Inflammatory changes secondary to postoperative complications of Hirschsprung's disease as a cause of histopathologic changes typical of intestinal neuronal dysplasia.

Abstract:

PURPOSE:The aim of this study was to clarify the pathogenesis of intestinal neuronal dysplasia (IND). METHODS:The bowel habits of 36 postoperative HD patients were assessed retrospectively. Twenty-five had no complaints. Seven had persistent enterocolitis and were the focus of our study. They were divided into group A (n = 2) if they were severe and had associated postoperative surgical complications, and group B (n = 5) if they were mild. The histological changes were assessed. RESULTS:The 7 patients who had persistent enterocolitis postoperatively had no AchE activity in the mucosa, and there was normal distribution of submucosal and myenteric ganglia in the proximal resection margin. Rectal biopsies performed postoperatively for investigation of persistent enterocolitis in group A showed inflammatory changes and typical histopathologic features of IND such as abundant acetylcholinesterase (AchE)-positive nerve fibers in the lamina propria associated with giant submucosal ganglia and hyperganglionosis, and in group B there was increased AchE activity without hyperganglionosis or giant ganglia. CONCLUSIONS:This is the first report of histopathologic changes typical of IND occurring in response to persistent enterocolitis related to postoperative complications of surgery for HD.

journal_name

J Pediatr Surg

authors

Kobayashi H,Yamataka A,Lane GJ,Miyano T

doi

10.1016/j.jpedsurg.2003.10.008

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

152-6; discussion 152-6

issue

2

eissn

0022-3468

issn

1531-5037

pii

S0022346803007978

journal_volume

39

pub_type

杂志文章
  • Adeno-associated virus (AAV)-mediated gene transfer in respiratory epithelium and submucosal gland cells in human fetal tracheal organ culture.

    abstract:BACKGROUND/PURPOSE:Since the discovery of the cystic fibrosis transmembrane regulator (CFTR) gene, cystic fibrosis has been an attractive target for gene therapy. Postnatal gene transfer in the respiratory epithelium has been difficult and particularly inefficient in the submucosal gland cells, the target cells for CFT...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2002.33843

    authors: Lim FY,Martin BG,Sena-Esteves M,Radu A,Crombleholme TM

    更新日期:2002-07-01 00:00:00

  • Indomethacin-associated bowel perforations: a study of possible risk factors.

    abstract:BACKGROUND:The association between indomethacin administration and bowel perforation in premature infants is well known. The goal of this study was to examine possible risk factors for this complication. METHODS:Fifteen cases of indomethacin-associated bowel perforation occurred from 1993 to 1996. All had a birth weig...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90495-5

    authors: Shorter NA,Liu JY,Mooney DP,Harmon BJ

    更新日期:1999-03-01 00:00:00

  • Intestinal cytokine gene expression in infants with acute necrotizing enterocolitis: interleukin-11 mRNA expression inversely correlates with extent of disease.

    abstract:BACKGROUND/PURPOSE:The authors have shown previously that surgical specimens from infants with acute necrotizing enterocolitis (NEC) show upregulation of inducible nitric oxide (NO) synthase (iNOS) and interferon-gamma mRNA. However, the contribution of other inflammatory cytokines such as interleukin-8 (IL-8), IL-11, ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2001.25726

    authors: Nadler EP,Stanford A,Zhang XR,Schall LC,Alber SM,Watkins SC,Ford HR

    更新日期:2001-08-01 00:00:00

  • First clinical application of an automatic VA-ECMO system using artificial hearts as a blood pump.

    abstract::A new extracorporeal membrane oxygenation (ECMO) circuit using air-driven artificial hearts as a blood pump was first applied on a newborn with congenital diaphragmatic hernia. ECMO was continued for 67 hours 36 minutes with no mechanical trouble. Since the artificial hearts changed their output automatically in propo...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90334-h

    authors: Ito T,Seo T,Ishiguro T,Takagi H

    更新日期:1993-06-01 00:00:00

  • Laparoscopic repair of congenital midureteric strictures in infants and children.

    abstract:PURPOSE:Congenital midureteric strictures (CMUS) are an uncommon cause of obstructive uropathy. There are only a few case reports of laparoscopic management of CMUS. We present our experience with laparoscopic repair of CMUS in 7 children. PATIENTS AND METHODS:The records of all children (n=7, 5 infants) undergoing la...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2015.07.013

    authors: Chandrasekharam VV

    更新日期:2015-11-01 00:00:00

  • Cardiac arrest in the ECMO candidate.

