In vitro murine posterior frontal suture fate is age-dependent: implications for cranial suture biology.

Abstract:

:In CD-1 mice, the posterior frontal suture (analogous to the human metopic suture) fuses while all other cranial sutures remain patent. In an in vitro organ culture model, the authors previously demonstrated that posterior frontal sutures explanted immediately before the onset of suture fusion (at 25 days old) mimic in vivo physiologic fusion. In the first portion of this study, the authors defined how early in development the posterior frontal suture fuses in their tension-free, serum-free organ culture system by serially analyzing posterior frontal suture fusion from calvariae explanted at different stages of postnatal development. Their results revealed a divergence of suture fate leading to abnormal patency or physiologic fusion between the first and second weeks of life, respectively, despite viability and continued growth of the calvarial explants in vitro. From these data, the authors postulated that the gene expression patterns present in the suture complex at the time of explant may determine whether the posterior frontal suture fuses or remains patent in organ culture. Therefore, to elucidate potentially important differences in gene expression within this "window of opportunity," they performed a cDNA microarray analysis on 5-day-old and 15-day-old posterior frontal and sagittal whole suture complexes corresponding to the age ranges for unsuccessful (1 to 7 days old) and successful (14 to 21 days old) in vitro posterior frontal suture fusion. Overall, their microarray results reveal interesting differential expression patterns of candidate genes in different categories, including angiogenic cytokines and mechanosensitive genes potentially important in cranial suture biology.

journal_name

Plast Reconstr Surg

authors

Song HM,Sahar DE,Fong KD,Nacamuli RP,Fang TD,Mathy JA,Aalami OO,Warren SM,Longaker MT

doi

10.1097/01.prs.0000110203.90911.63

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

1192-204

issue

4

eissn

0032-1052

issn

1529-4242

pii

00006534-200404010-00011

journal_volume

113

pub_type

杂志文章
  • Management of the infected or exposed breast prosthesis: a single surgeon's 15-year experience with 69 patients.

    abstract:BACKGROUND:In 2004, the senior author (S.L.S.) published an algorithm for the management of breast device infection and/or exposure. The purpose of this study was to build on the authors' prior experience by expanding the cohort of patients and to identify risk factors for failed breast device salvage and recurrent inf...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3181d17fff

    authors: Spear SL,Seruya M

    更新日期:2010-04-01 00:00:00

  • An anatomic study for the rectus abdominis myocutaneous flap combined with a vascularized rib.

    abstract::The anatomy of the vascular connections between the eighth intercostal vessels and the deep epigastric vessels was studied in a series of 20 dissections in 10 preserved cadavers to develop the rectus abdominis myocutaneous flap combined with a vascularized rib. The distance between the point where the eighth intercost...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199511000-00015

    authors: Yamamoto Y,Sugihara T,Kuwahara H,Qi F

    更新日期:1995-11-01 00:00:00

  • The identification of novel wound-healing genes through differential display.

    abstract::Effective methods to identify novel genes in complicated dynamic tissue processes are needed in molecular biology research. Traditional techniques primarily target known genes and are inefficient in the pursuit of unknown genes. Here we describe the use of a modified differential display polymerase chain reaction (DD-...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200209010-00011

    authors: Soo C,Sayah DN,Zhang X,Beanes SR,Nishimura I,Dang C,Freymiller E,Ting K

    更新日期:2002-09-01 00:00:00

  • Sequential chimeric anterolateral thigh flap for reconstruction of through-and-through oropharyngeal defects with no suitable neck recipient vessels.

    abstract::The anterolateral thigh flap is currently the frontline choice for head and neck reconstruction. The authors used a chimeric anterolateral thigh flap for reconstruction of a through-and-through oropharyngeal defect. Because of the absence of suitable recipient vessels in the proximity of the defect, the authors recrui...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e3182879f32

    authors: Vanmierlo B,Craggs B,Van Eeckhout G,Zeltzer A,Hamdi M

    更新日期:2013-05-01 00:00:00

  • The Fibula Osteoseptocutaneous Flap: Concise Review, Goal-Oriented Surgical Technique, and Tips and Tricks.

    abstract::The fibula osteoseptocutaneous flap is a workhorse flap for bone reconstruction. Mastery of the flap is essential for a rewarding reconstruction. However, there is no complete work on this versatile flap. The authors provide a concise review of the literature, address the myths and challenges associated with the flap,...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0000000000005065

    authors: Al Deek NF,Kao HK,Wei FC

    更新日期:2018-12-01 00:00:00

  • Clinical applications of the posterior rectus sheath-peritoneal free flap.

