Abstract:
BACKGROUND:To investigate in human and porcine isolated ciliary bodies the effect of acetazolamide and epinephrine on ciliary transepithelial ionic currents (a parameter linked to aqueous humor production). MATERIAL AND METHODS:Isolated ciliary bodies were mounted in a Ussing-type chamber to measure transepithelial potential difference (PD) and short circuit current (Isc) before and after exposure to either 100 micro M acetazolamide or 10 micro M epinephrine. RESULTS:In humans (N = 27), baseline PD was 1184 +/- 100 micro V (negative on the non-pigmented epithelial [NPE] side) and Isc 19.9 +/- 1.5 micro A/cm 2. Acetazolamide (N = 7 - 8) decreased Isc (NPE side: 8.4 +/- 1.1 micro A/cm 2; pigmented epithelial [PE] side: 7.4 +/- 0.9 micro A/cm 2) while epinephrine (N = 6) increased Isc only on the NPE side (9.9 +/- 0.8 micro A/cm 2). In pigs, baseline PD was in some preparations negative (862 +/- 84 micro V, N = 18) and in others positive (814 +/- 81 micro V, N = 10) on the NPE side with Isc 15.6 +/- 1.6 micro A/cm 2 and 16.3 +/- 2.6 micro A/cm 2, respectively. In all preparations, acetazolamide (N = 6 - 7) decreased Isc (NPE side: 6.1 +/- 0.6 micro A/cm 2; PE side: 4.8 +/- 0.3 micro A/cm 2) while epinephrine (N = 8) increased it only on the NPE side (10.5 +/- 0.6 micro A/cm 2). CONCLUSIONS:To our knowledge, this is the first time that this methodology is applied to measure transepithelial ionic currents in isolated human and porcine ciliary bodies. This method could be used to test drugs modulating aqueous humor production.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Wu R,Flammer J,Haefliger Idoi
10.1055/s-2003-38168subject
Has Abstractpub_date
2003-03-01 00:00:00pages
156-60issue
3eissn
0023-2165issn
1439-3999journal_volume
220pub_type
杂志文章abstract:BACKGROUND:The purpose of this article is to report an unusual ocular manifestation of cat scratch disease (CSD) presenting as a unilateral acute maculopathy (UAM). We describe and review the clinical, laboratory, fluorescein angiography (FA), indocyanine green angiography (ICG) and optical coherence tomography (OCT) r...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-962855
更新日期:2007-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compare the results of intraocular pressure (IOP) measurements obtained using the pressure phosphene tonometer Proview with those from Goldmann applanation tonometer (GAT) in normal and glaucomatous eyes. PATIENTS AND METHODS:The IOP in 150 eyes of 62 healthy volunteers and 88 p...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2006-927094
更新日期:2006-11-01 00:00:00
abstract::We monitored 300 patients who had undergone ambulatory cataract operations. Patients are more and more preferring this type of surgery, which allows them to go home immediately after the operation. We compare ambulatory ECCE and phacoemulsification operations and their complications, advantages and disadvantages. We s...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035536
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Intravitreal anti-VEGF therapy with Pegaptanib was effective in neovascular AMD in the VISION study. We report our experience with Macugen for the treatment of occult or minimally classic choroidal neovascularisation (CNV) due to age-related macular degeneration (AMD). PATIENTS AND METHODS:35 eyes of 35 pat...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1027474
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:Measles retinitis is rare in immunocompetent patients and has recently been only sporadically described. This case report reveals the clinical picture, the course of the disease and the prognosis of this entity. HISTORY AND FINDINGS:One month after a diagnosed measles infection, a 12-year-old girl presented...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045509
更新日期:1994-09-01 00:00:00
abstract::A recently developed sound probe (10 MHz and 3 mm diameter) is suitable for sparing preoperative localisation of foreign bodies in perforated eyes; especially mural foreign bodies can be exactly located intraoperatively. Followed scleral incision foreign bodies can be extracted on the optimal route. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Corneal blood staining may occur as a serious complication of persisting hyphema. In our two cases the corneal blood staining is a result of direct bleeding in the corneal stroma. HISTORY AND SIGNS:A female patient presented with a corneal blood staining through rupture of reopened vessels in interstitial k...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035098