    abstract::Extracorporeal membrane oxygenation (ECMO) improves survival in appropriately selected full-term neonates with severe respiratory failure. The clinical course and outcome of infants placed on ECMO after sustaining a cardiac arrest is not known. This study reviews the characteristics and outcome of 10 neonates, identif...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(91)90895-z

    authors: von Allmen D,Ryckman FC

    更新日期:1991-02-01 00:00:00

  • Serial transverse enteroplasty as primary therapy for neonates with proximal jejunal atresia.

    abstract::Small bowel atresia is associated with a large size discrepancy between the proximal and distal segments of bowel that has traditionally been managed by resection of the dilated segment, tapering enteroplasty, or plication. Longitudinal intestinal lengthening is rarely performed at the time of the initial operation. M...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2004.11.005

    authors: Wales PW,Dutta S

    更新日期:2005-03-01 00:00:00

  • Avoiding misdiagnosing neuroblastoma as Wilms tumor.

    abstract:PURPOSE:Although occasionally difficult, distinguishing abdominal neuroblastoma (NBL) from Wilms tumor (WT) at presentation is important, as surgical management differs significantly. We reviewed our 20-year experience (1987-2006) treating patients with NBL, focusing on those with an initial diagnosis of WT, to determi...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2008.02.047

    authors: Dickson PV,Sims TL,Streck CJ,McCarville MB,Santana VM,McGregor LM,Furman WL,Davidoff AM

    更新日期:2008-06-01 00:00:00

  • The embryology of foregut malformations.

    abstract::Developmental disorders in the period of the differentiation of the primitive foregut leads to atresia of the esophagus with tracheoesophageal fistula. Most authors think that this differentiation is caused by lateral foregut folds, which fuse in midline, thus forming the tracheoesophageal septum. In order to gain inf...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(87)80254-3

    authors: Kluth D,Steding G,Seidl W

    更新日期:1987-05-01 00:00:00

  • Initial laparoscopic appendectomy versus initial nonoperative management and interval appendectomy for perforated appendicitis with abscess: a prospective, randomized trial.

    abstract:INTRODUCTION:Perforated appendicitis is a common condition in children, which, in a small number of patients, may be complicated by a well-formed abscess. Initial nonoperative management with percutaneous drainage/aspiration of the abscess followed by intravenous antibiotics usually allows for an uneventful interval ap...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jpedsurg.2009.10.039

    authors: St Peter SD,Aguayo P,Fraser JD,Keckler SJ,Sharp SW,Leys CM,Murphy JP,Snyder CL,Sharp RJ,Andrews WS,Holcomb GW 3rd,Ostlie DJ

    更新日期:2010-01-01 00:00:00

  • Esophagogastric dissociation in the neurologically impaired: an alternative to fundoplication?

    abstract:BACKGROUND/PURPOSE:Gastroesophageal reflux is common in children with severe neurological impairment. Fundoplication may produce symptomatic improvement but has a high failure rate. Esophagogastric dissociation (EGD) is an alternative procedure for treatment of gastroesophageal reflux. The aim of this study is to evalu...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2005.03.004

    authors: Goyal A,Khalil B,Choo K,Mohammed K,Jones M

    更新日期:2005-06-01 00:00:00

  • Regional blood flow response to hypothermia in premature, newborn, and neonatal piglets.

    abstract:BACKGROUND/PURPOSE:Hypothermia (HT) remains a significant stress to the newborn and has been implicated in the pathogenesis of necrotizing enterocolitis (NEC). The authors assessed the effect of transient HT (32 degrees C) on regional organ blood flow in anesthetized piglets at age 7 to 10 days preterm (PREM), 1 to 2 d...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(99)90255-5

    authors: Powell RW,Dyess DL,Collins JN,Roberts WS,Tacchi EJ,Swafford AN Jr,Ferrara JJ,Ardell JL

    更新日期:1999-01-01 00:00:00

  • A case report of severe tracheal obstruction requiring extracorporeal membrane oxygenation.

    abstract::The authors describe the case of a near-fatal airway obstruction requiring extracorporeal membrane oxygenation. The patient presented with severe respiratory distress owing to a bean impacted in the distal trachea. The foreign body could not be removed by bronchoscopy because of instability of the patient. The patient...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2006.06.021

    authors: Ignacio RC Jr,Falcone RA Jr,Brown RL

    更新日期:2006-10-01 00:00:00

  • Partial elective pancreatectomy is curative in focal form of permanent hyperinsulinemic hypoglycaemia in infancy: A report of 45 cases from 1983 to 2000.

