Relationship of arachidonic acid concentration to cyclooxygenase-dependent human platelet aggregation.

abstract：:Cyclosporine (CsA) dosing is based on CsA plasma or blood concentrations measured 12 to 24 hours after drug administration (trough levels). This study evaluated the relationship between the timing of CsA concentrations and subsequent pharmacokinetic parameters to predict an optimal sampling period. Plasma samples were...

journal_title：Journal of clinical pharmacology

authors： Regazzi MB,Rondanelli R,Gastaldi L,Martinelli L,Viganò M

更新日期：1992-11-01 00:00:00

abstract：:A method of estimating the elimination half-life of a drug at any selected serum concentration when the Km and Vmax of that drug are known is described. The method was validated in six patients by determining their Km and Vmax values for phenytoin, using data obtained at two serum concentrations and then using the Km ...

journal_title：Journal of clinical pharmacology

authors： Browne TR,Greenblatt DJ,Evans JE,Szabo GK,Evans BA,Schumacher GE

更新日期：1987-04-01 00:00:00

abstract：:Serial pharmacokinetic (PK) sampling in 1159 patients from TRITON-TIMI 38 was undertaken. A multilinear regression model was used to quantitatively predict prasugrel's active metabolite (Pras-AM) concentrations from its 2 downstream inactive metabolites. Population-based methods were then applied to Pras-AM concentrat...

journal_title：Journal of clinical pharmacology

authors： Wrishko RE,Ernest CS 2nd,Small DS,Li YG,Weerakkody GJ,Riesmeyer JR,Macias WL,Rohatagi S,Salazar DE,Antman EM,Wiviott SD,Braunwald E,Ni L

更新日期：2009-08-01 00:00:00

abstract：:Angiotensin converting enzyme (ACE) inhibitors are increasingly important in antihypertensive therapy because of their efficacy, tolerability, and specific benefits in subsets of patients. They are pharmacologically diverse. Whereas most benefits have been proven with older agents (captopril, enalopril), newer agents,...

journal_title：Journal of clinical pharmacology

authors： Burris JF

更新日期：1995-04-01 00:00:00

abstract：:Hypertensive emergency is a condition in which there is elevation of both systolic and diastolic blood pressure with the presence of acute target organ disease. Hypertensive urgency is a condition where the blood pressure is elevated (diastolic > 120 mmHg) with the absence of acute target organ disease. Hypertensive e...

journal_title：Journal of clinical pharmacology

authors： Abdelwahab W,Frishman W,Landau A

更新日期：1995-08-01 00:00:00

abstract：:This article describes the population pharmacokinetics (PK) of dalteparin in pediatric patients with venous thromboembolism (VTE). A prospective multicenter open-label study was conducted in children who required anticoagulation for the treatment of VTE. The study population included children with and without cancer. ...

journal_title：Journal of clinical pharmacology

authors： Damle B,Jen F,Sherman N,Jani D,Sweeney K

更新日期：2021-02-01 00:00:00

abstract：:As part of a clinical trial investigating the level of nicotine replacement with different doses of transdermal therapy for smoking cessation, urine excretion rates of nicotine and cotinine were measured in 70 subjects while they were actively smoking (baseline) and for 6 consecutive inpatient days while they were rec...

journal_title：Journal of clinical pharmacology

authors： Lawson GM,Hurt RD,Dale LC,Offord KP,Croghan IT,Schroeder DR,Jiang NS

更新日期：1998-06-01 00:00:00

abstract：:The objective of this study was to establish effects of inhaled loxapine on the QTc interval in this randomized, placebo-controlled, double-blind crossover study. Forty-eight healthy volunteers received a single inhaled placebo or 10 mg loxapine. Plasma concentrations of loxapine increased with a median Tmax of 1 minu...

journal_title：Journal of clinical pharmacology

authors： Spyker DA,Voloshko P,Heyman ER,Cassella JV

更新日期：2014-06-01 00:00:00

abstract：:Traditionally, Phase I tolerance trials have been done with normal volunteers to establish single- and multiple-dose tolerance. We feel that the justification for doing multiple-dose tolerance studies in normals is open to question and that, in fact, more pertinent data can be generated by using the appropriate patien...

journal_title：Journal of clinical pharmacology

authors： Weissman L

更新日期：1981-10-01 00:00:00

abstract：:The antihypertensive effect and safety of hydrochlorothiazide administration as a single drug and together with medroxalol were determined in 20 patients with primary hypertension. Following two biweekly intervals on placebo and hydrochlorothiazide, medroxalol was started at 100 mg three times a day and titrated again...

