Hepatic functional reserve in patients with obstructive jaundice: an assessment by the redox tolerance test.

Abstract:

PURPOSE:Hepatic mitochondrial response to oral glucose load (redox tolerance test) was evaluated as an indicator of hepatic functional reserve of patients with obstructive jaundice. PATIENTS AND METHODS:The redox tolerance test was performed in 29 patients with obstructive jaundice before percutaneous transhepatic biliary drainage and 2 weeks after the procedure. RESULTS:The redox tolerance index (RTI) before drainage was not related to conventional parameters other than albumin, but was significantly associated with bilirubin half-life (P < 0.01). Of 19 patients with an RTI > or = 0.5 before drainage, all maintained similar values after drainage and experienced satisfactory clinical courses, even after major surgery. Of 10 patients with an RTI < 0.5 before drainage, 5 showed improvement and 5 deteriorated after drainage. Four of the latter 5 died within 60 days after drainage. The hospital mortality was significantly greater in patients with initial RTI < 0.5 than in patients with RTI > or = 0.5 (P < 0.01). CONCLUSION:The redox tolerance test is useful for evaluating hepatic functional reserve and prognosis in patients with obstructive jaundice.

journal_name

Am J Surg

authors

Tsubono T,Tsukada K,Hatakeyama K

doi

10.1016/S0002-9610(99)80162-7

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

300-3

issue

3

eissn

0002-9610

issn

1879-1883

pii

S0002-9610(99)80162-7

journal_volume

169

pub_type

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