An estimation of noise levels in HMPAO RCBF SPECT images using simulation and phantom data; comparison with results obtained from repeated normal controls.

Abstract:

:The purpose of this work was to determine noise levels in HMPAO RCBF SPECT images. Eight simulated images of a uniform sphere of activity were made at each of three different count levels. Three images of the Amersham brain phantom were obtained at each of three count levels, roughly corresponding to the simulation levels. Image reconstruction involved a modified Shepp-Logan filter with and without attenuation correction. The scaling constant in the Budinger equation was shown to vary little over the count range used with a mean value of 23 for uncorrected phantom data and 27 for corrected phantom data, corresponding to RMS noise levels of 7%-15%. The variance due to noise was calculated as a percentage of the variance obtained for 53 normal control studies following image registration and normalization. Values of 54% for uncorrected images and 67% for corrected images were obtained. For 10 normal controls a repeated study was performed. The ratio of within-subject to (single sample) between-subject variance was determined as 73% for uncorrected images and 78% for corrected images.

journal_name

Phys Med Biol

authors

Houston AS,Kemp PM,Griffiths PT,MacLeod MA

doi

10.1088/0031-9155/39/5/006

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

873-84

issue

5

eissn

0031-9155

issn

1361-6560

journal_volume

39

pub_type

临床试验,杂志文章
  • Comparison of in vivo scintillation probes and gamma cameras for detection of small, deep tumours.

    abstract::An in vivo probe was compared with a gamma camera for the task of detecting radiolabelled tumour models in a water phantom. The probe, which contained a 1 cm diameter NaI(T1) detector, was designed and used by us for surgical staging studies of gynaecological patients. Tumours were spherical sources of different sizes...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/34/6/008

    authors: Barber HB,Barrett HH,Woolfenden JM,Myers KJ,Hickernell TS

    更新日期:1989-06-01 00:00:00

  • Using mathematical morphology to determine left ventricular contours.

    abstract::The aim of this study is to investigate the use of mathematical morphology for the determination of left ventricular contours in scintigraphic images using multigated radionuclide angiography. We have developed a completely automatic method that first restores the image with a Wiener filter, then finds the region wher...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/38/12/012

    authors: Pladellorens J,Serrat J,Castell A,Yzuel MJ

    更新日期:1993-12-01 00:00:00

  • Intraventricular vector flow mapping-a Doppler-based regularized problem with automatic model selection.

    abstract::We propose a regularized least-squares method for reconstructing 2D velocity vector fields within the left ventricular cavity from single-view color Doppler echocardiographic images. Vector flow mapping is formulated as a quadratic optimization problem based on an [Formula: see text]-norm minimization of a cost functi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa7fe7

    authors: Assi KC,Gay E,Chnafa C,Mendez S,Nicoud F,Abascal JFPJ,Lantelme P,Tournoux F,Garcia D

    更新日期:2017-08-11 00:00:00

  • An investigation of a PRESAGE® in vivo dosimeter for brachytherapy.

    abstract::Determining accurate in vivo dosimetry in brachytherapy treatment with high dose gradients is challenging. Here we introduce, investigate, and characterize a novel in vivo dosimeter and readout technique with the potential to address this problem. A cylindrical (4 mm × 20 mm) tissue equivalent radiochromic dosimeter P...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/14/3893

    authors: Vidovic AK,Juang T,Meltsner S,Adamovics J,Chino J,Steffey B,Craciunescu O,Oldham M

    更新日期:2014-07-21 00:00:00

  • In vivo evaluation of a new system for 3D computerized angiography.

    abstract::A new system has been designed and built to validate the concept of 3D computerized angiography (CA). This system can acquire a set of 2D digital subtracted angiography images while rotating around a patient and then, using these images, reconstruct a 3D representation of the opacified vasculature. The design principl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/3/020

    authors: Saint-Félix D,Trousset Y,Picard C,Ponchut C,Roméas R,Rougée A

    更新日期:1994-03-01 00:00:00

  • Modelling the electrical properties of tissue as a porous medium.

