Mononuclear leukocyte ADP-ribosylation as an indicator of immune function in malignant-glioma patients treated with betamethasone for cerebral edema.


:Glioma patients receiving corticosteroids (16 mg/day betamethasone) were examined for evidence of immune cell dysfunction by using quantitative estimates of adenosine diphosphate (ADP)-ribosylation in peripheral mononuclear leukocytes as the physiological indicator. The duration of daily treatment with corticosteroids varied from 0 to 35 days at the time of collection of the blood samples. Even after adjustment for covariate factors such as age, sex, smoking habits, alcohol use, antiepileptic medications, and tumor grade, there still remained a highly significant dose-dependent inverse relationship between constitutive and hydrogen peroxide-induced mononuclear leukocyte ADP-ribosylation levels and the duration of corticosteroid treatment (beta coefficients -0.40 and -0.29, respectively; p less than 0.03). No other variable under consideration significantly influenced ADP-ribosylation levels after statistical adjustment. These data support a mutual interdependence of mononuclear leukocyte ADP-ribosylation and corticosteroid-induced immune cell dysfunction in vivo.


J Neurosurg


Journal of neurosurgery


Pero RW,Salford LG,Strömblad LG,Andersson C




Has Abstract


1992-10-01 00:00:00












  • Corpus callosotomy performed with laser interstitial thermal therapy.

    abstract:OBJECTIVE:Corpus callosotomy is a palliative procedure that is effective at reducing seizure burden in patients with medically refractory epilepsy. The procedure is traditionally performed via open craniotomy with interhemispheric microdissection to divide the corpus callosum. Concerns for morbidity associated with cra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Roland JL,Akbari SHA,Salehi A,Smyth MD

    更新日期:2019-12-13 00:00:00

  • Predictors of hospital-associated complications prolonging ICU stay in patients with low-grade aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:The authors sought to determine the predictors of late neurological and hospital-acquired medical complications (HACs) in patients with low-grade aneurysmal subarachnoid hemorrhage (aSAH). METHODS:The authors conducted a retrospective study of 424 patients with low-grade aSAH admitted to their institution fr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mouchtouris N,Lang MJ,Barkley K,Barros G,Turpin J,Sweid A,Starke RM,Chalouhi N,Jabbour P,Rosenwasser RH,Tjoumakaris S

    更新日期:2019-05-03 00:00:00

  • Hemichorea due to hemodynamic ischemia associated with extracranial carotid artery stenosis. Report of two cases.

    abstract::In this paper the authors describe two patients with recurrent hemiparesis and limb shaking that gradually progressed to hemichorea. Cerebral angiography confirmed severe unilateral internal carotid artery stenosis (95%) contralateral to the hemichorea. The cerebral blood flow, assessed using N-isopropyl-p-(iodine-123...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Morigaki R,Uno M,Suzue A,Nagahiro S

    更新日期:2006-07-01 00:00:00

  • In-hospital mortality and length of hospital stay with craniotomy versus craniectomy for acute subdural hemorrhage: a multicenter, propensity score-matched analysis.

    abstract:OBJECTIVE:The optimal surgical treatment for acute subdural hemorrhage (ASDH) remains controversial. The purpose of this study was to compare outcomes in patients who underwent craniotomy with those in patients who underwent decompressive craniectomy for the treatment of ASDH. METHODS:Using the Japan Trauma Data Bank,...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Shibahashi K,Sugiyama K,Tomio J,Hoda H,Morita A

    更新日期:2019-06-21 00:00:00

  • Intracerebellar schwannoma. Case report.

    abstract::A rare case of a solitary schwannoma arising within the cerebellum is reported. The diagnosis was confirmed by electron microscopy and immunohistochemical staining. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sarkar C,Mehta VS,Roy S

    更新日期:1987-07-01 00:00:00

  • Perfusion pressure breakthrough threshold of cerebral autoregulation in the chronically ischemic brain: an experimental study in cats.

    abstract::A study was designed to investigate hyperperfusion syndrome after the restoration of normal cerebral blood flow in a chronically cerebral ischemic state resulting from high-flow arteriovenous malformations or severe carotid stenosis. A fistula between the left distal common carotid artery and the jugular vein was crea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sakaki T,Tsujimoto S,Nishitani M,Ishida Y,Morimoto T