    abstract:BACKGROUND/PURPOSE:Permanent hyperinsulinemic hypoglycaemia in infancy (PHHI)I is a severe disease that leads to brain damage. Since 1989, pathologists have identified 2 different forms of the disease: a diffuse form (DiPHHI) and a focal form (FoPHHI). The purpose of this study was to adapt surgical techniques in case ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2002.30241

    authors: Crétolle C,Fékété CN,Jan D,Nassogne MC,Saudubray JM,Brunelle F,Rahier J

    更新日期:2002-02-01 00:00:00

  • First employment characteristics for the 2011 pediatric surgery fellowship graduates.

    abstract:PURPOSE:Information regarding initial employment of graduating pediatric surgery fellows is limited. More complete data could yield benchmarks of initial career environment. METHODS:An anonymous survey was distributed in 2011 to 41 pediatric surgery graduates from all ACGME training programs interrogating details of i...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2012.10.024

    authors: Stolar CJ,Aspelund G

    更新日期:2013-01-01 00:00:00

  • Regional reduction in intestinal neuroendocrine cell populations in enterocolitis complicating Hirschsprung's disease.

    abstract::Enterocolitis (EC) remains the most serious complication of Hirschsprung's disease (HD). The aetiology of EC is uncertain. Ischemic and bacterial causes, and recently rotavirus infection, have been suggested to explain the occurrence of EC. The gut has an abundance of neuroendocrine (NE) cells which modulate gut funct...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/0022-3468(93)90520-u

    authors: Soeda J,O'Briain DS,Puri P

    更新日期:1993-08-01 00:00:00

  • Clinical characteristics and conservative treatment of perineal groove.

    abstract:PURPOSE:Perineal groove is a rare congenital anomaly of the perineum, and only a few papers describing a small number of cases have been reported in the medical literature. This study aimed to evaluate the clinical characteristics and proper management of perineal groove. METHODS:We performed a retrospective review of...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2019.07.017

    authors: Ihn K,Na Y,Ho IG,Oh JT

    更新日期:2020-08-01 00:00:00

  • Repeated mechanical lengthening of intestinal segments in a novel model.

    abstract:PURPOSE:Currently, animal models used for mechanical intestinal lengthening utilize a single lengthening procedure prior to analysis or restoration back into continuity. Here we developed a novel surgical model to examine the feasibility of repeated lengthening of intestinal segments. METHODS:A Roux-en-Y jejunojejunos...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2015.03.020

    authors: Scott A,Sullins VF,Steinberger D,Rouch JD,Wagner JP,Chiang E,Lee SL,Wu BM,Dunn JC

    更新日期:2015-06-01 00:00:00

  • Utility of admission serum lactate in pediatric trauma.

    abstract:BACKGROUND/PURPOSE:Serum lactate measurement has a predictive value in adult trauma. To date, there has been no prospective analysis of the predictive value of admission serum lactate in pediatric trauma. METHODS:Admission serum lactate was prospectively measured over a two year period on all children under age 15 yea...

    journal_title:Journal of pediatric surgery

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.jpedsurg.2014.08.013

    authors: Ramanathan R,Parrish DW,Hartwich JE,Haynes JH

    更新日期:2015-04-01 00:00:00

  • Macrophage phenotype during cholestatic injury and repair: the persistent inflammatory response.

    abstract:BACKGROUND/PURPOSE:Biliary decompression for congenital or acquired obstruction (eg, biliary atresia) does not uniformly lead to liver repair, restore function, or prevent cholangitis. The authors hypothesize that failed repair is caused by altered macrophage (Mo) phenotypes central to an ongoing inflammatory and fibro...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2001.20059

    authors: Roggin KK,Kim JC,Kurkchubasche AG,Papa EF,Vezeridis AM,Tracy TF

    更新日期:2001-01-01 00:00:00

  • Successful endoscopic unroofing for a pediatric choledochocele.

    abstract::A choledochocele (type 3 choledochal cyst) is rarely observed in children. A 6-year-old boy experienced abdominal pain approximately 6 times in the previous 5 months. Magnetic resonance cholangiopancreatography findings revealed a small cyst in the distal common bile duct. An endoscopic examination was performed, and ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2009.03.042

    authors: Saeki I,Takahashi Y,Matsuura T,Takahata S,Tanaka M,Taguchi T

    更新日期:2009-08-01 00:00:00

  • Sentinel lymph node biopsy in children and adolescents with malignant melanoma.

    abstract:BACKGROUND/PURPOSE:Sentinel lymph node biopsy (SLNB) provides valuable staging information for adult patients presenting with clinically localized cutaneous melanoma. There are little data pertaining to the use of SLNB in the pediatric melanoma population. The objective of this study is to investigate the use of SLNB i...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(03)00193-3

    authors: Toro J,Ranieri JM,Havlik RJ,Coleman JJ 3rd,Wagner JD

    更新日期:2003-07-01 00:00:00

  • Gastroschisis bowel in an intact exomphalos: implications for etiology and possible prevention.

