Abstract:
:The geometry and mechanical properties of the human erythrocyte membrane cytoskeleton are investigated by a computer simulation in which the cytoskeleton is represented by a network of polymer chains. Four elastic moduli as well as the area and thickness are predicted for the chain network as a function of temperature and the number of segments in each chain. Comparisons are made with mean field arguments to examine the importance of steric interactions in determining network properties. Applied to the red blood cell, the simulation predicts that in the bilayer plane the membrane cytoskeleton has a shear modulus of 10 +/- 2 x 10(-6) J/m2 and an areal compression modulus of 17 +/- 2 x 10(-6) J/m2. The volume compression modulus and the transverse Young's modulus of the cytoskeleton are predicted to be 1.2 +/- 0.1 x 10(3) J/m3 and 2.0 +/- 0.1 x 10(3) J/m3, respectively. Elements of the cytoskeleton are predicted to have a mean displacement from the bilayer plane of 15 nm. The simulation agrees with some, but not all, of the shear modulus measurements. The other predicted moduli have not been measured.
journal_name
Biophys Jjournal_title
Biophysical journalauthors
Boal DHdoi
10.1016/S0006-3495(94)80511-9subject
Has Abstractpub_date
1994-08-01 00:00:00pages
521-9issue
2eissn
0006-3495issn
1542-0086pii
S0006-3495(94)80511-9journal_volume
67pub_type
杂志文章abstract::We study DNA supercoiling in a quantitative fashion by micromanipulating single linear DNA molecules with a magnetic field gradient. By anchoring one end of the DNA to multiple sites on a magnetic bead and the other end to multiple sites on a glass surface, we were able to exert torsional control on the DNA. A rotatin...
journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(98)77908-1
更新日期:1998-04-01 00:00:00
abstract::A new method, weighted-ensemble Brownian dynamics, is proposed for the simulation of protein-association reactions and other events whose frequencies of outcomes are constricted by free energy barriers. The method features a weighted ensemble of trajectories in configuration space with energy levels dictating the prop...
journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(96)79552-8
更新日期:1996-01-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(98)77731-8
更新日期:1998-12-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(81)84785-6
更新日期:1981-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.103.032706
更新日期:2004-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.103.039123
更新日期:2004-09-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(97)78674-0
更新日期:1997-01-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(94)80686-1
更新日期:1994-11-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.105.066241
更新日期:2005-12-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:1989-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(98)77517-4
更新日期:1998-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(67)86594-9
更新日期:1967-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.106.099838
更新日期:2007-03-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(93)81043-9
更新日期:1993-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.107.107557
更新日期:2007-09-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2019.07.020
更新日期:2019-08-20 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.105.073858
更新日期:2006-03-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2017.05.023
更新日期:2017-07-11 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2009.07.018
更新日期:2009-10-07 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(03)74895-4
更新日期:2003-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1529/biophysj.107.123851
更新日期:2008-04-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(96)79647-9
更新日期:1996-02-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2010.10.010
更新日期:2010-12-15 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(90)82570-4
更新日期:1990-03-01 00:00:00
abstract::Viral fusion peptides are short N-terminal regions of type-1 viral fusion proteins that are critical for virus entry. Although the importance of viral fusion peptides in virus-cell membrane fusion is established, little is known about how they function. We report the effects of wild-type (WT) hemagglutinin (HA) fusion...
journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2013.10.010
更新日期:2013-12-03 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(02)75378-2
更新日期:2002-01-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/S0006-3495(80)85080-6
更新日期:1980-04-01 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2008.11.023
更新日期:2009-02-18 00:00:00
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journal_title:Biophysical journal
pub_type: 杂志文章
doi:10.1016/j.bpj.2011.07.009
更新日期:2011-08-17 00:00:00