Extracorporeal membrane oxygenation in piglets using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201).

Abstract:

PURPOSE:The purpose of this study was to determine if the polymerized bovine hemoglobin-based oxygen-carrying solution HBOC-201 is an acceptable substitute for blood in a healthy porcine, extracorporeal membrane oxygenation (ECMO) model. METHODS:Ten piglets (15 to 25 kg) were placed on venoarterial ECMO. Four animals received blood-primed ECMO, and 6 animals received HBOC-201-primed ECMO. Hemodynamic variables, urine output, blood gas analyses, complete blood counts, and lactate levels were followed for 6 hours. Data were analyzed using a nonparametric sign test and repeated measures analysis of variance (ANOVA). RESULTS:All animals survived the 6-hour ECMO procedure. Heart rate, mean arterial pressure, urine output, and serum lactate levels were not significantly different between groups. Postpriming volume was 176 +/- 156 mL in the blood group. None of the animals in the HBOC-201 group required additional volume to maintain target flow during ECMO (P <.05). Arterial pH, pO2, and oxygen content between groups were not significantly different. Hematocrit for the HBOC-201 group was significantly (P <.05) lower than the blood group. CONCLUSIONS:HBOC-201-primed ECMO in a healthy porcine model showed similar hemodynamics and equivalent oxygen carrying capacity to blood-primed ECMO. Postpriming volume requirement was decreased significantly in the HBOC group. ECMO using HBOC-201 instead of blood appears promising and warrants further investigation.

journal_name

J Pediatr Surg

authors

York GB,DiGeronimo RJ,Wilson BJ,Cofer BR,Breuer CK,Josephs JD,Smith DL,Sorrells DL

doi

10.1053/jpsu.2002.35374

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

1387-92

issue

10

eissn

0022-3468

issn

1531-5037

pii

S0022346802001094

journal_volume

37

pub_type

杂志文章
  • Management of perforated appendicitis in children: a decade of aggressive treatment.

    abstract::Perforated appendicitis in children continues to be associated with significant morbidity. In 1976, a treatment algorithm was begun at the authors' institution, which included immediate appendectomy, antibiotic irrigation of the peritoneal cavity, transperitoneal drainage through the wound, and 10-day treatment with i...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(94)90294-1

    authors: Lund DP,Murphy EU

    更新日期:1994-08-01 00:00:00

  • Iatrogenic esophageal perforation in children: patterns of injury, presentation, management, and outcome.

    abstract::Iatrogenic esophageal perforations in children are rare. To evaluate patterns of injury, clinical presentation, and treatment options for such patients, the authors reviewed the case records of 11 children who had sustained transmural injury to the esophagus during a dilatation procedure at their institution between 1...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(96)90404-2

    authors: Panieri E,Millar AJ,Rode H,Brown RA,Cywes S

    更新日期:1996-07-01 00:00:00

  • Transumbilical laparotomy in infants: a novel approach for a wide variety of surgical disease.

    abstract:BACKGROUND/PURPOSE:Laparoscopy has kindled an interest in minimally invasive surgery in infants. To combine improved cosmesis with the advantages of open exposure, we adopted the transumbilical approach for laparotomy in babies up to 26 months of age. METHODS:Only hemodynamically stable babies were considered candidat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(03)00131-3

    authors: Soutter AD,Askew AA

    更新日期:2003-06-01 00:00:00

  • Neonatal chylothorax: a report and discussion of nine consecutive cases.

    abstract::We here report the clinical findings and management of 9 consecutive cases of chylothorax, 5 of which occurred spontaneously. One cases followed cardiac surgery. Three cases occurred in low-birth-weight, premature infants concurrently with other symptoms of the superior vena cava syndrome secondary to central intraven...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(80)80133-3

    authors: Vain NE,Swarner OW,Cha CC

    更新日期:1980-06-01 00:00:00

  • Validation of a venous thromboembolism prediction algorithm for pediatric trauma: A national trauma data bank (NTDB) analysis.

    abstract:PURPOSE:We sought to validate a risk model to predict venous thromboembolism (VTE) in pediatric trauma through an analysis of a contemporary cohort in the National Trauma Data Bank (NTDB). STUDY DESIGN:Prospective internal validation was performed in 10 randomly stratified samples of children (age 0-17 years) from the...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2020.02.032

    authors: Cunningham AJ,Dewey E,Hamilton NA,Schreiber MA,Krishnaswami S,Jafri MA

    更新日期:2020-06-01 00:00:00

  • Chest tube placement in children during extracorporeal membrane oxygenation (ECMO).

