Improvements in the prevention of postoperative venous thromboembolism in hip fracture patients.

Abstract:

:Hip fracture surgery carries a high risk of venous thromboembolism and, until recently, was poorly investigated. The efficacy and safety of fondaparinux, a new synthetic antithrombotic, were investigated in two large, thromboprophylaxis studies. Results of the Penthifra study, which was a randomized, double-blind phase III trial, showed that 1 week of fondaparinux, compared with enoxaparin, significantly reduced venous thromboembolic events from 19.1% to 8.3% (relative risk reduction: 56.4%; P<.001) without increasing bleeding risk. Penthifra Plus results showed that extending fondaparinux prophylaxis from 1 to 4 weeks was well tolerated and, compared to placebo, significantly reduced delayed venous thromboembolism events from 35% to 1.4% (relative risk reduction: 95.9%; P<.001). Based on these findings, 4-week fondaparinux treatment may become the standard thromboprophylaxis after hip fracture surgery.

journal_name

Orthopedics

journal_title

Orthopedics

authors

Eriksson BI

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

s851-8

issue

8 Suppl

eissn

0147-7447

issn

1938-2367

journal_volume

26

pub_type

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