    abstract::The etiology of changes in the bowel in gastroschisis is unknown. A case of exomphalos is described, in which the bowel had a gastroschisis-like appearance. The possibility of a vascular mechanism as the cause is discussed. ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(96)90735-6

    authors: Steinbrecher HA,Hanna M,Burge DM

    更新日期:1996-03-01 00:00:00

  • Life-threatening complications and mortality of minimally invasive pectus surgery.

    abstract::The prevalence and type of life-threatening complications related to the minimally invasive repair of pectus excavatum (MIRPE) and bar removal are unknown and underreported. The purpose of this communication is to make surgeons aware of the risk of these life threatening complications as well as the modifications whic...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpedsurg.2017.07.020

    authors: Hebra A,Kelly RE,Ferro MM,Yüksel M,Campos JRM,Nuss D

    更新日期:2018-04-01 00:00:00

  • Total colectomy with ileo-endomuscular pull-through in the treatment of ulcerative colitis in children.

    abstract::Since ulcerative colitis is primarily a mucosal disease, total colectomy with rectal mucosectomy and ileo-endomuscular pull-through (Soave) offers many theoretical advantages. The diseased colon is removed, the anal sphincteric mechanism is preserved, and permanent ileostomy is avoided, bladder and sexual function are...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/s0022-3468(81)80346-6

    authors: Zwiren GT,Andrews HG,Caplan DB

    更新日期:1981-04-01 00:00:00

  • Postnatal outcome in gastroschisis: effect of birth weight and gestational age.

    abstract:INTRODUCTION:Early elective delivery of antenatally diagnosed gastroschisis has been proposed as a strategy to minimize postnatal morbidity. This hypothesis was tested by analyzing outcome in relationship to gestational age and birth weight at delivery. METHODS:Single-center retrospective review of infants born with g...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2006.12.034

    authors: Charlesworth P,Njere I,Allotey J,Dimitrou G,Ade-Ajayi N,Devane S,Davenport M

    更新日期:2007-05-01 00:00:00

  • Primary squamous cell carcinoma arising at a gastrostomy tube site.

    abstract::Gastrostomy tubes are commonly used in children with feeding impairment. Postoperative complications such as the formation of granulation tissue are common and represent a type of chronic nonhealing wound. We present a case of a 24-year-old man with no history of malignancy who developed a primary cutaneous squamous c...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2011.01.018

    authors: Oh PS,Gill KZ,Lynch LJ,Cowles RA

    更新日期:2011-04-01 00:00:00

  • Acute abdominal symptoms and signs in children and young adults with spina bifida: ten years' experience.

    abstract:BACKGROUND/PURPOSE:Diagnosis and management of the acute abdomen in patients with spina bifida (SB) can be problematic. There are at least 4 clinical factors that can predispose to the development of acute abdominal symptoms and signs, and patients with a thoracic level lesion can have a partially insensate abdomen. Th...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1053/jpsu.2001.26375

    authors: Worley G,Wiener JS,George TM,Fuchs HE,Mackey JF,Fitch RD,Oldham KT

    更新日期:2001-09-01 00:00:00

  • Amniotic fluid ferritin as a marker of intestinal damage in gastroschisis: a time course experimental study.

    abstract:BACKGROUND/PURPOSE:Intestinal damage (ID) is closely related to morbidity and mortality in gastroschisis. This study was performed to determine the intraamniotic substances that may correlate ID and also to verify their time course levels that would be useful for determining when ID starts in gastroschisis. METHODS:In...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章

    doi:10.1016/j.jpedsurg.2007.05.027

    authors: Cağlar M,Hakgüder G,Ateş O,Olguner M,Coker C,Ozer E,Akgür FM

    更新日期:2007-10-01 00:00:00

  • Successful management of concomitant omphalocele, accessory hepatic lobe, and biliary atresia in a 44-day-old boy.

    abstract::We report the second case in literature of a boy with the association of large omphalocele, accessory hepatic lobe, and biliary atresia, and the first successful treatment. The patient was submitted to a surgical treatment at 44 days of life, including Kasai procedure, correction of the remnant abdominal wall defect, ...

    journal_title:Journal of pediatric surgery

    pub_type: 杂志文章,评审

    doi:10.1016/j.jpedsurg.2005.06.034

    authors: Pereira RM,Simões e Silva AC,Leite VH,Lanna JC,Guimarães JT

    更新日期:2005-10-01 00:00:00