    abstract:BACKGROUND:Pleural collections of air and fluid are frequent in infants and children treated with extracorporeal membrane oxygenation (ECMO). In this anticoagulated population, chest tube placement is potentially hazardous, and catastrophic hemorrhage has been reported. We sought to define the risks associated with che...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.jpedsurg.2013.09.028

    authors: Jackson HT,Longshore S,Feldman J,Zirschky K,Gingalewski CA,Gollin G

    更新日期:2014-01-01 00:00:00

  • Understanding translational research: a play in four acts.

    abstract::Translational research (TR) bridges discovery to clinical delivery. All TR also requires the development of an intervention. Classical 'bench to bedside' TR is responsible for many important advances, but cannot account for many others, which begin with clinical observations. My personal involvement in TR has ranged f...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2014.10.023

    authors: Rose EA

    更新日期:2015-01-01 00:00:00

  • Unilateral leg edema caused by abdominoscrotal hydrocele: elegant diagnosis by MRI.

    abstract::A 5-month-old boy presented with bilateral hydroceles since birth and right leg edema. An ultrasound of the pelvis showed a 4-cm cystic mass that was diagnosed as a teratoma or cystic hygroma. Magnetic resonance imaging was performed, which showed a dumbbell shaped contiguous, fluid filled mass extending intraabdomina...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/0022-3468(92)90295-i

    authors: Krasna IH,Solomon M,Mezrich R

    更新日期:1992-10-01 00:00:00

  • Fetal tissue engineering: chest wall reconstruction.

    abstract:BACKGROUND/PURPOSE:This study was aimed at applying fetal tissue engineering to chest wall reconstruction. METHODS:Fetal lambs underwent harvest of elastic and hyaline cartilage specimens. Once expanded in vitro, fetal chondrocytes were seeded onto synthetic scaffolds, which then were placed in a bioreactor. After bir...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(03)00265-3

    authors: Fuchs JR,Terada S,Hannouche D,Ochoa ER,Vacanti JP,Fauza DO

    更新日期:2003-08-01 00:00:00

  • Mycobacterial lymphadenitis.

    abstract::The plan for cervical lymph node biopsy should include special maneuvers for recognition of patients with lymphadenitis due to atypical mycobacteria, since these children need extensive operations. The diagnosis should be suspected in children less than 3 yr old with lymphadenopathy present for several months and no e...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(82)80116-4

    authors: Harris BH,Webb HW,Wilkinson AH Jr,Santelices AA

    更新日期:1982-10-01 00:00:00

  • Wolff-Chaikoff effect in a newborn: is it an overlooked problem?

    abstract::Hypothyroidism is a serious endocrine disorder emerging from deficient production of thyroid hormone (thyroid gland agenesis or dysgenesis, or inborn metabolic defects of thyroid hormone production) or a defect in thyroid hormonal receptor activity. Prevention of iodine organification by means of using iodine-containi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2006.08.041

    authors: Aliefendioğlu D,Sanli C,Cakmak M,Ağar A,Albayrak M,Evliyaoğlu O

    更新日期:2006-12-01 00:00:00

  • Duodenal duplication cyst manifested by duodeno-jejunal intussusception and hyperbilirubinemia.

    abstract::A rare case of duodenal duplication cyst containing stones in a 17-year-old patient is presented. The cyst, acting as a leading point for duodeno-jejunal intussusception caused proximal small bowel obstruction and hyperbilirubinemia. Preoperative diagnosis was based on abdominal computerized tomography. At operation, ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90176-8

    authors: Zamir G,Gross E,Shmushkevich A,Bar-Ziv J,Durst AL,Jurim O

    更新日期:1999-08-01 00:00:00

  • Making the diagnosis of midgut volvulus: Limited abdominal ultrasound has changed our clinical practice.

    abstract:PURPOSE:To assess the diagnostic accuracy of limited abdominal ultrasound (US) examination for midgut volvulus (MGV) and to evaluate how clinical practice has changed in a free-standing children's hospital leading to the near obsolescence of upper GI (UGI) studies for the diagnosis of MGV. MATERIALS AND METHODS:All pa...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2020.04.012

    authors: Wong K,Van Tassel D,Lee J,Buchmann R,Riemann M,Egan C,Youssfi M

    更新日期:2020-12-01 00:00:00

  • Assessment and comparison of fecal continence in children following primary posterior sagittal anorectoplasty and abdominoperineal pull through for anorectal anomaly using clinical scoring and MRI.

    abstract:INTRODUCTION:We aimed to compare and contrast these main surgical procedures for ARM in terms of structural outcome through pelvic MRI & functional outcome through Kelly's scoring. MATERIAL AND METHOD:A prospective study was conducted from August 2011 to July 2013 including all the cases of ARM managed in single stage...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jpedsurg.2015.09.003

    authors: Gangopadhyay AN,Pandey V,Gupta DK,Sharma SP,Kumar V,Verma A

    更新日期:2016-03-01 00:00:00

  • Regional reduction in intestinal neuroendocrine cell populations in enterocolitis complicating Hirschsprung's disease.

