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Pyrazolopyridine derivative acts as a novel cyclooxygenase inhibitor: antiplatelet effect in aged patients with ischemic stroke.

Abstract：

OBJECTIVE:To examine the antiplatelet effect of a novel pyrazolopyridine derivative (KC-764) in geriatric patients with ischemic stroke. DESIGN:Randomized clinical trial of three graded dose levels. SETTING:A geriatric clinic attached to a nursing home. PATIENTS:Fifteen patients with a history of cerebral infarction with a mean age of 75 +/- 5 years (range, 65-83). Patients were divided into three groups and administered 10, 20, or 40 mg/day KC-764 for 8 weeks. MEASUREMENTS:Platelet aggregation induced by arachidonate, ADP, collagen and platelet-activating factor. Plasma or serum levels of thromboxane B2 and 6-ketoprostaglandin F1 alpha. MAIN RESULTS:Platelet aggregation was inhibited by KC-764 administration and returned to the control level after discontinuation. Although plasma thromboxane B2 levels were markedly decreased, plasma 6-ketoprostaglandin F1 alpha was not affected. However, the dose of 10 mg/day was not sufficient to maintain an effective plasma level of KC-764. There were no side effects or changes in laboratory findings. CONCLUSIONS:We confirmed that KC-764 at a dose of 20 to 40 mg/day is an effective antiplatelet agent and a good candidate for a trial to see if it is feasible for long-term use for the prevention of ischemic stroke in high-risk patients.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Satoh K,Yoshida H,Imaizumi TA,Koyama M,Hiramoto M,Takamatsu S

doi

10.1111/j.1532-5415.1994.tb06863.x

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

639-42

issue

6

eissn

0002-8614

issn

1532-5415

journal_volume

42

pub_type

临床试验,杂志文章,随机对照试验

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