    更新日期:1992-03-01 00:00:00

  • Nitrogen mustard, vincristine, procarbazine, and prednisone as adjuvant chemotherapy in the treatment of medulloblastoma. A Pediatric Oncology Group study.

    abstract::In a randomized postoperative trial, adjuvant post-irradiation chemotherapy, consisting of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP), was tested versus radiation therapy alone for newly diagnosed medulloblastoma in patients between 1 and 21 years of age. Patients treated with irradiation plus ...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Krischer JP,Ragab AH,Kun L,Kim TH,Laurent JP,Boyett JM,Cornell CJ,Link M,Luthy AR,Camitta B

    更新日期:1991-06-01 00:00:00

  • Dysembryoplastic neuroepithelial tumor of the cerebellum and brainstem. Case report.

    abstract::The authors present a case in which dysembryoplastic neuroepithelial tumors (DNETs) occurred in the cerebellum and brainstem of a 44-year-old woman. A magnetic resonance image of the brain revealed multiple cystic lesions in the right cerebellar hemisphere, vermis, tonsil, and brainstem. Partial removal of the tumors ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fujimoto K,Ohnishi H,Tsujimoto M,Hoshida T,Nakazato Y

    更新日期:2000-09-01 00:00:00

  • Microvascularization of Grade I meningiomas: effect on tumor volume, blood loss, and patient outcome.

    abstract::OBJECTIVE Quantitative assessment of tumor microvascularity has the potential to improve prognostication, advance understanding of tumor biology, and help narrow potential molecular therapies. While the role of tumor microvascularity has been widely studied in meningiomas, this study examines both the role of automate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Karsy M,Burnett B,Di Ieva A,Cusimano MD,Jensen RL

    更新日期:2018-03-01 00:00:00

  • Neurosurgery and consciousness: historical sketch and future possibilities.

    abstract::Neurosurgery has played an important role in the development of neuroscience and the science of consciousness. In this paper, the authors reflect on some of the historical contributions of neurosurgeons to the science of consciousness and discuss the ways in which clinical neurosurgery can contribute to the science of...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章


    authors: Hasegawa H,Jamieson GA,Ashkan K

    更新日期:2012-09-01 00:00:00

  • Combined surgical and endovascular treatment of a spontaneous diploic arteriovenous fistula. Case report.

    abstract::The authors report on the case of a 28-year-old woman presenting with an intraosseous arteriovenous fistula (AVF) located in the left parietal bone. The fistula was formed by direct arteriovenous shunts connecting branches of the left middle meningeal and superficial temporal arteries with a parietal diploic vein. Dra...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Burger IM,Tamargo RJ,Broussard J,Gailloud P

    更新日期:2005-07-01 00:00:00

  • Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study.

    abstract::OBJECT Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. METHODS Patients with skull base (anterio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Liouta E,Koutsarnakis C,Liakos F,Stranjalis G

    更新日期:2016-06-01 00:00:00

  • Preoperative prognostic classification system for hemispheric low-grade gliomas in adults.

    abstract:OBJECT:Hemispheric low-grade gliomas (LGGs) have an unpredictable progression and overall survival (OS) profile. As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs. METHODS:The authors conducted a retrospective review wi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chang EF,Smith JS,Chang SM,Lamborn KR,Prados MD,Butowski N,Barbaro NM,Parsa AT,Berger MS,McDermott MM

    更新日期:2008-11-01 00:00:00

  • Anatomic variations of venous sinuses in the region of the torcular Herophili.

    abstract::In this study of 110 cranial cavities from adult cadavers, the superior sagittal sinus was found to divide into two channels. In most cases, the division was associated with a dural partition. Essentially, the variations as observed in this study could be grouped into three types: Type 1 includes those specimens in wh...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Bisaria KK

    更新日期:1985-01-01 00:00:00

  • Compound anterior cranial base fractures: classification using computerized tomography scanning as a basis for selection of patients for dural repair.