    abstract::Enterocolitis (EC) remains the most serious complication of Hirschsprung's disease (HD). The aetiology of EC is uncertain. Ischemic and bacterial causes, and recently rotavirus infection, have been suggested to explain the occurrence of EC. The gut has an abundance of neuroendocrine (NE) cells which modulate gut funct...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90520-u

    authors: Soeda J,O'Briain DS,Puri P

    更新日期:1993-08-01 00:00:00

  • Citrulline levels following proximal versus distal small bowel resection.

    abstract:PURPOSE:Citrulline, a nonprotein amino acid synthesized by enterocytes, is a biomarker of bowel length and the capacity to wean from parenteral nutrition. However, the potentially variant effect of jejunal versus ileal excision on plasma citrulline concentration [CIT] has not been studied. This investigation compared s...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2014.02.056

    authors: Gutierrez IM,Fisher JG,Ben-Ishay O,Jones BA,Kang KH,Hull MA,Shillingford N,Zurakowski D,Modi BP,Jaksic T

    更新日期:2014-05-01 00:00:00

  • Neutropenic enteropathy: a 10-year review.

    abstract:PURPOSE:With the advent of more aggressive chemotherapy, the incidence of neutropenic enteropathy is increasing. This review was performed to (1) determine which children are affected, (2) identify predisposing factors, and (3) assess efficacy of treatment. METHODS:A 10-year (1988 to 1997) review identified 33 childre...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90566-3

    authors: Baerg J,Murphy JJ,Anderson R,Magee JF

    更新日期:1999-07-01 00:00:00

  • Initial laparoscopic appendectomy versus initial nonoperative management and interval appendectomy for perforated appendicitis with abscess: a prospective, randomized trial.

    abstract:INTRODUCTION:Perforated appendicitis is a common condition in children, which, in a small number of patients, may be complicated by a well-formed abscess. Initial nonoperative management with percutaneous drainage/aspiration of the abscess followed by intravenous antibiotics usually allows for an uneventful interval ap...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jpedsurg.2009.10.039

    authors: St Peter SD,Aguayo P,Fraser JD,Keckler SJ,Sharp SW,Leys CM,Murphy JP,Snyder CL,Sharp RJ,Andrews WS,Holcomb GW 3rd,Ostlie DJ

    更新日期:2010-01-01 00:00:00

  • Liver transplantation for childhood hepatic malignancy: a review of the United Network for Organ Sharing (UNOS) database.

    abstract:BACKGROUND:Orthotopic liver transplantation (OLT) is the only treatment option for unresectable hepatoblastoma (HB) and hepatocellular carcinoma (HCC) in children. Aggregated outcomes of OLT for these hepatic malignancies have not been evaluated in the United Network for Organ Sharing national database. PURPOSE:The pu...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2005.10.091

    authors: Austin MT,Leys CM,Feurer ID,Lovvorn HN 3rd,O'Neill JA Jr,Pinson CW,Pietsch JB

    更新日期:2006-01-01 00:00:00

  • Pancreatic hydatid cyst masquerading as a choledochal cyst.

    abstract::A 6-year-old boy presented with repeated attacks of fever, abdominal pain, and obstructive jaundice. Clinical examination and preoperative imaging suggested the diagnosis of a type I choledochal cyst. During surgery, a hydatid cyst was found occupying the head of pancreas, causing obstruction of the common bile duct. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2012.07.054

    authors: Mandelia A,Wahal A,Solanki S,Srinivas M,Bhatnagar V

    更新日期:2012-11-01 00:00:00

  • Effects of rapamycin on granulation formation in response to centrally doubled coiled stents as a tracheal substitute.

    abstract:INTRODUCTION:In experiments involving tracheal wall defects in rabbits, metallic coil stents inevitably induce granulation formation in the defects. We examined the involvement of the mammalian target of rapamycin (mTOR) signaling pathway in granulation formation and examined the effects of rapamycin. METHODS:The ante...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2013.08.013

    authors: Kubota M,Matsuda Y,Fujimaki S,Osawa M,Wakai T,Nakaya K

    更新日期:2013-12-01 00:00:00

  • Comparison of transumbilical laparoscopic-assisted appendectomy versus single incision laparoscopic appendectomy in children: which is the better surgical option?

