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A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers.

Abstract：

:Chronic wounds such as venous stasis ulcers have become a socioeconomic problem. Even with successful initial management, the recurrence rate approaches 70%. With the advent of new wound healing agents, nonoperative attempts to heal these wounds appear indicated. This study reports a prospective randomized evaluator-blinded trial comparing two potential wound healing agents to an inert vehicle placebo. Eighty-six evaluable patients completed the trial. Silver sulfadiazine 1% in a cream proved to statistically reduce the ulcer size compared with a biologically active tripeptide copper complex 0.4% cream formulation or the placebo. There was no difference between the latter two treatments. Silver sulfadiazine has been shown to allow keratinocyte replication and to have antiinflammatory properties. In this trial its antibacterial action was not used since all ulcers had comparable bacterial levels (less than or equal to 10(5)/gm of tissue) before treatment. These results suggest that the silver sulfadiazine cream used in this study may facilitate healing in wounds healing largely by the process of epithelialization.

journal_name

J Vasc Surg

journal_title

Journal of vascular surgery

authors

Bishop JB,Phillips LG,Mustoe TA,VanderZee AJ,Wiersema L,Roach DE,Heggers JP,Hill DP Jr,Taylor EL,Robson MC

doi

10.1067/mva.1992.37086

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

251-7

issue

2

eissn

0741-5214

issn

1097-6809

pii

0741-5214(92)90115-O

journal_volume

16

pub_type

临床试验,杂志文章,随机对照试验

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