    abstract::Soft-tissue injuries involving the dorsum of the hand and foot continue to pose complex reconstructive challenges in terms of function and contour. Requirements for coverage include thin, vascularized tissue that supports skin grafts and at the same time provides a gliding surface for tendon excursion. This article re...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200008000-00013

    authors: Salgado CJ,Orlando GS,Serletti JM

    更新日期:2000-08-01 00:00:00

  • MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts.

    abstract:BACKGROUND:MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression in the progress of proliferation, differentiation, and apoptosis. A keloid is considered to be a type of benign tumor. The exact contribution of miRNAs in keloid fibroblasts remains largely unknown. METHODS:Loss and gain of f...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000000577

    authors: Liu Y,Wang X,Yang D,Xiao Z,Chen X

    更新日期:2014-10-01 00:00:00

  • Experimental effects of heparin or magnesium sulfate on the patency of microvascular anastomoses.

    abstract::Partial amputations of the hind legs were done in 44 rats. The femoral arteries and veins were repaired by microvascular techniques. The systemic use of heparin, the local use of magnesium sulfate, and the combined use of the two drugs, were evaluated as to their influence on preventing thrombosis in these microvascul...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197505000-00018

    authors: Engrav LH,Benjamin CI,Crandall H,Perry JF

    更新日期:1975-05-01 00:00:00

  • The role of emergent exploration in free-tissue transfer: a review of 150 consecutive cases.

    abstract::One-hundred and fifty consecutive free-tissue transfers were reviewed to evaluate the role of emergent exploration in flap survival. Eleven flaps exhibited signs of circulatory failure between 1 hour and 6 days postoperatively and required return to the operating room. In eight patients the preoperative diagnosis was ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:

    authors: Hidalgo DA,Jones CS

    更新日期:1990-09-01 00:00:00

  • Modified towel-clamp technique to effect reduction of displaced mandible fractures.

    abstract::We report a technique that uses a modified standard towel clamp, allowing a single surgeon to perform and maintain an anatomic reduction of displaced mandible fractures simultaneous with the application of internal fixation. The reduced convergent angle of the modified towel clamp allows bicortical engagement of the c...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200002000-00033

    authors: Rogers GF,Sargent LA

    更新日期:2000-02-01 00:00:00

  • Microvascular Reconstruction of the Nose with the Radial Forearm Flap: A 17-Year Experience in 47 Patients.

    abstract:BACKGROUND:Microvascular reconstruction of the nose was pioneered in China in the early 1970s using the radial forearm flap. Since then, different flaps, methods, and flap designs have been used to improve outcomes. Microvascular tissue transfer has become the first step of multistage reconstruction, which includes reb...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005777

    authors: Salibian AH,Menick FJ,Talley J

    更新日期:2019-07-01 00:00:00

  • Expansion of the socket and orbit for congenital clinical anophthalmia.

    abstract:BACKGROUND:Congenital clinical anophthalmia requires fitting an artificial eye, achieving a pleasing aspect of the palpebral apparatus, and stimulating growth of the orbit, as well as of the entire midface. METHODS:Out of 25 patients with clinical anophthalmia, 22 were treated according to a new protocol (first descri...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000181653.38200.eb

    authors: Gundlach KK,Guthoff RF,Hingst VH,Schittkowski MP,Bier UC

    更新日期:2005-10-01 00:00:00

  • The Modified Sliding Alar Cartilage Flap: A Novel Way to Preserve the Internal Nasal Valve as Illustrated by Three-Dimensional Modeling.

    abstract:BACKGROUND:Preservation of the scroll area is essential when performing rhinoplasty to achieve a good functional outcome. This is of particular concern with tip-plasty procedures. The objectives of this study were (1) to describe a novel tip-plasty procedure consisting of sliding the cephalic portion of the alar cartil...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000005991

    authors: Racy E,Fanous A,Pressat-Laffouilhere T,Benmoussa N

    更新日期:2019-09-01 00:00:00

  • Mechanisms of murine cranial suture patency mediated by a dominant negative transforming growth factor-beta receptor adenovirus.

    abstract::Using a physiologic model of mouse cranial suture fusion, the authors' laboratory has previously demonstrated that transforming growth factor (TGF)-betas appear to be more abundantly expressed in the suture complex of the fusing posterior frontal compared with the patent sagittal suture. Furthermore, the authors have ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000117363.43699.5b

    authors: Song HM,Fong KD,Nacamuli RP,Warren SM,Fang TD,Mathy JA,Cowan CM,Aalami OO,Longaker MT

