) method was developed to extract caffeoylquinic acids (CQAs) from Flos Lonicerae Japonicae (FLJ). ILUAE parameters were optimized by response surface methodology, including IL concentration, ultrasonic time, and liquid-solid ratio. Optimized ILU...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2015.12.019

    authors： Tan T,Lai CJ,OuYang H,He MZ,Feng Y

    更新日期：2016-02-20 00:00:00

  • A direct LC/MS/MS method for the determination of ciclopirox penetration across human nail plate in in vitro penetration studies.

    abstract：:Due to severe chelating effect caused by N-hydroxylpyridone group of ciclopirox, there is no published direct HPLC or LC/MS/MS method for the determination of ciclopirox in any in vitro or in vivo matrix. Instead, the time-consuming pre-column derivatization methods have been adapted for indirect analysis of ciclopiro...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2009.08.019

    authors： Bu W,Fan X,Sexton H,Heyman I

    更新日期：2010-01-05 00:00:00

  • An HPLC chromatographic reactor approach for investigating the hydrolytic stability of a pharmaceutical compound.

    abstract：:The solution-phase hydrolysis kinetics of the Aprepitant (Emend) prodrug, Fosaprepitant Dimeglumine, were investigated using an HPLC chromatographic reactor approach. The term 'chromatographic reactor' refers to the use of an analytical-scale column as both a flow-through reactor and, simultaneously, as separation med...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2006.02.005

    authors： Skrdla PJ,Abrahim A,Wu Y

    更新日期：2006-06-07 00:00:00

  • Adduct ion-targeted qualitative and quantitative analysis of polyoxypregnanes by ultra-high pressure liquid chromatography coupled with triple quadrupole mass spectrometry.

    abstract：:Polyoxypregnane and its glycosides (POPs) are frequently present in plants of Asclepiadaceae family, and have a variety of biological activities. There is a great need to comprehensively profile these phytochemicals and to quantify them for monitoring their contents in the herbs and the biological samples. However, PO...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.06.038

    authors： Wu X,Zhu L,Ma J,Ye Y,Lin G

    更新日期：2017-10-25 00:00:00

  • Bead injection spectroscopy-flow injection analysis (BIS-FIA): an interesting tool applicable to pharmaceutical analysis. Determination of promethazine and trifluoperazine.

    abstract：:A bead injection spectroscopy-flow injection analysis (BIS-FIA) system for the spectrophotometric detection of promethazine and trifluoperazine is developed. The sensor is based in the oxidation of the phenothiazines by Fe(III) which is later determined by formation of the complex between Fe(II) and Ferrozine, [FeFz(3...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2004.03.010

    authors： Ruedas Rama MJ,Ruiz Medina A,Molina Díaz A

    更新日期：2004-09-03 00:00:00

  • Chemical reactivity of the naproxen acyl glucuronide and the naproxen coenzyme A thioester towards bionucleophiles.

    abstract：:Drugs may be metabolised to reactive electrophilic species that spontaneously react with proteins. The presence of such drug-protein adducts has been associated with drug toxicity. In this study, the reactivity of the major metabolite of naproxen--the 1-beta-O-glucuronide (Nap-GlcU)--was compared to the corresponding ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(02)00026-2

    authors： Olsen J,Bjørnsdottir I,Tjørnelund J,Honoré Hansen S

    更新日期：2002-06-20 00:00:00

  • Metabolites characterization of a novel DPP-4 inhibitor, imigliptin in humans and rats using ultra-high performance liquid chromatography coupled with synapt high-resolution mass spectrometry.

    abstract：:Imigliptin has been reported as a novel dipeptidyl-peptidase-IV (DPP-4) inhibitor to treat type 2 Diabetes Mellitus (T2DM), and is currently being tested in clinical trials. In the first human clinical study, imigliptin was well tolerated and proved to be a potent DPP-4 inhibitor. Considering its potential therapeutic...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jpba.2018.05.029

    authors： Liu Y,Yao X,Song L,Liu H,Zhao Q,Jiang J,Ni G,Shi C,Ma X,Zhou H,Liu D,Hu P

    更新日期：2018-08-05 00:00:00

  • Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase.

    abstract：:A reversed phase high-performance liquid chromatographic method has been developed for the determination of the R- and S-enantiomers of ibuprofen, flurbiprofen, ketoprofen and tiaprofenic acid. Separation has been achieved using a tris(4-methylbenzoate)cellulose phase after derivatization into their amides. Flurbiprof...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/0731-7085(94)e0012-p

    authors： Van Overbeke A,Baeyens W,Van den Bossche W,Dewaele C

    更新日期：1994-07-01 00:00:00

  • LC separation of calcipotriol from its photodegradation products and protection possibilities using adjuvants.

    abstract：:Mobile phase optimization and reversed-phase column characteristics were used to separate photodegradation products from the parent compound, 24-cyclopropyl-9-,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol (calcipotriol). Separation between calcipotriol and its degradation products was obtained with an ace...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(01)00390-9

    authors： Cirunay JJ,Vander Heyden Y,Plaizier-Vercammen J

    更新日期：2001-08-01 00:00:00

  • Comparison of liquid chromatography and capillary electrophoresis methods for quantification of sodium residuals.

