Reduction in formation and growth of 1,2-dimethylhydrazine-induced aberrant crypt foci in rat colon by docosahexaenoic acid.

abstract：:Inflammasomes are key regulators of innate immunity in chronic inflammatory disorders and autoimmune diseases, but their role in inflammation-associated tumorigenesis remains ill-defined. Here we reveal a protumorigenic role in gastric cancer for the key inflammasome adaptor apoptosis-related speck-like protein contai...

journal_title：Cancer research

authors： Deswaerte V,Nguyen P,West A,Browning AF,Yu L,Ruwanpura SM,Balic J,Livis T,Girard C,Preaudet A,Oshima H,Fung KY,Tye H,Najdovska M,Ernst M,Oshima M,Gabay C,Putoczki T,Jenkins BJ

更新日期：2018-03-01 00:00:00

abstract：:Ewing Sarcoma (ES) shows several deregulated autocrine loops mediating cell survival and proliferation. Therefore, their blockade is a promising therapeutic approach. We previously reported the in vitro effect of insulin-like growth factor 1 receptor (IGF1R)/KIT pathway blockade on ES cell lines, and we now extend our...

journal_title：Cancer research

authors： Martins AS,Ordoñez JL,García-Sánchez A,Herrero D,Sevillano V,Osuna D,Mackintosh C,Caballero G,Otero AP,Poremba C,Madoz-Gúrpide J,de Alava E

更新日期：2008-08-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although >85% of GIST patients treated with the small-molecule inhibitor imatinib mesylate (Gleevec) achieve disease stabilization, complete remissions are rare and a substantial proportion of...

journal_title：Cancer research

authors： Bauer S,Parry JA,Mühlenberg T,Brown MF,Seneviratne D,Chatterjee P,Chin A,Rubin BP,Kuan SF,Fletcher JA,Duensing S,Duensing A

更新日期：2010-01-01 00:00:00

abstract：:Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-insensitive thyroid cancer. To investigate the mechanisms underlying this resistance, we evaluated the expression of four different inhibitor of apoptosis proteins, and their antagonist, Smac, in thyroid cancer cells that survived...

journal_title：Cancer research

authors： Tirrò E,Consoli ML,Massimino M,Manzella L,Frasca F,Sciacca L,Vicari L,Stassi G,Messina L,Messina A,Vigneri P

更新日期：2006-04-15 00:00:00

abstract：:ErbB-2 (HER-2/neu) is a transforming oncogene expressed by a substantial fraction of breast cancers, and monoclonal antibody therapy directed toward this antigen is an established treatment modality. However, not all tumors respond, and with a monoclonal antibody directed to a single epitope, there is always the risk ...

journal_title：Cancer research

authors： Park JM,Terabe M,Steel JC,Forni G,Sakai Y,Morris JC,Berzofsky JA

更新日期：2008-03-15 00:00:00

abstract：:Busulfan causes long-lasting defects in the hematopoietic stem cells and in the immune system of mice. We designed studies to determine whether chloramphenicol further damaged the already defective hematopoietic stem cells of mice that were pretreated with busulfan, and we unexpectedly observed that mice given injecti...

journal_title：Cancer research

authors： Robin E,Berman M,Bhoopalam N,Cohen H,Fried W

更新日期：1981-09-01 00:00:00

abstract：:Cytokine production and cytotoxicity for tumor cells are two important aspects of monocyte function and the inflammatory response against tumors and infectious agents. In the present studies we provide direct evidence at the mRNA and protein levels for the existence of autocrine tumor necrosis factor (TNF) and its imp...

journal_title：Cancer research

authors： Smith DM,Lackides GA,Epstein LB

更新日期：1990-06-01 00:00:00

abstract：:Mitotic and labeling indices of bone marrow tumor cells were determined from patients with disseminated neuroblastoma. Although pretreatment values were variable, the median indices indicated that only a small proportion of tumor cells were proliferating. The pretreatment indices could not be correlated with presentin...

journal_title：Cancer research

authors： Hayes FA,Green AA,Mauer AM

更新日期：1977-10-01 00:00:00

abstract：:BAG-1 is a multifunctional protein that blocks apoptosis and interacts with several types of proteins, including Bcl-2 family proteins, the kinase Raf-1, certain tyrosine kinase growth factor receptors, and steroid hormone receptors, possibly by virtue of its ability to regulate the Hsp70/Hsc70 family of molecular cha...

journal_title：Cancer research

authors： Takayama S,Krajewski S,Krajewska M,Kitada S,Zapata JM,Kochel K,Knee D,Scudiero D,Tudor G,Miller GJ,Miyashita T,Yamada M,Reed JC

