BCR-ABL rearrangement in a child with acute myelogenous leukaemia without a Philadelphia chromosome.

abstract：:The prognosis of acute lymphoblastic leukaemia (ALL) in adults is poor compared with children in terms of complete remission (CR) and leukaemia-free survival. In children in vitro resistance of leukaemic cells to various cytotoxic agents is an independent poor prognostic marker, but the relevance of in vitro drug resi...

journal_title：British journal of haematology

authors： Maung ZT,Reid MM,Matheson E,Taylor PR,Proctor SJ,Hall AG

更新日期：1995-09-01 00:00:00

abstract：:To determine the effects of L-arginine (L-Arg) supplementation on nitric oxide metabolite (NOx) production, oral L-Arg was given to normal controls, sickle cell disease (SCD) patients at steady state and SCD patients hospitalized with a vaso-occlusive crisis (VOC). L-Arg (0.1 g/kg) increased NOx formation by 18.8 +/- ...

journal_title：British journal of haematology

authors： Morris CR,Kuypers FA,Larkin S,Sweeters N,Simon J,Vichinsky EP,Styles LA

更新日期：2000-11-01 00:00:00

abstract：:Antibodies (Abs) that block factor VIII (FVIII) activity occur in hemophilia A patients treated with FVIII replacement therapy and severely impair treatment. In this work, we designed and synthesized ten peptides whose sequences are found in putative epitopes at the surface of a1 and C2 domains of the FVIII molecule. ...

journal_title：British journal of haematology

authors： Chaves DG,Velloso-Rodrigues C,Moreau V,Nguyen C,Villard S,Belisário AR,Granier C,Santoro MM

更新日期：2008-05-01 00:00:00

abstract：:Accurate clinical staging is crucial for adequate risk-adapted treatment in Hodgkin lymphoma (HL) to prevent patients from under- or over-treatment. Within the latest German Hodgkin Study Group trial generation, diagnostic findings such as histopathology, computerized tomography imaging and clinical risk factors were ...

journal_title：British journal of haematology

authors： Bröckelmann PJ,Goergen H,Fuchs M,Kriz J,Semrau R,Baues C,Kobe C,Behringer K,Eichenauer DA,von Tresckow B,Klimm B,Halbsguth T,Wongso D,Plütschow A,Haverkamp H,Dietlein M,Eich HT,Stein H,Diehl V,Borchmann P,Engert A

更新日期：2015-11-01 00:00:00

abstract：:Minimal (i.e. submicroscopic) residual disease (MRD) predicts outcome in childhood acute lymphoblastic leukaemia (ALL). To be used clinically, MRD assays must be reliable and accurate. Two well-established techniques, flow cytometry (FC) and polymerase chain reaction (PCR), can detect leukaemic cells with a sensitivit...

journal_title：British journal of haematology

authors： Kerst G,Kreyenberg H,Roth C,Well C,Dietz K,Coustan-Smith E,Campana D,Koscielniak E,Niemeyer C,Schlegel PG,Müller I,Niethammer D,Bader P

更新日期：2005-03-01 00:00:00

abstract：:To evaluate the clinical significance of CD21S expression of diffuse large B-cell lymphoma (DLBCL) tumour cells, we compared their clinical features, immunophenotype, response to therapy and outcome in relation to CD21S expression. Between 1987 and 1999, frozen sections from 240 DLBCL cases were examined for CD21S exp...

journal_title：British journal of haematology

authors： Ogawa S,Yamaguchi M,Oka K,Taniguchi M,Ito M,Nishii K,Nakase K,Ohno T,Kita K,Kobayashi T,Shiku H

更新日期：2004-04-01 00:00:00

abstract：:Bruton's tyrosine kinase (BTK) was previously demonstrated to be a mediator of oxidative stress-induced apoptosis in irradiated neoplastic B-cells and B-cell precursors. Defective BTK expression in leukaemic B-cell precursors from infants with t(4;11) acute lymphoblastic leukaemia has been associated with radiation re...

journal_title：British journal of haematology

authors： Uckun F,Ozer Z,Vassilev A

更新日期：2007-02-01 00:00:00

abstract：:A new alpha thalassemia defect has been detected in the South African population. Restriction mapping of the alpha globin gene cluster in affected individuals has established that the defect is associated with the removal of 22.8-23.7 kb of DNA, including the psi zeta 1, psi alpha 1, psi alpha 2, alpha 2 and alpha 1 g...

journal_title：British journal of haematology

authors： Vandenplas S,Higgs DR,Nicholls RD,Bester AJ,Mathew CG

更新日期：1987-08-01 00:00:00

abstract：:Multiple myeloma (MM) is currently incurable, and novel therapies are needed. In this study, we examined a novel recombinant humanized monoclonal antibody against CD40 (rhuCD40 mAb) and demonstrate for the first time that rhuCD40 mAb induces antibody-dependent cell-mediated cytotoxicity (ADCC) against CD40-positive MM...

journal_title：British journal of haematology

authors： Hayashi T,Treon SP,Hideshima T,Tai YT,Akiyama M,Richardson P,Chauhan D,Grewal IS,Anderson KC