    abstract:BACKGROUND:Transumbilical laparoscopic-assisted appendectomy (TULA) is a single incision technique that exteriorizes the appendix through the umbilicus. The aim of this study was to compare the surgical outcomes of TULA with SILA in pediatric appendicitis. METHODS:A retrospective review of medical records between Apri...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2015.12.013

    authors: Boo YJ,Lee Y,Lee JS

    更新日期:2016-08-01 00:00:00

  • Morbidity and mortality among "big" babies who develop necrotizing enterocolitis: A prospective multicenter cohort analysis.

    abstract:BACKGROUND:Necrotizing enterocolitis (NEC) is classically a disease of prematurity, with less reported regarding morbidity and mortality of this disease among other infants. METHODS:Data were prospectively collected from 2009 to 2015 at 252 Vermont Oxford Network member centers on neonates with birth weight>2500g admi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2017.10.028

    authors: Velazco CS,Fullerton BS,Hong CR,Morrow KA,Edwards EM,Soll RF,Jaksic T,Horbar JD,Modi BP

    更新日期:2017-10-12 00:00:00

  • Treatment of intraosseous arteriovenous fistulas of the extremities.

    abstract::Intraosseous arteriovenous fistulas of the extremities are rare malformations frequently associated with severe systemic hemodynamic alterations. In many cases, it is quite difficult to eliminate these anomalous vascular structures, but the possibilities for successful treatment are much greater when surgery is combin...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(94)90120-1

    authors: Perrelli L,Cina G,Cotroneo AR,Falappa P,Nanni L

    更新日期:1994-10-01 00:00:00

  • Sibling occurrence of biliary atresia and biliary dilatation.

    abstract::Familial occurrence of extrahepatic biliary atresia (EHBA) or biliary dilatation has been reported; however, the genetic influences on these disorders are still obscure. The authors previously reported the occurrence of biliary dilatation and EHBA in sisters, which is extremely rare. Recently, a similar pair of sister...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(96)90259-6

    authors: Ando K,Miyano T,Fujimoto T,Ohya T,Lane G,Tawa T,Tokita A,Yabuta K

    更新日期:1996-09-01 00:00:00

  • A proposal to preserve the ileocecal valve and right colon in total colonic aganglionosis.

    abstract::We report two cases of total colonic aganglionosis in which the ileocecal valve and right colon were preserved. The aganglionic ileal segment is removed leaving behind only a very short prececal remnant, which is anastomosed end-to-back to the remaining ileum. An ileal loop (of approximately 20 cm in length) is isolat...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(89)80401-4

    authors: Sauer H,Klos I

    更新日期:1989-05-01 00:00:00

  • Gastrostomy tube placement in infants and children: is there a preferred technique?

    abstract:PURPOSE:Advances in percutaneous endoscopic gastrostomy (PEG) and laparoscopic (LAP) techniques, including LAP-assisted PEG, offer alternatives to the standard open gastrostomy technique. This study compares the outcomes of the PEG and LAP techniques. METHODS:All gastrostomy tube placements were reviewed at our instit...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2010.02.079

    authors: Akay B,Capizzani TR,Lee AM,Drongowski RA,Geiger JD,Hirschl RB,Mychaliska GB

    更新日期:2010-06-01 00:00:00

  • Thoracoscopic sympathotomy for palmar hyperhidrosis: How young is too young?

    abstract:BACKGROUND/PURPOSE:Primary hyperhidrosis affects 1%-3% of the general population, with increased incidence in teenagers, having an important impact in the quality of life. This study evaluates the efficacy and patients' satisfaction after bilateral thoracoscopic sympathotomy. METHODS:Retrospective analysis of pediatri...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2019.11.024

    authors: Vasconcelos-Castro S,Soares-Oliveira M,Tuna T,Borges-Dias M

    更新日期:2020-11-01 00:00:00

  • Determining the optimal timing of liver transplant for pediatric patients after Kasai portoenterostomy based on disease severity scores.

    abstract:BACKGROUND:The objective of this study was to determine the most optimal timing of liver transplant (LT) for post-Kasai portoenterostomy (KPE) patients based on disease severity scores. METHODS:This was a retrospective study and the clinical data of all LT recipients aged <18 years (n = 89) with a history of KPE were ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2019.10.016

    authors: Chung PHY,Chok KSH,Wong KKY,Tam PKH,Lo CM

    更新日期:2020-09-01 00:00:00

  • Regional analgesia for postoperative pain in pediatric outpatient surgery.

    abstract::Of 156 children undergoing elective inguinal herniotomy under general anesthesia, 81 also had a regional nerve block using Bupivacaine. All were treated as outpatients and recovery was assessed by postanesthetic room nurses and by interrogating the parents as to the child's behavior at home. It was concluded that the ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(80)80757-3

    authors: Shandling B,Steward DJ

    更新日期:1980-08-01 00:00:00