更新日期：1998-07-15 00:00:00

abstract：:Despite considerable efforts to improve early detection of ovarian cancer, the majority of women at time of diagnosis will have metastatic disease. Understanding and targeting the molecular underpinnings of metastasis continues to be the principal challenge in the clinical management of ovarian cancer. Whereas the mul...

journal_title：Cancer research

authors： Hickson JA,Huo D,Vander Griend DJ,Lin A,Rinker-Schaeffer CW,Yamada SD

更新日期：2006-02-15 00:00:00

abstract：:Bleomycin was administered to six patients with advanced cancer. Multiple parameters of both antibody- and cell-mediated immunity were followed serially to characterize the effects of bleomycin on immunocompetence in humans. Antibody-mediated immunity, including primary vaccination with keyhole limpet hemocyanin, was ...

journal_title：Cancer research

authors： Lehane DE,Hurd E,Lane M

更新日期：1975-10-01 00:00:00

abstract：:Despite the initial efficacy of androgen deprivation therapy, most patients with advanced prostate cancer eventually progress to hormone-refractory prostate cancer, for which there is no curative therapy. Previous studies from our laboratory and others have shown the antiproliferative and proapoptotic effects of 3,3'-...

journal_title：Cancer research

authors： Bhuiyan MM,Li Y,Banerjee S,Ahmed F,Wang Z,Ali S,Sarkar FH

更新日期：2006-10-15 00:00:00

abstract：:Two human ovarian tumor cell lines (SK-OV-3 and TR175), established from patients previously treated with alkylating agents, but not with cisplatin, expressed greater than 23-fold differences in cisplatin sensitivities in vitro. Cisplatin resistance in SK-OV-3 cells appeared to be associated with increased levels of g...

journal_title：Cancer research

authors： Shellard SA,Hosking LK,Hill BT

更新日期：1991-09-01 00:00:00

abstract：:Human mammary and other carcinoma cells secrete and express on their cell surfaces complex, mucin-like glycoproteins (Mr greater than 10(6] that are recognized as tumor-associated antigens by a variety of monoclonal antibodies (MAbs). One such MAb, B72.3, has been extensively studied as to range of reactivity for a va...

journal_title：Cancer research

authors： Sheer DG,Schlom J,Cooper HL

更新日期：1988-12-01 00:00:00

abstract：:We have studied the effects of low-power-density microwave (MW) radiation (continuous and pulsed wave with average power density of 10 milliwatts/sq cm and range of 5 to 50 milliwatts/sq cm; frequency, 1.0 GHz) on the uptake and action of methotrexate (MTX), the inhibition of DNA synthesis in L1210 murine leukemia cel...

journal_title：Cancer research

authors： Chang BK,Huang AT,Joines WT

更新日期：1980-04-01 00:00:00

abstract：:Murine sarcoma virus (Moloney strain) (MSV-M)-induced tumors are unusual in that they regularly appear less than 2 weeks after virus inoculation, progress for 1 to 2 weeks, and are rejected by normal adult BALB/c mice. Rejectio leaves the animals immune to tumor induction. In the present study, presensitization of nor...

journal_title：Cancer research

authors： Wood GW

更新日期：1976-12-01 00:00:00

abstract：:PARP-1 is a nuclear protein that has important roles in maintenance of genomic integrity. During genotoxic stress, PARP-1 recruits to sites of DNA damage where PARP-1 domain architecture initiates catalytic activation and subsequent poly(ADP-ribose)-dependent DNA repair. PARP-1 inhibition is a promising new way to sel...

journal_title：Cancer research

authors： Steffen JD,Tholey RM,Langelier MF,Planck JL,Schiewer MJ,Lal S,Bildzukewicz NA,Yeo CJ,Knudsen KE,Brody JR,Pascal JM

更新日期：2014-01-01 00:00:00

abstract：:Angiogenesis, the sprouting of new blood vessels from existing vessels, occurs in many physiological and pathological processes, including embryonic development, wound healing, and tumor growth. It is required for tumor growth because new blood vessel formation is necessary for tumors to expand beyond a minimum volume...

journal_title：Cancer research

authors： Millauer B,Longhi MP,Plate KH,Shawver LK,Risau W,Ullrich A,Strawn LM

更新日期：1996-04-01 00:00:00

abstract：:Photodynamic therapy (PDT) clinical results are promising; however, tumor recurrences can occur and, therefore, methods for improving treatment efficacy are needed. PDT elicits direct tumor cell death and microvascular injury as well as expression of angiogenic, inflammatory, and prosurvival molecules. Preclinical stu...

journal_title：Cancer research

authors： Ferrario A,Chantrain CF,von Tiehl K,Buckley S,Rucker N,Shalinsky DR,Shimada H,DeClerck YA,Gomer CJ