    abstract：:Liquid chromatography (LC) and capillary electrophoresis (CE) methods were developed to perform the determination of residual sodium in mother liquors and successive washes of an active pharmaceutical ingredient (API). The addition of sodium chloride to the product solution results in rapid and complete crystallizatio...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2006.07.020

    authors： Briône W,Herbots C,Köttgen C,Loix S,Gibella M,Bertrand M,Ceccato A

    更新日期：2007-07-27 00:00:00

  • Analysis of phosphodiesterase type 5 inhibitors as possible adulterants of botanical-based dietary supplements: extensive survey of preparations available at the Czech market.

    abstract：:Popularity of natural-based preparations supporting the sexual potency significantly increased in recent years, which also led to the increase of illegal use of phosphodiesterase type 5 inhibitor (PDE-5) in sexual performance enhancement products. In this study, a rapid U-HPLC‒HRMS/MS method has been developed to simu...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2018.11.007

    authors： Jiru M,Stranska-Zachariasova M,Dzuman Z,Hurkova K,Tomaniova M,Stepan R,Cuhra P,Hajslova J

    更新日期：2019-02-05 00:00:00

  • Differential coulometry based on dual screen-printed strips for high accuracy levodopa determination towards Parkinson's disease management.

    abstract：:As a vital therapeutic agent for Parkinson's disease, dosage control of levodopa has always been a major obstacle in ensuring efficacy and curbing side effects. Simple and fast electrochemical detection methods are the main force in this field. Here, we presented a differential dual-strip method based on the coulometr...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2020.113498

    authors： Yu C,Cao Q,Tu T,Cai Y,Fang L,Ye X,Liang B

    更新日期：2020-10-25 00:00:00

  • A validated HPLC assay for salmon calcitonin analysis. Comparison of HPLC and biological assay.

    abstract：:A high-performance liquid chromatographic (HPLC) method is described for the assay of salmon calcitonin. The method uses a 5-microns octadecasilyl silica column (100 x 4.6 mm) at 50 degrees C and an initial mobile phase (flow rate 1 ml min-1) comprising 35% of B (1 M tetramethylammonium hydroxide-water-acetonitrile, 8...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/0731-7085(90)80118-9

    authors： Buck RH,Maxl F

    更新日期：1990-01-01 00:00:00

  • Authentication of Eleutherococcus and Rhodiola herbal supplement products in the United Kingdom.

    abstract：:Siberian ginseng (Eleutherococcus senticosus, Araliaceae) and roseroot (Rhodiola rosea, Rosaceae) are popular herbal supplements which have been shown to improve resilience to conditions such as stress and exhaustion. Using DNA barcoding methods we tested 25 Siberian ginseng and 14 roseroot products which are widely a...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.11.025

    authors： Ruhsam M,Hollingsworth PM

    更新日期：2018-02-05 00:00:00

  • Fast simultaneous quantitative analysis of FTY720 and its metabolite FTY720-P in human blood by on-line solid phase extraction coupled with liquid chromatography-tandem mass spectrometry.

    abstract：:Fingolimod (Gilenya; FTY720), has been recently approved for the treatment of multiple sclerosis in Europe and in the USA. In the present study, we have developed and validated a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to simultaneously quantify FTY720 and FTY720-P in human...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2011.09.021

    authors： Emotte C,Deglave F,Heudi O,Picard F,Kretz O

    更新日期：2012-01-25 00:00:00

  • Simultaneous determination of salicylic acid and acetylsalicylic acid in aspirin delayed-release tablet formulations by second-derivative UV spectrophotometry.

    abstract：:A rapid, simple assay procedure was developed for simultaneous analysis of aspirin (ASA) and salicylic acid (SA) in aspirin delayed-release tablet formulation by 'zero crossing' second-derivative UV spectrophotometry. The zero-order absorption spectra and second derivative spectra of ASA and SA were recorded in diluti...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(98)00225-8

    authors： Kokot Z,Burda K

    更新日期：1998-12-01 00:00:00

  • Design and synthesis of a theophylline bonded-phase column for HPLC--application to separation of aromatic carboxylic acids.

    abstract：:A stationary phase has been designed and synthesized in which theophylline residues are covalently bonded to a silica support through an eight carbon hydrocarbon linkage. The phase offers improved resolution in the separation of aromatic carboxylic acids over that available with conventional reversed phase supports. T...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/0731-7085(87)80055-9

    authors： Apfel M,Sternson LA,Repta AJ,Mills D

    更新日期：1987-01-01 00:00:00

  • Towards functional characterization of excipients for oral solid dosage forms using UV-vis imaging. Liberation, release and dissolution.