    abstract::Models of the electrical properties of biological tissue have been the subject of many studies. These models have sought to explain aspects of the dielectric dispersion of tissue. This paper develops a mathematical model of the complex permittivity of tissue as a function of frequency f, in the range 10(4) < f < 10(7)...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/23/016

    authors: Smye SW,Evans CJ,Robinson MP,Sleeman BD

    更新日期:2007-12-07 00:00:00

  • Dielectric properties of supercooled cryoprotectant agents.

    abstract::The dielectric properties of glycerol, propylene glycol, ethylene glycol and dimethyl sulphoxide have been measured in various aqueous concentrations generally sufficient to allow supercooling rather than freezing. The temperature range investigated is from -80 degrees C to +20 degrees C and the frequency range is 100...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/10/014

    authors: Michelson SC,Evans S

    更新日期:1996-10-01 00:00:00

  • Is it necessary to plan with safety margins for actively scanned proton therapy?

    abstract::In radiation therapy, a plan is robust if the calculated and the delivered dose are in agreement, even in the case of different uncertainties. The current practice is to use safety margins, expanding the clinical target volume sufficiently enough to account for treatment uncertainties. This, however, might not be idea...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/14/011

    authors: Albertini F,Hug EB,Lomax AJ

    更新日期:2011-07-21 00:00:00

  • Evaluation of inverse methods and head models for EEG source localization using a human skull phantom.

    abstract::We used a real-skull phantom head to investigate the performances of representative methods for EEG source localization when considering various head models. We describe several experiments using a montage with current sources located at multiple positions and orientations inside a human skull filled with a conductive...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/1/306

    authors: Baillet S,Riera JJ,Marin G,Mangin JF,Aubert J,Garnero L

    更新日期:2001-01-01 00:00:00

  • Improved tumour response prediction with equivalent uniform dose in pre-clinical study using direct intratumoural infusion of liposome-encapsulated ¹⁸⁶Re radionuclides.

    abstract::Crucial to all cancer therapy modalities is a strong correlation between treatment and effect. Predictability of therapy success/failure allows for the optimization of treatment protocol and aids in the decision of whether additional treatment is necessary to prevent tumour progression. This work evaluated the relatio...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/17/016

    authors: Hrycushko BA,Ware S,Li S,Bao A

    更新日期:2011-09-07 00:00:00

  • Volume estimation of low-contrast lesions with CT: a comparison of performances from a phantom study, simulations and theoretical analysis.

    abstract::Measurements of lung nodule volume with multi-detector computed tomography (MDCT) have been shown to be more accurate and precise compared to conventional lower dimensional measurements. Quantifying the size of lesions is potentially more difficult when the object-to-background contrast is low as with lesions in the l...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/2/671

    authors: Li Q,Gavrielides MA,Zeng R,Myers KJ,Sahiner B,Petrick N

    更新日期:2015-01-21 00:00:00

  • An automated, fast and accurate registration method to link stranded seeds in permanent prostate implants.

    abstract::The geometry of a permanent prostate implant varies over time. Seeds can migrate and edema of the prostate affects the position of seeds. Seed movements directly influence dosimetry which relates to treatment quality. We present a method that tracks all individual seeds over time allowing quantification of seed moveme...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/20/N391

    authors: Westendorp H,Nuver TT,Moerland MA,Minken AW

    更新日期:2015-10-21 00:00:00

  • Adaptation and applications of a realistic digital phantom based on patient lung tumor trajectories.

    abstract::Digital phantoms continue to play a significant role in modeling and characterizing medical imaging. The currently available XCAT phantom incorporates both the flexibility of mathematical phantoms and the realistic nature of voxelized phantoms. This phantom generates images based on a regular breathing pattern and can...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/11/3597

    authors: Mishra P,St James S,Segars WP,Berbeco RI,Lewis JH

    更新日期:2012-06-07 00:00:00

  • A framework for organ dose estimation in x-ray angiography and interventional radiology based on dose-related data in DICOM structured reports.

    abstract::Although interventional x-ray angiography (XA) procedures involve relatively high radiation doses that can lead to deterministic tissue reactions in addition to stochastic effects, convenient and accurate estimation of absorbed organ doses has traditionally been out of reach. This has mainly been due to the absence of...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/8/3063

    authors: Omar A,Bujila R,Fransson A,Andreo P,Poludniowski G

    更新日期:2016-04-21 00:00:00

  • ICRP Publication 116--the first ICRP/ICRU application of the male and female adult reference computational phantoms.