journal_title：Journal of clinical pharmacology

authors： Vlachakis ND,Valasquez M,Alexander N,Maronde RF

更新日期：1983-10-01 00:00:00

abstract：:The objective of this randomized clinical trial was to compare steady-state gestational RBC and plasma folate concentrations in pregnant women supplementing daily with 1.1 mg (regular dose) vs. 5 mg (high dose) folic acid. Thirty-seven pregnant women, who were not previously taking folic acid, were enrolled in this op...

journal_title：Journal of clinical pharmacology

authors： Shere M,Nguyen P,Tam C,Stern S,Kapur B,O'Connor DL,Koren G

更新日期：2015-02-01 00:00:00

abstract：:The pharmacokinetics, pharmacodynamics, and safety of the marketed formulation of microencapsulated octreotide acetate were evaluated in an open-label study in 22 healthy cholecystectomized subjects. Each subject received a single 30 mg dose of microencapsulated octreotide acetate intramuscularly (i.m.). Concentration...

journal_title：Journal of clinical pharmacology

authors： Chen T,Miller TF,Prasad P,Lee J,Krauss J,Miscik K,Kalafsky G,McLeod JF

更新日期：2000-05-01 00:00:00

abstract：:A clinical study was performed on 41 asthmatic patients. After complete physical and spirometric examinations, they received capsules containing 200 mg anhydrous theophylline per capsule t.i.d. for three weeks. All other antiasthmatic medications were omitted during this study. The results showed that these capsules (...

journal_title：Journal of clinical pharmacology

authors： Miller J,Salem H

更新日期：1976-07-01 00:00:00

abstract：:Of 17,068 hospitalized medical patients monitored in a drug surveillance program, 616 (3.6 per cent) received pentazocine hydrochloride orally and 816 (4.8 per cent) received pentazocine lactate parenterally during one or more admissions. Unsatisfactory analgesic efficacy as judged by each patient's physician was near...

journal_title：Journal of clinical pharmacology

authors： Miller RR

更新日期：1975-02-01 00:00:00

abstract：:Guanfacine, an alpha 2 adrenoceptor agonist, was compared with prazosin hydrochloride for the treatment of patients with mild to moderate essential hypertension in an 8-week, double-blind, randomized, parallel evaluation to determine efficacy and safety. The study consisted of a 2-week screening/weaning period (phase ...

journal_title：Journal of clinical pharmacology

authors： Lewin A,Alderman MH,Mathur P

更新日期：1990-12-01 00:00:00

abstract：:Selection of the first dose for neonates in clinical trials is very challenging. The objective of this analysis was to assess if a population pharmacokinetic (PK) model developed with data from infants to adults is predictive of neonatal clearance and to evaluate what age range of prior PK data is needed for informati...

journal_title：Journal of clinical pharmacology

authors： Wang J,Edginton AN,Avant D,Burckart GJ

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this analysis was to develop a population pharmacokinetic model for CS-917, an oral hypoglycemic prodrug, and its 3 metabolites. The population pharmacokinetic model was used to predict exposure of the active moiety R-125338 and thus to identify potential CS-917 dosage reduction criteria. The dataset in...

journal_title：Journal of clinical pharmacology

authors： Kastrissios H,Walker JR,Carrothers TJ,Kshirsagar S,Khariton T,Habtemariam B,Mager DE,Rohatagi S

更新日期：2012-03-01 00:00:00

abstract：:Procaterol, a new beta-adrenergic agonist, was tested in two different doses in patients with reversible airway obstruction. Single oral doses of 0.05 or 0.1 mg produce an increase in measured expiratory flow rates, and the peak and duration of action are both dose related. Side effects reported during this one-day st...

journal_title：Journal of clinical pharmacology

authors： Zanetti CL,Rotman HH,Dresner AJ

更新日期：1982-05-01 00:00:00

abstract：:The availability of poisoning information from the pharmaceutical industry was evaluated. Manufacturers of the top 50 drugs were surveyed. Information that was received was classified by established criteria for evaluation. Compendia on poisoning information was evaluated based on 11 components ranging from toxicity i...

journal_title：Journal of clinical pharmacology

authors： Bolger PB,Shimomura SK,Cupit GC,Davis LJ,McCart GM

更新日期：1979-02-01 00:00:00

abstract：:Interethnic variability in pharmacokinetics can cause unexpected outcomes such as therapeutic failure, adverse effects, and toxicity in subjects of different ethnic origin undergoing medical treatment. It is important to realize that both genetic and environmental factors can lead to these differences among ethnic gro...

journal_title：Journal of clinical pharmacology

authors： Kim K,Johnson JA,Derendorf H

更新日期：2004-10-01 00:00:00

abstract：:A series of clinical pharmacology studies was performed to screen for possible pharmacokinetic/dynamic contributions to drug interactions reported in rheumatoid arthritis patients receiving cyclosporine and nonsteroidal antiinflammatory drugs (NSAIDs). No clinically relevant pharmacokinetic changes in any of the drugs...