    abstract：:The purpose of this study was to investigate whole-dosage form UV-vis imaging as a potential tool for functional characterization of excipients used in solid oral dosage forms. To this end, tablets (average mass 260.0 mg, 224.5 mg and 222.1 mg) containing theophylline anhydrate (20 % w/w), 1% (w/w) magnesium stearate,...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2020.113789

    authors： Li Z,Sun Y,Bar-Shalom D,Mu H,Larsen SW,Jensen H,Østergaard J

    更新日期：2021-02-05 00:00:00

  • Fluorimetric and spectrophotometric determination of ritodrine hydrochloride in bulk and pharmaceutical formulations.

    abstract：:Two simple sensitive and accurate methods have been developed for the determination of ritodrine hydrochloride in bulk and pharmaceutical preparations. The first method involves the direct measurement of the native fluorescence of the drug in the concentration range 4-9 microg ml(-1), the second method is based on the...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(98)00093-4

    authors： Razak OA

    更新日期：1998-11-01 00:00:00

  • Development and validation of LC-MS/MS method for the detection and quantification of CpG oligonucleotides 107 (CpG ODN107) and its metabolites in mice plasma.

    abstract：:CpG oligodeoxynucleotide 107 (CpG ODN107) could be used as a novel radiosensitizer for glioma. Herein, a novel and sensitive reversed-phase HPLC coupled with electrospray triple quadrupole mass spectrometry (LC-MS/MS) following a one-step C18 solid-phase extraction (SPE) for biological matrix removal was developed and...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2012.06.022

    authors： Cen Y,Li X,Liu D,Pan F,Cai Y,Li B,Peng W,Wu C,Jiang W,Zhou H

    更新日期：2012-11-01 00:00:00

  • High-throughput determination of mono- and di(2-ethylhexyl)phthalate migration from PVC tubing to drugs using liquid chromatography-tandem mass spectrometry.

    abstract：:The risk assessment of di(2-ethylhexyl) phthalate (DEHP) that migrated from polyvinyl chloride (PVC) medical devices is an important issue for hospitalized patients. Many studies have been conducted to determine the level of DEHP migration. A recent report has indicated that DEHP in blood bags was hydrolyzed by estera...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2005.06.016

    authors： Ito R,Seshimo F,Miura N,Kawaguchi M,Saito K,Nakazawa H

    更新日期：2005-10-04 00:00:00

  • Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract.

    abstract：:Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes. Phyllanthus niruri has been used as a treatment for diabetes mellitus. Herein, the induction of type 2 diabetes in Sprague-Dawl...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2016.06.003

    authors： Mediani A,Abas F,Maulidiani M,Khatib A,Tan CP,Ismail IS,Shaari K,Ismail A,Lajis NH

    更新日期：2016-09-05 00:00:00

  • Hydrolytic degradation of nitrendipine and nisoldipine.

    abstract：:The development of a new HPLC-UV diode array procedure applied to follow the hydrolytic degradation of two well-known 4-nitrophenyl-1,4-dihydropyridine derivatives, nitrendipine and nisoldipine is reported. Hydrolysis of each drug were carried out in ethanol/Britton-Robinson buffer at different pHs, stored into amber ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(01)00703-8

    authors： Alvarez-Lueje A,Sturm J,Squella JA,Núñez-Vergara LJ

    更新日期：2002-06-01 00:00:00

  • Preconcentration and determination of ultra-traces of platinum in human serum using the combined electrodeposition-electrothermal atomic absorption spectroscopy (ED-ETAAS) and chemometric method.

    abstract：:Platinum compounds, including cis-dichlorodiaminoplatinum(II) or cisplatin, are an important class of anti-cancer drugs, which should be carefully monitored in the biological fluids. In this study, electrodeposition coupled with electrothermal atomic absorption spectrometry (ETAAS) was used for determination of Pt con...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2010.02.023

    authors： Najafi NM,Shahparvizi S,Rafati H,Ghasemi E,Alizadeh R

    更新日期：2010-09-21 00:00:00

  • Quantitative three-dimensional analysis of poly (lactic-co-glycolic acid) microsphere using hard X-ray nano-tomography revealed correlation between structural parameters and drug burst release.

    abstract：:The objective of this study was to investigate the use of transmission hard X-ray nano-computed-tomography (nano-CT) for characterization of the pore structure and drug distribution in poly (lactic-co-glycolic acid) (PLGA) microspheres encapsulating bovine serum albumin and to study the correlation between drug distri...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2015.04.017

    authors： Huang X,Li N,Wang D,Luo Y,Wu Z,Guo Z,Jin Q,Liu Z,Huang Y,Zhang Y,Wu C

    更新日期：2015-08-10 00:00:00

  • Preparation of a cimetidine ion-selective electrode and its application to pharmaceutical analysis.

    abstract：:A novel cimetidine ion-selective electrode is prepared, characterized and used in pharmaceutical analysis. The electrode incorporates PVC-membrane with cimetidine-phospohotungstate ion pair complex. The electrode exhibits a Nernstian response for cimetidine in the concentration range 1.0 x 10(-5)-1.0 x 10(-2) M with a...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(01)00501-5

    authors： Shamsipur M,Jalali F,Haghgoo S

    更新日期：2002-03-01 00:00:00