    abstract::ICRP Publication 116 on 'Conversion coefficients for radiological protection quantities for external radiation exposures', provides fluence-to-dose conversion coefficients for organ-absorbed doses and effective dose for various types of external exposures (ICRP 2010 ICRP Publication 116). The publication supersedes th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/18/5209

    authors: Petoussi-Henss N,Bolch WE,Eckerman KF,Endo A,Hertel N,Hunt J,Menzel HG,Pelliccioni M,Schlattl H,Zankl M

    更新日期:2014-09-21 00:00:00

  • Radioluminescence in biomedicine: physics, applications, and models.

    abstract::The electromagnetic spectrum contains different frequency bands useful for medical imaging and therapy. Short wavelengths (ionizing radiation) are commonly used for radiological and radionuclide imaging and for cancer radiation therapy. Intermediate wavelengths (optical radiation) are useful for more localized imaging...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/1361-6560/aaf4de

    authors: Klein JS,Sun C,Pratx G

    更新日期:2019-02-06 00:00:00

  • Projection x-ray imaging with photon energy weighting: experimental evaluation with a prototype detector.

    abstract::The signal-to-noise ratio (SNR) in x-ray imaging can be increased using a photon counting detector which could allow for rejecting electronics noise and for weighting x-ray photons according to their energies. This approach, however, was not feasible for a long time because photon counting x-ray detectors with very hi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/16/009

    authors: Shikhaliev PM

    更新日期:2009-08-21 00:00:00

  • Automatic T1 bladder tumor detection by using wavelet analysis in cystoscopy images.

    abstract::Correct classification of cystoscopy images depends on the interpreter's experience. Bladder cancer is a common lesion that can only be confirmed by biopsying the tissue, therefore, the automatic identification of tumors plays a significant role in early stage diagnosis and its accuracy. To our best knowledge, the use...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa3af

    authors: Freitas NR,Vieira PM,Lima E,Lima CS

    更新日期:2018-02-02 00:00:00

  • Estimating cancer risk from dental cone-beam CT exposures based on skin dosimetry.

    abstract::The aim of this study was to measure entrance skin doses on patients undergoing cone-beam computed tomography (CBCT) examinations, to establish conversion factors between skin and organ doses, and to estimate cancer risk from CBCT exposures. 266 patients (age 8-83) were included, involving three imaging centres. CBCT ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/14/3877

    authors: Pauwels R,Cockmartin L,Ivanauskaité D,Urbonienė A,Gavala S,Donta C,Tsiklakis K,Jacobs R,Bosmans H,Bogaerts R,Horner K,SEDENTEXCT Project Consortium.

    更新日期:2014-07-21 00:00:00

  • Exploration and application of phenomenological RBE models for proton therapy.

    abstract::The relative biological effectiveness (RBE) of protons varies with multiple physical and biological factors. Phenomenological RBE models have been developed to include such factors in the estimation of a variable RBE, in contrast to the clinically applied constant RBE of 1.1. In this study, eleven published phenomenol...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad9db

    authors: Rørvik E,Fjæra LF,Dahle TJ,Dale JE,Engeseth GM,Stokkevåg CH,Thörnqvist S,Ytre-Hauge KS

    更新日期:2018-09-13 00:00:00

  • Evaluation of a novel triple-channel radiochromic film analysis procedure using EBT2.

    abstract::A novel approach to read out radiochromic film was introduced recently by the manufacturer of GafChromic film. In this study, the performance of this triple-channel film dosimetry method was compared against the conventional single-red-channel film dosimetry procedure, with and without inclusion of a pre-irradiation (...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/13/4353

    authors: van Hoof SJ,Granton PV,Landry G,Podesta M,Verhaegen F

    更新日期:2012-07-07 00:00:00

  • New materials for dielectric simulation of tissues.