    更新日期:2004-05-01 00:00:00

  • Selection of topical antimicrobial agents for cultured skin for burns by combined assessment of cellular cytotoxicity and antimicrobial activity.

    abstract::Cultured epidermal skin has become an adjunctive therapy for treatment of major burn injuries, but its effectiveness is greatly limited due to destruction by microbial contamination. To evaluate candidate drugs for use with cultured skin, a combined cytotoxicity-antimicrobial assay system was developed for determinati...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199309000-00018

    authors: Boyce ST,Holder IA

    更新日期:1993-09-01 00:00:00

  • Rhinoplasty Using Three-Dimensional Analysis and Simulation.

    abstract::Treatment of nasal deformity and obstruction requires analysis, planning, and precise execution of rhinoplasty techniques. When performed well, rhinoplasty is a powerful tool for achieving appealing nasal morphology and optimizing function. This article aims to highlight an open approach to septorhinoplasty using a nu...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006687

    authors: Singh A,Maniskas SA,Bruckman KC,Steinbacher DM

    更新日期:2020-04-01 00:00:00

  • Decision-Making in Middle Vault Reconstruction following Dorsal Hump Reduction in Primary Rhinoplasty.

    abstract:BACKGROUND:Dorsal hump reduction during open rhinoplasty disrupts the continuity between the upper lateral cartilages and the dorsal septum. Options to reconstitute the midvault include primary closure of the upper lateral cartilages to the dorsal aspect of the septum, placement of spreader grafts, and creation of spre...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000006850

    authors: Avashia YJ,Marshall AP,Allori AC,Rohrich RJ,Marcus JR

    更新日期:2020-06-01 00:00:00

  • Gluteal fold V-Y advancement flap for vulvar and vaginal reconstruction: a new flap.

    abstract:BACKGROUND:Soft-tissue reconstruction following vulvar cancer resection is a difficult challenge because of the functional, locational, and cosmetic importance of this region. Although numerous flaps have been designed for vulvar reconstruction, each has its disadvantages. METHODS:The authors introduce the gluteal fol...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.prs.0000227683.47836.28

    authors: Lee PK,Choi MS,Ahn ST,Oh DY,Rhie JW,Han KT

    更新日期:2006-08-01 00:00:00

  • Untreated hemangiomas: growth pattern and residual lesions.

    abstract:BACKGROUND:Hemangiomas of infancy can give rise to alarm because of their rapid growth and occasional dramatic appearance. The objective of this study was to investigate the growth pattern of hemangiomas and risk factors for residual lesions. METHODS:A follow-up study was performed of patients with hemangiomas that we...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318208d2ac

    authors: Bauland CG,Lüning TH,Smit JM,Zeebregts CJ,Spauwen PHM

    更新日期:2011-04-01 00:00:00

  • Relevant Surgical Anatomy of Pterygomaxillary Dysjunction in Le Fort III Osteotomy.

    abstract:BACKGROUND:Le Fort III osteotomy represents the foundation of surgical correction for midface hypoplasia. One serious complication of Le Fort III osteotomy is severing the internal maxillary artery or its branches during osteotome advancement for pterygomaxillary dysjunction. This study sought to characterize the relev...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000003084

    authors: Orra S,Tierney WS,Capone AC,Gharb BB,Papay FA,Doumit G

    更新日期:2017-03-01 00:00:00

  • Anatomical Understanding of Target Subcutaneous Tissue Layer for Thinning Procedures in Thoracodorsal Artery Perforator, Superficial Circumflex Iliac Artery Perforator, and Anterolateral Thigh Perforator Flaps.

    abstract:BACKGROUND:Thinned perforator flaps, reported techniques, and degree of thinning differ by study. This study investigated the anatomy of subcutaneous tissue according to the varying fattiness and identified which component and how much of the subcutaneous tissue layer needed to be excluded to meet target flap thickness...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0000000000004619

    authors: Kim SY,Lee YJ,Mun GH

    更新日期:2018-08-01 00:00:00

  • The value of preoperative Doppler sonography for planning free perforator flaps.

    abstract::The individual perforating vessels have a high degree of anatomical variation, therefore it is desirable to conduct a careful examination of them before undertaking a perforator flap operation. Because locating the vessels beforehand makes performing the operative procedure much easier, the aim of the present study wa...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200006000-00011

    authors: Giunta RE,Geisweid A,Feller AM

    更新日期:2000-06-01 00:00:00

  • Assessment of bilateral cleft lip nose deformity: a comparison of results as judged by cleft surgeons and laypersons.