    abstract:OBJECT:A classification is proposed to organize anterior cranial base fractures systematically according to their location and size. The goal of this study was to determine whether these two variables, irrespective of cerebrospinal fluid (CSF) rhinorrhea, are related to the long-term risk of posttraumatic meningitis an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Sakas DE,Beale DJ,Ameen AA,Whitwell HL,Whittaker KW,Krebs AJ,Abbasi KH,Dias PS

    更新日期:1998-03-01 00:00:00

  • Open reduction of pediatric atlantoaxial rotatory fixation: long-term outcome study with functional measurements.

    abstract:OBJECT:Atlantoaxial rotatory fixation (AARF) is an uncommon disorder of childhood in which resolution usually occurs spontaneously or after traction therapy. In a minority of children irreducible or chronic fixation develop, and the natural history then usually involves restriction of head on neck movement, abnormal he...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Crossman JE,David K,Hayward R,Crockard HA

    更新日期:2004-03-01 00:00:00

  • Primary visual cortical thickness in correlation with visual field defects in patients with pituitary macroadenomas: a structural 7-Tesla retinotopic analysis.

    abstract:OBJECTIVE:Vision loss remains a debilitating complication of pituitary adenomas, although there is considerable variability in visual impairment before and after decompression surgery. Growing evidence suggests secondary damage to remote visual structures may contribute to vision loss in patients with chiasmatic compre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rutland JW,Delman BN,Huang KH,Verma G,Benson NC,Villavisanis DF,Lin HM,Bederson JB,Chelnis J,Shrivastava RK,Balchandani P

    更新日期:2019-10-18 00:00:00

  • Perioperative complications and neurological outcomes of first and second craniotomies among patients enrolled in the Glioma Outcome Project.

    abstract:OBJECT:In many new clinical trials of patients with malignant gliomas surgical intervention is incorporated as an integral part of tumor-directed interstitial therapies such as gene therapy, biodegradable wafer placement, and immunotherapy. Assessment of toxicity is a major component of evaluating these novel therapeut...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chang SM,Parney IF,McDermott M,Barker FG 2nd,Schmidt MH,Huang W,Laws ER Jr,Lillehei KO,Bernstein M,Brem H,Sloan AE,Berger M,Glioma Outcomes Investigators.

    更新日期:2003-06-01 00:00:00

  • Correlation of thin fibrous cap possessing adipophilin-positive macrophages and intraplaque hemorrhage with high clinical risk for carotid endarterectomy.

    abstract:OBJECT:Preoperative clinical risk classification of carotid artery (CA) stenosis anticipates the outcome of CA intervention. A higher incidence of neurological morbidity was noted after CA stenting (CAS) in patients with medical risks than in those without risks. However, little is known about the correlation between c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hao H,Iihara K,Ishibashi-Ueda H,Saito F,Hirota S

    更新日期:2011-04-01 00:00:00

  • Safe removal of retained ventricular catheters using intraluminal choroid plexus coagulation. Technical note.

    abstract::The authors describe a simple technique that reduces the incidence of retained ventricular catheters and minimizes the risk of life-threatening intraventricular hemorrhage during the removal of an obstructed, adherent ventricular catheter in patients with hydrocephalus. The technique requires no special equipment and ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Whitfield PC,Guazzo EP,Pickard JD

    更新日期:1995-12-01 00:00:00

  • California Association of Neurological Surgeons' Emergency Services Committee report: guidelines for establishment of trauma centers.

    abstract::The CANS supports the concept of organized neurological trauma care consisting of an appropriate amalgamation of prepared communities, institutions, and adequate numbers of committed neurosurgeons. It further supports the guidelines of the ACS regarding institutions designated to receive trauma cases. It opposes manda...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章



    更新日期:1986-10-01 00:00:00

  • Inhibition of growth of established human glioma cell lines by modulators of the protein kinase-C system.

    abstract::The protein kinase-C (PKC) second messenger system contributes to regulation of cell growth and differentiation. This study was undertaken to examine the effects of modulators of the PKC enzyme system on the state of differentiation and proliferation rates of human gliomas in vitro. The administration of the PKC-activ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Couldwell WT,Antel JP,Apuzzo ML,Yong VW