    abstract::Two novel materials have been developed to simulate the dielectric properties of human muscle and fat at 1000 MHz. These materials, which are based on ethanediol set with gelatine, are easily made and have good mechanical properties. The complex permittivity, epsilon *, of each material was measured with an open-ended...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/36/12/002

    authors: Robinson MP,Richardson MJ,Green JL,Preece AW

    更新日期:1991-12-01 00:00:00

  • In vivo evaluation of the elastic anisotropy of the human Achilles tendon using shear wave dispersion analysis.

    abstract::Non-invasive evaluation of the Achilles tendon elastic properties may enhance diagnosis of tendon injury and the assessment of recovery treatments. Shear wave elastography has shown to be a powerful tool to estimate tissue mechanical properties. However, its applicability to quantitatively evaluate tendon stiffness is...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/3/505

    authors: Brum J,Bernal M,Gennisson JL,Tanter M

    更新日期:2014-02-07 00:00:00

  • Kinetic parameter estimation from SPECT cone-beam projection measurements.

    abstract::Kinetic parameters are commonly estimated from dynamically acquired nuclear medicine data by first reconstructing a dynamic sequence of images and subsequently fitting the parameters to time-activity curves generated from regions of interest overlaid upon the image sequence. Biased estimates can result from images rec...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/4/024

    authors: Huesman RH,Reutter BW,Zeng GL,Gullberg GT

    更新日期:1998-04-01 00:00:00

  • UWB pulse propagation into human tissues.

    abstract::In this paper the propagation of a UWB pulse into a layered model of the human body is studied to characterize absorption and reflection of the UWB signal due to the different body tissues. Several time behaviours for the incident UWB pulse are considered and compared with reference to the feasibility of breath and he...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/24/8689

    authors: Cavagnaro M,Pittella E,Pisa S

    更新日期:2013-12-21 00:00:00

  • Modelling of electron contamination in clinical photon beams for Monte Carlo dose calculation.

    abstract::The purpose of this work is to model electron contamination in clinical photon beams and to commission the source model using measured data for Monte Carlo treatment planning. In this work, a planar source is used to represent the contaminant electrons at a plane above the upper jaws. The source size depends on the di...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/12/013

    authors: Yang J,Li JS,Qin L,Xiong W,Ma CM

    更新日期:2004-06-21 00:00:00

  • Self-adaptive ultrasonic beam amplifiers: application to transcostal shock wave therapy.

    abstract::Ultrasound shock wave therapy is increasingly used for non-invasive surgery. It requires the focusing of very high pressure amplitude in precisely controlled focal spots. In transcostal therapy of the heart or the liver, the high impedance mismatch between the bones and surrounding tissues gives rise to strong aberrat...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad9b5

    authors: Robin J,Simon A,Arnal B,Tanter M,Pernot M

    更新日期:2018-09-06 00:00:00

  • Experimental validation of Monte Carlo calculations with a voxelized Rando-Alderson phantom: a study on influence parameters.

    abstract::The development and improvement of techniques for an accurate dose assessment in medical physics is an important task. In this study, we focus on the validation of Monte Carlo calculations, by comparing organ doses assessed experimentally with thermoluminescent detectors in the Rando-Alderson phantom with doses calcul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/20/018

    authors: Struelens L,Vanhavere F,Smans K

    更新日期:2008-10-21 00:00:00

  • Pulsed EPR imaging: image reconstruction using selective acquisition sequences.

    abstract::Pulsed nuclear magnetic resonance imaging (NMRI) apparatus has developed very quickly. On the other hand, the development of apparatus for pulsed electron paramagnetic resonance imaging (EPRI) has been very slow. This fact is due to the extremely reduced relaxation times of the paramagnetic probes. EPR linewidths are ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/6/409

    authors: Di Giuseppe S,Placidi G,Brivati JA,Alecci M,Sotgiu A

    更新日期:1999-06-01 00:00:00

  • Study of the PTW microLion chamber temperature dependence.

    abstract::The use of liquid ionization chambers in radiotherapy has grown during the past few years. While for air ionization chambers the k(TP) correction for air mass density due to pressure and temperature variations is well known, less work has been done on the case of liquid ionization chambers, where there is still the ne...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/11/2705

    authors: Gómez F,González-Castaño D,Díaz-Botana P,Pardo-Montero J

    更新日期:2014-06-07 00:00:00