更新日期：2003-05-01 00:00:00

abstract：:We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resul...

journal_title：British journal of haematology

authors： Specchia G,Albano F,Anelli L,Storlazzi CT,Cimino G,Liso A,Zagaria A,Liso V,Rocchi M

更新日期：2002-11-01 00:00:00

abstract：:The proteasome inhibitor, bortezomib, potentially increases cell sensitivity to chemotherapy. This study was performed to determine the overall response rate (ORR), overall survival (OS), progression-free survival (PFS) and toxicity of CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) compared to CHOP...

journal_title：British journal of haematology

authors： Furtado M,Johnson R,Kruger A,Turner D,Rule S

更新日期：2015-01-01 00:00:00

abstract：:Liposome-entrapped desferrioxamine was administered to iron-over-loaded 59Fe lavelled mice. When given orally or intraperitoneally entrapment did not enhance the effect of the chelator, but given intravenously liposomal desferrioxamine doubled the 59Fe excretion for a given dose of the drug, and excretion after a sing...

journal_title：British journal of haematology

authors： Young SP,Baker E,Huehns ER

更新日期：1979-03-01 00:00:00

abstract：:Sézary syndrome and Mycosis fungoides are the most common forms of cutaneous T-cell lymphomas. To assess the response to different therapies especially in Sézary syndrome, it is helpful to monitor the percentage of circulating tumour cells in the blood. The use of T-cell receptor (TCR)-Vbeta specific monoclonal antibo...

journal_title：British journal of haematology

authors： Schwab C,Willers J,Niederer E,Ludwig E,Kündig T,Grob P,Burg G,Dummer R

更新日期：2002-09-01 00:00:00

abstract：:Two patients are described who had evidence of both multiple myeloma and chronic neutrophilic leukaemia at or near the time of presentation. Descriptions of five similar patients were found in the literature supporting an association between the two disorders. This association is further evidence of a link between mye...

journal_title：British journal of haematology

authors： Lewis MJ,Oelbaum MH,Coleman M,Allen S

更新日期：1986-05-01 00:00:00

abstract：:MLL rearrangements were analysed in the blood of a patient receiving chemotherapy for diffuse large B-cell lymphoma using inverse polymerase chain reaction targeting exon 12, parallel sequencing and a custom algorithm design. Of thirteen MLL rearrangements detected, five were capable of generating MLL fusion genes, in...

journal_title：British journal of haematology

authors： Shih SJ,Fass J,Buffalo V,Lin D,Singh SP,Diaz MO,Vaughan AT

更新日期：2012-10-01 00:00:00

abstract：:The myelodysplastic syndromes (MDS) have a significant frequency of evolution into acute myeloid leukaemia (AML). Approximately 30% of MDS patients show activating mutations of the N-RAS proto-oncogene, and these patients are at increased risk of leukaemic evolution. Long-term survivors of aplastic anaemia (AA) and pa...

journal_title：British journal of haematology

authors： White JR,Josten KM,Chopra R,Tooze J,Saso R,Gordon-Smith EC,Rutherford TR

更新日期：1995-12-01 00:00:00

abstract：:The purpose of the present work were to identify the initial characteristics associated with long-term survival in chronic granulocytic leukaemia (CGL) and to analyse the accuracy of prognostic models in identifying long-term survivors. 813 Philadelphia (Ph) chromosome-positive, nonblastic CGL patients from six Americ...

journal_title：British journal of haematology

authors： Cervantes F,Robertson JE,Rozman C,Baccarani M,Tura S,Gómez GA,Braun TJ,Clarkson BD,Pereira A

更新日期：1994-06-01 00:00:00

abstract：:The uptake of iron by bone marrow erythroblasts and its intracellular distribution have been studied in 23 patients with primary sideroblastic anaemia (SA), five patients with secondary SA and one patient with only non-ringed sideroblasts. EM of erythroblasts from 18 cases showed both mitochondrial iron deposits and c...

journal_title：British journal of haematology

authors： May A,de Souza P,Barnes K,Kaaba S,Jacobs A

更新日期：1982-12-01 00:00:00

abstract：:In a 2.5-month-old infant with beta-thalassaemia major, DNA analysis of the gamma-beta region revealed homozygosity for two large deletions removing the entire psi beta and beta regions including their 5' promoter regions but leaving the delta gene intact. The downstream deletion was predicted to be 7.6 kb in length e...

journal_title：British journal of haematology

authors： Oner C,Oner R,Gürgey A,Altay C

更新日期：1995-02-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifunctional haematopoietin which can promote production of several blood cell lineages, though the predominant target cells are neutrophils, monocytes, and their precursors. Occasional undesirable clinical effects include eosinophilia, an increase in b...

journal_title：British journal of haematology

authors： Kurzrock R,Talpaz M,Gomez JA,Estey EH,O'Brien S,Hirsch-Ginsberg C,Koller C,Freireich EJ,Gutterman JU