    更新日期:1990-10-01 00:00:00

  • Ischemic complications associated with resection of opercular glioma.

    abstract:OBJECT:Opercular glioma inferolateral to the hand/digit sensorimotor area can be resected safely using a neuronavigation system and functional brain mapping techniques. However, the surgery can still sometimes cause postoperative ischemic complications, the character of which remains unclear. The authors of this study ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kumabe T,Higano S,Takahashi S,Tominaga T

    更新日期:2007-02-01 00:00:00

  • Biomechanical properties of expander compared with conventional screws.

    abstract:OBJECT:A pullout strength biomechanical study was performed in 20 fresh swine vertebral bodies in which titanium expander (Group 1) and conventional screws (Group 2) were placed. METHODS:The screws were inserted into the anterosuperior portion of the anterior spine, and assessment was performed after application of lo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rassi-Neto A,Shimano A

    更新日期:2002-10-01 00:00:00

  • Prospective study of zero drift in fiberoptic pressure monitors used in clinical practice.

    abstract::One hundred and one fiberoptic pressure transducers (59 subdural and 42 ventricular) were studied in 86 patients (some in whom more than one device had been inserted). Only four complications occurred: two transient cerebrospinal fluid leaks after removal and two clinically insignificant intracerebral hematomas. No in...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章


    authors: Bavetta S,Norris JS,Wyatt M,Sutcliffe JC,Hamlyn PJ

    更新日期:1997-06-01 00:00:00

  • Chemotherapy of pediatric brain-stem tumors.

    abstract::Forty-five children harboring brain-stem tumors were treated at the University of California, San Francisco, between 1969 and 1979. Pathological diagnoses were made in 19 patients. All patients received radiation therapy (RT). Thirteen patients received chemotherapy before, during, or immediately after RT. Twenty-four...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Fulton DS,Levin VA,Wara WM,Edwards MS,Wilson CB

    更新日期:1981-06-01 00:00:00

  • Outcome following hindbrain decompression of symptomatic Chiari malformations in children previously treated with myelomeningocele closure and shunts.

    abstract::Between 1975 and 1989, 25 children treated with myelomeningocele closure and shunting for hydrocephalus at the Children's Hospital of Pittsburgh developed progressive lower brain-stem dysfunction from their Chiari malformation. Retrospective univariate and multivariate analyses of these cases were undertaken to assess...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pollack IF,Pang D,Albright AL,Krieger D

    更新日期:1992-12-01 00:00:00

  • Arachnoid membranes in the posterior half of the incisural space: an inverted Liliequist membrane-like arachnoid complex.

    abstract:OBJECT:The aim of this study was to describe the similarity of configuration between the arachnoid complex in the posterior half of the incisural space and the Liliequist membrane. METHODS:Microsurgical dissection and anatomical observation were performed in 20 formalin-fixed adult cadaver heads. The origin, distribut...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Zhang XA,Qi ST,Fan J,Huang GL,Peng JX

    更新日期:2014-08-01 00:00:00

  • Endoscopic endonasal medial-to-lateral and transorbital lateral-to-medial optic nerve decompression: an anatomical study with surgical implications.

    abstract::OBJECTIVE Different surgical routes have been used over the years to achieve adequate decompression of the optic nerve in its canal including, more recently, endoscopic approaches performed either through the endonasal corridor or the transorbital one. The present study aimed to detail and quantify the amount of bone ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Di Somma A,Cavallo LM,de Notaris M,Solari D,Topczewski TE,Bernal-Sprekelsen M,Enseñat J,Prats-Galino A,Cappabianca P

    更新日期:2017-07-01 00:00:00

  • Reduction of hemorrhage risk after stereotactic radiosurgery for cavernous malformations.

    abstract::The benefits of radiosurgery for cavernous malformations are difficult to assess because of the unclear natural history of this vascular lesion, the inability to image malformation vessels, and the lack of an imaging technique that defines "cure." The authors selected for radiosurgery 47 patients who harbored a hemorr...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kondziolka D,Lunsford LD,Flickinger JC,Kestle JR

    更新日期:1995-11-01 00:00:00