当前位置： SCI文献检索 > AMERICAN JOURNAL OF EPIDEMIOLOGY期刊下所有文献 > Changing patterns of anal cancer incidence in the United States, 1940-1989.

Changing patterns of anal cancer incidence in the United States, 1940-1989.

Abstract：

:Anal cancer has been hypothesized to be associated with a sexually transmitted agent and, more recently, with the epidemic of human immunodeficiency virus (HIV). The authors used a descriptive incidence study to evaluate these hypotheses based on US data from the Surveillance, Epidemiology, and End Results (SEER) program for 1973-1989 and from the Connecticut Tumor Registry for 1940-1988. Since 1960, anal cancer incidence in Connecticut increased 1.9-fold among men and 2.3-fold among women. Based on information from SEER, the incidence was lowest among white men (1973-1989 average: 0.41/100,000) and highest among black women (1973-1989 average: 0.74/100,000). Residents of the metropolitan areas had a twofold risk of anal cancer compared with populations in less densely populated areas. The most dramatic change in incidence was observed for white men in the San Francisco Bay area, among whom the incidence increased from 0.5/100,000 in 1973-1975 to 1.2/100,000 in 1988-1989 (p trend < 0.001). The relative risks (95% confidence intervals) of anal cancer among never married men compared with ever married men in the urban areas rose from 5.8 (0.9-8.7) in 1973-1978 to 6.7 (4.7-9.5) in 1979-1984 and 10.3 (7.5-14.1) in 1985-1989 (p trend = 0.02). No significant difference was observed among women. In conclusion, anal cancer incidence in the United States has increased significantly during the past 30 years and is now higher in women than men, in blacks than whites, and in residents of metropolitan rather than rural areas. Some of this changing pattern clearly relates to the period prior to the acquired immunodeficiency syndrome (AIDS) epidemic and argues that behavioral changes are important in anal cancer development. However, the recent remarkable change in rates among never married men and men living in the San Francisco Bay area suggests that homosexual men are at special and increasing risk. The authors speculate whether part of this recent increase could be attributed to the AIDS epidemic.

journal_name

Am J Epidemiol

journal_title

American journal of epidemiology

authors

Melbye M,Rabkin C,Frisch M,Biggar RJ

doi

10.1093/oxfordjournals.aje.a117073

subject

Has Abstract

pub_date

1994-04-15 00:00:00

pages

772-80

issue

eissn

0002-9262

issn

1476-6256

journal_volume

139

pub_type

杂志文章

在线工具

Changing patterns of anal cancer incidence in the United States, 1940-1989.