    abstract::Reconstruction of bilateral cleft lip nose deformity is difficult and the outcome is inconsistent. This study was conducted to evaluate the gross outcome and the difference in the assessment of nasal appearance as judged by two groups of raters, cleft surgeons and laypersons. Sixty-four patients with bilateral cleft l...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-200209010-00001

    authors: Lo LJ,Wong FH,Mardini S,Chen YR,Noordhoff MS

    更新日期:2002-09-01 00:00:00

  • The evolution of techniques for reconstruction of full-thickness cheek defects.

    abstract::Our experience with 20 full-thickness cheek reconstruction in 17 patients over the past 27 years is presented. The evolution of techniques for management of full-thickness cheek defects reflects our gradual appreciation of the longitudinal artery concept within axial and musculocutaneous flap units. During the 1950s, ...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-198209000-00004

    authors: Bunkis J,Mulliken JB,Upton J,Murray JE

    更新日期:1982-09-01 00:00:00

  • Aneurysmal bone cyst of the orbit associated with fibrous dysplasia.

    abstract::Aneurysmal bone cyst is a rare but recognized osseous lesion of the orbit. We report the presentation, treatment, and postoperative course of an orbital aneurysmal bone cyst in a patient with McCune-Albright syndrome. To our knowledge, this report represents the first description of aneurysmal bone cyst of the orbit i...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-199508000-00029

    authors: Lucarelli MJ,Bilyk JR,Shore JW,Rubin PA,Yaremchuk MJ

    更新日期:1995-08-01 00:00:00

  • Patient-guided peripheral nerve exploration for the management of chronic localized pain.

    abstract:UNLABELLED:This technique represents a surgical adjunct for the management of chronic, localized pain in patients who continue to have pain despite exhaustive prior evaluation and treatment. The patient-guided approach was used in 10 patients referred with "intractable pain" and yielded good to excellent results in all...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,评审

    doi:10.1097/PRS.0b013e318221dc12

    authors: Souza JM,Nystrom AN,Dumanian GA

    更新日期:2012-01-01 00:00:00

  • Free autogenous transplants in preformed pseudosheath silicone rubber pockets.

    abstract::This investigation suggests that free autogenous grafts, when placed in preformed silicone rubber pseudosheath pockets, will survive as well, if not better, than in delayed or immediate surgical pockets. This supports the clinical assumption that silicone rubber implants can be used and exchanged periodically for larg...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/00006534-197612000-00008

    authors: Thomson HG,Vanderby MB

    更新日期:1976-12-01 00:00:00

  • Shaped versus Round Implants in Breast Reconstruction: A Multi-Institutional Comparison of Surgical and Patient-Reported Outcomes.

    abstract:BACKGROUND:Since the 2012 approval of shaped implants, their use in breast reconstruction has increased in the United States. However, large-scale comparisons of complications and patient-reported outcomes are lacking. The authors endeavored to compare surgical and patient-reported outcomes across implant types. METHO...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/PRS.0000000000003238

    authors: Khavanin N,Clemens MW,Pusic AL,Fine NA,Hamill JB,Kim HM,Qi J,Wilkins EG,Kim JYS

    更新日期:2017-05-01 00:00:00

  • Evaluation of plastic surgery training programs: integrated/combined versus independent.

    abstract:BACKGROUND:The authors aimed to differentiate between combined/integrated and independent (traditional) methods of plastic surgery training with regard to quality of trainees, caliber of graduates, and practice or career outcomes once graduated. METHODS:To compare combined/integrated with independent residency program...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/PRS.0b013e318254b3d0

    authors: Roostaeian J,Fan KL,Sorice S,Tabit CJ,Liao E,Rahgozar P,Tanna N,Bradley JP

    更新日期:2012-07-01 00:00:00

  • Extended approach to the vascular pedicle of the gracilis muscle flap: anatomical and clinical study.

    abstract::Dissection of the proximal gracilis vascular pedicle proceeds in a dark tunnel-like space deep to the adductor longus. With the application of a previously described technique for an extended approach to the lateral arm free flap, the authors describe a novel technique that improves observation and thus facilitates di...

    journal_title:Plastic and reconstructive surgery

    pub_type: 杂志文章

    doi:10.1097/01.PRS.0000060114.95065.C5

    authors: Hasen KV,Gallegos ML,Dumanian GA

    更新日期:2003-06-01 00:00:00