Identification of the calcium-binding protein calgranulin in the matrix of struvite stones.

Abstract:

:The identification of calcium-binding proteins in urine and kidney stones has led to a closer look at the role of matrix proteins in urolithiasis. We analyzed five struvite stones for protein content and identified two bands (8 and 14 KDa) that were confirmed by gel electrophoresis and amino acid sequencing to be calgranulin. This protein, which is known by several other names, has bacteriostatic antifungal activity. Its role in the formation of struvite stones warrants further investigation.

journal_name

J Endourol

journal_title

Journal of endourology

authors

Bennett J,Dretler SP,Selengut J,Orme-Johnson WH

doi

10.1089/end.1994.8.95

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

95-8

issue

2

eissn

0892-7790

issn

1557-900X

journal_volume

8

pub_type

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