更新日期：1991-07-01 00:00:00

abstract：:Myelofibrosis is characterized by splenomegaly and debilitating constitutional symptoms that negatively impact patients' quality of life. ROBUST, a UK, open-label, phase II study, evaluated the safety and efficacy of ruxolitinib in patients with myelofibrosis (N = 48), including intermediate-1 risk patients. The prima...

journal_title：British journal of haematology

authors： Mead AJ,Milojkovic D,Knapper S,Garg M,Chacko J,Farquharson M,Yin J,Ali S,Clark RE,Andrews C,Dawson MK,Harrison C

更新日期：2015-07-01 00:00:00

abstract：:High-dose chemotherapy (HDT) with autologous stem cell transplantation is the standard of care for relapsed/refractory (RR) Hodgkin lymphoma (HL). Given that HDT may cure a sizeable proportion of patients refractory to first salvage, development of newer conditioning regimens remains a priority. We present the results...

journal_title：British journal of haematology

authors： Musso M,Messina G,Di Renzo N,Di Carlo P,Vitolo U,Scalone R,Marcacci G,Scalzulli PR,Moscato T,Matera R,Crescimanno A,Santarone S,Orciuolo E,Merenda A,Pavone V,Pastore D,Donnarumma D,Carella AM,Ciochetto C,Cascavilla

更新日期：2016-01-01 00:00:00

abstract：:Anti-thymocyte globulins (ATG) are currently used to prevent graft-versus-host disease in haematopoietic stem cell transplants from alternative donors and to treat and prevent acute organ rejection after transplantation. Many recent studies have demonstrated that ATG can also be beneficial in patients with myeloma, ly...

journal_title：British journal of haematology

authors： Polito L,Bortolotti M,Farini V,Pedrazzi M,Tazzari PL,Bolognesi A

更新日期：2009-12-01 00:00:00

abstract：:Chemokines are a family of over 40 small (8 kDa) related proteins with the function of moving cells along a chemotactic gradient, either to organise cells within an organ or to facilitate the movement of leucocytes around the body. Mouse models have implicated the importance of the chemokine CXCL12 in haematopoiesis a...

journal_title：British journal of haematology

authors： Laurence AD

更新日期：2006-02-01 00:00:00

abstract：:We report a case of acquired sideroblastic anaemia precipitated by progesterone. On two separate occasions, over 15 years apart, the patient developed sideroblastic anaemia with iron overload shortly after the administration of progesterone. No other cause for sideroblastic anaemia was found, and treatment with folic ...

journal_title：British journal of haematology

authors： Brodsky RA,Hasegawa S,Fibach E,Dunbar CE,Young NS,Rodgers GP

更新日期：1994-08-01 00:00:00

abstract：:In a uniform series of 170 untreated myeloma patients (MM) we investigated the distribution of T cell subsets in peripheral blood (PB) and their relationship with the most relevant disease characteristics, including survival. CD4 cells were significantly decreased both in percentage and absolute numbers (P less than 0...

journal_title：British journal of haematology

authors： San Miguel JF,González M,Gascón A,Moro MJ,Hernández JM,Ortega F,Jiménez R,Guerras L,Romero M,Casanova F

更新日期：1992-03-01 00:00:00

abstract：:The inoculation of L1210 or L5178Y leukaemia cells decreased the platelet count of the recipient mouse before extensive infiltration of marrow was expected by either tumour line. The decrease was more pronounced after intravenous inoculation of L1210 leukaemia than after intraperitoneal inoculation. Inoculation of L51...

journal_title：British journal of haematology

authors： Hacker M,Roberts D,Jackson C

更新日期：1977-03-01 00:00:00

abstract：:Stage I/IIA follicular lymphoma (FL) is considered a localised disease that can be adequately treated with radiotherapy alone. Bone marrow (BM) and peripheral blood (PB) involvement in FL was investigated by polymerase chain reaction (PCR) in a series of 24 consecutive patients with histologically revised diagnosis an...

journal_title：British journal of haematology

authors： Pulsoni A,Starza ID,Frattarelli N,Ghia E,Carlotti E,Cavalieri E,Matturro A,Tempera S,Rambaldi A,Foà R

更新日期：2007-05-01 00:00:00

abstract：:Cross-species Northern blot hybridization and radioimmunoassay have provided evidence for the expression of an erythropoietin (EPO)-like gene in the rainbow trout. The principal site of EPO-like mRNA and antigen expression in the adult trout appears to be the kidney which also acts as the major erythropoietic organ. T...

journal_title：British journal of haematology

authors： Shiels A,Wickramasinghe SN

更新日期：1995-05-01 00:00:00

abstract：:Enlarged lymph nodes may be a marker of occult cancer, but accurate data on cancer risk are limited. We used population-based Danish medical registries to assess cancer risk in a cohort of patients with a first-time inpatient or outpatient hospital contact for enlarged lymph nodes during 1994-2008. Observed cancer inc...

journal_title：British journal of haematology

authors： Frederiksen H,Svaerke C,Thomsen RW,Farkas DK,Pedersen L,Weiss NS,Sørensen HT

更新日期：2013-03-01 00:00:00