journal_title：Journal of clinical pharmacology

authors： Kovarik JM,Mueller EA,Gerbeau C,Tarral A,Francheteau P,Guerret M

更新日期：1997-04-01 00:00:00

abstract：:This randomized crossover study in healthy participants assessed pharmacokinetic interactions between telavancin, aztreonam, and piperacillin/tazobactam. Part 1: 11 participants received telavancin 10 mg/kg, aztreonam 2 g, or a combination of telavancin 10 mg/kg+aztreonam 2 g intravenously on 3 separate days. Part 2: ...

journal_title：Journal of clinical pharmacology

authors： Wong SL,Sörgel F,Kinzig M,Goldberg MR,Kitt MM,Barriere SL

更新日期：2009-07-01 00:00:00

abstract：:Atrial fibrillation is very common in the United States. After a search of Medline, EMBASE, and CINAHL, 4 trials evaluating inhibitors of the renin-angiotensin system were identified for prevention of new-onset atrial fibrillation, facilitation of electrical cardioversion of atrial fibrillation, and prevention of atri...

journal_title：Journal of clinical pharmacology

authors： Kalus JS,Coleman CI,White CM

更新日期：2006-01-01 00:00:00

abstract：:Patients with heart failure (HF) are at increased risk for drug-induced torsades de pointes (TdP) due to unknown mechanisms. Our objective was to determine if sensitivity to drug-induced QT interval lengthening is enhanced in patients with HF. In this multicenter, prospective study, 15 patients with atrial fibrillatio...

journal_title：Journal of clinical pharmacology

authors： Tisdale JE,Overholser BR,Wroblewski HA,Sowinski KM,Amankwa K,Borzak S,Kingery JR,Coram R,Zipes DP,Flockhart DA,Kovacs RJ

更新日期：2012-09-01 00:00:00

abstract：:Twenty young (45 years or younger) and 20 older (55 years or older) adult patients with mild hypertension were enrolled in this study to compare the hemodynamic effects of labetalol versus placebo in two age groups. Ten patients in each group were randomly assigned to receive either a single oral dose of labetalol (20...

journal_title：Journal of clinical pharmacology

authors： Buell JC,Eliot RS,Plachetka JR,Little MR

更新日期：1988-04-01 00:00:00

abstract：:Relationships between tocilizumab exposure and response were evaluated using data from 4 phase III studies. Increased tocilizumab exposure was associated with improvements in Disease Activity Score using 28 joints (DAS28) and American College of Rheumatology (ACR) criteria and with a decrease in inflammation markers. ...

journal_title：Journal of clinical pharmacology

authors： Levi M,Grange S,Frey N

更新日期：2013-02-01 00:00:00

abstract：:The safety and pharmacokinetics of single and multiple administrations of cefpirome (HR810), a new cephalosporin antibiotic agent with a broad antibacterial spectrum, were studied in healthy male volunteers. The single administration protocols included a 3-minute intravenous injection of 0.5 g or 1 g, and a 1-hour int...

journal_title：Journal of clinical pharmacology

authors： Nakayama I,Akieda Y,Yamaji E,Nitta Y,Ohishi M,Katagiri K,Imamura N,Takase K

更新日期：1992-03-01 00:00:00

abstract：:The safety and efficacy of step-one therapy with enalapril, a new angiotensin-converting enzyme inhibitor, and metoprolol were compared in a double-blind, multicenter study involving 150 patients who had mild to moderate essential hypertension. After a four-week period of placebo run-in, therapy was initiated with twi...

journal_title：Journal of clinical pharmacology

authors： Nugent LW,Miola SR,Walker JF

更新日期：1987-07-01 00:00:00

abstract：:A study was conducted evaluating the efficacy of loxapine succinate in newly admitted schizophrenic patients through a four-week double-blind comparison with trifluoperazine. Twenty-four patients received between 40 and 80 mg loxapine succinate daily and 19 patients received between 20 and 50 mg trifluoperazine daily....

journal_title：Journal of clinical pharmacology

authors： Simpson GM,Cuculic Z

更新日期：1976-01-01 00:00:00

abstract：:In this study, the authors assessed the bioequivalence of two fluoxetine tablet formulations in 24 healthy volunteers of both sexes who received a single 20 mg dose of each fluoxetine formulation, and a new sensitive method for the quantification of fluoxetine and norfluoxetine in human plasma was developed. The study...

journal_title：Journal of clinical pharmacology

authors： Moraes MO,Lerner FE,Corso G,Bezerra FA,Moraes ME,De Nucci G

更新日期：1999-10-01 00:00:00