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Proliferative retinopathy is an important cause of vision loss in diabetic patients. Incomplete panretinal photocoagulation (PRP) can lead to recurrent proliferation of new vessels. PATIENTS AND METHODS:We retrospectively analysed the outcome of patients with high risk proliferative diabetic retinopathy (PD...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0035-1545795
更新日期:2015-04-01 00:00:00
abstract::Trauma of the medial canthal region can affect all parts of the lacrimal ducts. Depending on the patient's age, there may be different mechanisms of injury. Surgical reconstruction using two autostable ("self-retaining") monocanaliculonasal lacrimal tubes is demonstrated by two case reports. Here, a 6 years old girl a...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0839-5172
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Incomplete removal of the viscoelastic material during cataract surgery may lead to the early postoperative capsular block syndrome. In this retrospective case series, postoperative capsular bag distention after implantation of a foldable acrylic lens is reported and the sequelae are analyzed. PATIENTS AND ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2004-812876
更新日期:2004-05-01 00:00:00
abstract:INTRODUCTION:Advances in the area of information technology have opened up new possibilities for the use of interactive media in the training of medical students. Classical instructional technologies, such as video, slides, audio cassettes and computer programs with a textbook orientation, have been merged into one mul...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract::In the EU more than 70 % of national law has already been replaced by EU law. Medical doctors are mostly not informed, how these EU-laws will pass. Many directives, regulations and decisions are important for medical doctors. A characterization of the EU- institutions is represented. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-858749
更新日期:2005-11-01 00:00:00
abstract::A report is given on three patients who noticed an acute deterioration of visual acuity after a sojourn at 5000 altitude caused by retinal hemorrhages. We documented both the ophthalmological examinations such as visual acuity, fundus, perimetry and fluorescence-angiography and the systemic results. During the period ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:In order to obtain artifact-free electro-oculogram recordings the subject's cooperation is necessary. The aim of our study is to evaluate the recording characteristics of short-duration EOG and to compare the effect of mydriasis on electro-oculogram recordings in a cohort of controls. PATIENTS AND METHODS:E...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,随机对照试验
doi:10.1055/s-0034-1396330
更新日期:2015-04-01 00:00:00
abstract::A 55-year-old man was referred to our clinic with a mature, swollen cataractous lens and a secondary phakolytic glaucoma. However, the patient refused to undergo surgery. Twelve years later he returned. Meanwhile the lens had been almost completely absorbed; visual acuity was 20/32 and there had been no severe damage...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055071
更新日期:1982-04-01 00:00:00
abstract::We report on a 35 year old patient suffering from heterochromia complicata Fuchs with a mature cataract. Multiple small whitish-yellowish crystal-lines on the iris at the 7 and 12 o'clock position were interpreted as Russell bodies and correlated with an elevated concentration of 7.2 mg/dl IgG in the aqueous humor ana...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045953
更新日期:1991-03-01 00:00:00
abstract::BACKGROUND Many peptides now identified in the brain were previously thought of as exclusively peripheral hormones. Among those, the renin-angiotensin system (RAS) is not only found to be of great importance in peripheral vasomotor and electrolyte homeostasis but also acts as neurotransmitter or modulator in the centr...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1045478
更新日期:1994-06-01 00:00:00
abstract::To reform the conjunctival sac in cases of symblepharon or when the globe is not present, various procedures and materials are used. The cornea showed itself to be suitable material for covering areas which are left naked after removing corneal adhesions. Heterotopic corneal transplantation leads to good results in th...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract:OBJECTIVE:To study the learning risk of a new surgical technique, the deep sclerectomy (DS), which may be complicated with a perforation of the trabeculodescemetic membrane. To do so, we compared the results and the complications of patients who underwent DS transformed in trabeculectomy (DSt) and those of patients who...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035050