更新日期：2004-04-01 00:00:00

abstract：:Enhancement of specific transplantation resistance to a syngeneic tumor (KMT-17) was observed in WKA rats by treatment with the antileukemia drug busulfan (BU) (15 mg/kg) 5 days before and 5 days after immunization with X-irradiated KMT-17 tumor cells. Rats immunized with X-irradiated KMT-17 cells and then treated wit...

journal_title：Cancer research

authors： Mizushima Y,Sendo F,Takeichi N,Hosohawa M,Kobayashi H

更新日期：1981-07-01 00:00:00

abstract：:Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it is generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion is mostly correlational. In this study, we directl...

journal_title：Cancer research

authors： Grossberg AJ,Vichaya EG,Christian DL,Molkentine JM,Vermeer DW,Gross PS,Vermeer PD,Lee JH,Dantzer R

更新日期：2018-02-01 00:00:00

abstract：:An animal model to investigate the invasive and metastatic properties of human bladder transitional cell carcinoma (HTCC) was established. Two long-term HTCC cell lines (RT4 and EJ) and one HTCC cell line derived in our laboratory (LD-71) were tumorigenic when injected s.c. into nude mice but had little potential to i...

journal_title：Cancer research

authors： Ahlering TE,Dubeau L,Jones PA

更新日期：1987-12-15 00:00:00

abstract：:The frequency of H-ras, K-ras, and N-ras mutations and the presence of high-risk human papillomavirus (HPV 16, 18, and 33) DNA were studied in 75 paraffin-embedded specimens obtained from 68 Japanese patients with a variety of prostate carcinomas by using polymerase chain reaction and DNA hybridization with sequence-s...

journal_title：Cancer research

authors： Anwar K,Nakakuki K,Shiraishi T,Naiki H,Yatani R,Inuzuka M

更新日期：1992-11-01 00:00:00

abstract：:Solid tumors contain a subset of stem-like cells that are resistant to the cytotoxic effects of chemotherapy/radiotherapy, but their susceptibility to cytolytic T lymphocyte (CTL) effector mechanisms has not been well characterized. Using a panel of early-passage human brain tumor stem/initiating cell (BTSC) lines der...

journal_title：Cancer research

authors： Brown CE,Starr R,Martinez C,Aguilar B,D'Apuzzo M,Todorov I,Shih CC,Badie B,Hudecek M,Riddell SR,Jensen MC

更新日期：2009-12-01 00:00:00

abstract：:The aim of this current study was to examine the significance of CD44 expression in mediating cancer cell adhesion to human bone marrow endothelial cell(s) (hBMEC). Differential CD44 expression on two metastatic prostate cancer cell lines, PC3 (CD44 +ve) and DU145 (CD44 -ve) and four breast cancer cell lines was confi...

journal_title：Cancer research

authors： Draffin JE,McFarlane S,Hill A,Johnston PG,Waugh DJ

更新日期：2004-08-15 00:00:00

abstract：:We have examined the properties of the estrogen receptor and progesterone receptor in MDA-MB-134 human breast cells and have evaluated the effects of estrogen on cell proliferation and progesterone receptor levels in these cells as indices of hormonal sensitivity. These cells contain high levels of estrogen receptor (...

journal_title：Cancer research

authors： Reiner GC,Katzenellenbogen BS

更新日期：1986-03-01 00:00:00

abstract：:Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success la...

journal_title：Cancer research

authors： Siddiqui IA,Adhami VM,Bharali DJ,Hafeez BB,Asim M,Khwaja SI,Ahmad N,Cui H,Mousa SA,Mukhtar H

更新日期：2009-03-01 00:00:00

abstract：:Phosphorylation of heat shock protein 27 (HSP27) has been suggested to play an important role in the regulation of F-actin dynamics in response to growth factors and stress. Because the microfilament network is one of the earliest targets of oxidative stress and because phosphorylation of HSP27 is strongly induced by ...

journal_title：Cancer research

authors： Huot J,Houle F,Spitz DR,Landry J

更新日期：1996-01-15 00:00:00

abstract：:We have studied the cellular expression of NB/70K, a glycoprotein proposed to be human ovarian tumor associated described previously. Analysis of cells bearing this antigen in malignant ascites shows expression in tumor cells of gynecological origin (ovarian, endometrial) and to a limited degree in breast cancer cells...

journal_title：Cancer research

authors： Bizzari JP,Mackillop WJ,Buick RN

更新日期：1983-02-01 00:00:00

abstract：:The adoptive transfer of recombinant-methionyl human interleukin 2 (rIL-2)-activated autologous peripheral blood mononuclear lymphokine-activated killer (LAK) cells to cancer patients is being evaluated as an alternative to conventional cancer therapy. We have independently developed an alternative regimen to previous...

journal_title：Cancer research

authors： Schoof DD,Gramolini BA,Davidson DL,Massaro AF,Wilson RE,Eberlein TJ

更新日期：1988-09-01 00:00:00