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Photodynamic therapy (PDT) is an established treatment in predominantly classic choroidal neovascularisation (CNV) in exudative age-related macular degeneration (AMD). Membranoproliferative glomerulonephritis (MPGN) type II leads to AMD-similar changes ("pseudo-AMD") of the fundus with CNV as a late complica...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2003-40937
更新日期:2003-07-01 00:00:00
abstract::General anaesthesia was performed in 75 patients with difficult intraocular procedures in which the standard relaxation and hyperventilation was supplemented by controlled short-term hypotension by sodium-nitroprusside. This resulted in a significant decrease of the "vis a tergo"--e.g. the threatening prolaps of intra...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::Present surgical techniques to distal obstruction of the nasolacrimal duct system are the external dacryocystorhinostomy (DCR) and alternatively the endonasal laser-assisted DCR and the transcanalicular laser-assisted DCR. Combining the own experiences and the overview of bibliography the different surgical techniques...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 社论,评审
doi:10.1055/s-2008-1034661
更新日期:1999-07-01 00:00:00
abstract::A Turkish baby was treated several times for bilateral "recurrent dendritic keratitis" before a diagnosis of Richner-Hanhart syndrome could be made (recessively inherited keratosis palmaris et plantaris with pathognomonic corneal dystrophy). No effective conservative treatment has been reported in the literature for t...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Light phenomena evoked by a Kratz elliptical posterior chamber lens, a Mark Choyce IX anterior chamber lens, and a four-loop Binkhorst anterior chamber lens were investigated in a model with pupils of various sizes. Besides monocular diplopia, the edge of the lens produces scattered light phenomena which vary accordin...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050471
更新日期:1987-07-01 00:00:00
abstract::The suitability of ultrasonography, computer tomography and Octopus perimetry is illustrated with reference to an investigation carried out in 60 patients. First, the characteristic symptoms are described, depending on the localization of the lesion in the visual pathway. Then the advantages and disadvantages of the v...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1055172
更新日期:1982-08-01 00:00:00
abstract::Lens implants can focus dangerous quantities of visible short-wavelength light on the retina. The present paper described how actinic damage to the macula can be avoided by using an absorption filter in the ophthalmoscope which absorbs light of shorter wavelengths than 420 nm. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050931
更新日期:1985-04-01 00:00:00
abstract::The effect of filtering operations on 133 eyes was investigated by fluorescence photography after intracameral injection of fluorescein. The following drainage mechanisms could be found: 1. the transconjunctival route, 2. the diffuse resorption through degenerated veins, 3. bulkflow through lymphatic vessels, 4. bulkf...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-01-01 00:00:00
abstract::Knowledge of normal differentiations is indispensable for interpreting developmental disturbances in animal experiments. Accordingly, the investigations described in the present paper were aimed at explaining the process of myelinization of the optic nerve in the domestic mouse breed Agnes Bluhm Jena-Halle. First sign...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054917
更新日期:1983-10-01 00:00:00
abstract::Patients suffering from neovascular glaucoma who had been treated at the First Vienna University Eye Clinic in the years 1966-1979 were analyzed recently in a retrospective study. The present paper concentrates on 144 cases of hemorrhagic secondary glaucoma after central venous thrombosis. It considers only those pati...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1054882
更新日期:1983-08-01 00:00:00
abstract::The introduction of cataract extraction by Jacques Daviel, in 1752/53, appears to us as a revolutionary step in eye surgery. It should be realized, however, that this achievement was not only the result of intuition and bold decision in critical situations, but also of careful evaluation, over seven years, of extracti...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 传,历史文章,杂志文章
doi:10.1055/s-2008-1050913
更新日期:1985-03-01 00:00:00