当前位置： SCI文献检索 > JOURNAL OF VASCULAR SURGERY期刊下所有文献 > Inhibition of injury induced intimal hyperplasia by saralasin in rats.

Inhibition of injury induced intimal hyperplasia by saralasin in rats.

Abstract：

:Increasing evidence points toward local production of renin and angiotensinogen in the artery wall. Because angiotensin converting enzyme (ACE) inhibitors have been shown to block intimal hyperplasia after arterial injury in the rat, it has been suggested that angiotensin II is an important mediator of the proliferative response to vascular injury. To prove that previous observations with use of ACE inhibitors are a result of effects on local angiotensin levels versus nonspecific drug effects, we tested the ability of an unrelated drug, the angiotensin II receptor antagonist saralasin, to similarly block intimal hyperplasia after aortic injury in the rat. Balloon catheter aortic denudation was performed in 28 rats pharmacologically treated for 14 days after surgery and split into four groups: group 1, saralasin 360 micrograms/kg/hr intravenously; group two, normal saline 0.5 mm3/hr intravenously; group 3, captopril 100 mg/kg/day orally; and group 4, heparin 50 U/kg/hr intravenously. Animals were killed and aortas were perfusion fixed at physiologic pressure 14 days after denudation. Cross-sectional intima-to-media ratios were calculated by computerized planimetry. Compared with saline controls, saralasin inhibited intimal hyperplasia 45% (p less than 0.001), captopril 59% (p less than 0.001), and heparin 68% (p less than 0.001). A reduction in total intimal area was also evident in animals treated with saralasin (p less than 0.01). Blood pressure in the group treated with captopril decreased from 107.4 +/- 3.9 to 96.3 +/- 4.3 mm Hg (p less than 0.01) after 6 days, whereas saralasin and heparin had no effect on blood pressure. Weight gain during the study was reduced in groups treated with captopril and heparin but not in the group treated with saralasin.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Vasc Surg

journal_title

Journal of vascular surgery

authors

Pan XM,Nelken N,Colyvas N,Rapp JH

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

693-8

issue

4

eissn

0741-5214

issn

1097-6809

pii

0741-5214(92)90017-3

journal_volume

15

pub_type

杂志文章

相关文献

JOURNAL OF VASCULAR SURGERY文献大全
  • Contemporary results of angioplasty-based infrainguinal percutaneous interventions.

    abstract：INTRODUCTION:Although lower-extremity bypass grafting has been the gold standard for infrainguinal revascularization, endovascular therapies have been increasingly applied to avoid operative morbidities. This study addresses the initial results of an implementation of infrainguinal percutaneous transluminal angioplasty...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2005.06.024

    authors： Black JH 3rd,LaMuraglia GM,Kwolek CJ,Brewster DC,Watkins MT,Cambria RP

    更新日期：2005-11-01 00:00:00

  • Timing of repair of blunt thoracic aortic injuries in the thoracic endovascular aortic repair era.

    abstract：OBJECTIVE:Thoracic endovascular aortic repair (TEVAR) is the preferred operative treatment of blunt thoracic aortic injuries (BTAIs). Its use is associated with improved outcomes compared with open surgical repair and nonoperative management. However, the optimal time from injury to repair is unknown and remains a subj...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2020.05.079

    authors： Alarhayem AQ,Rasmussen TE,Farivar B,Lim S,Braverman M,Hardy D,Jenkins DJ,Eastridge BJ,Cestero RF

    更新日期：2020-07-15 00:00:00

  • Ruptured popliteal artery aneurysm.

    abstract：:Popliteal artery aneurysms rarely rupture. We treated a 91-year-old man who presented with a deep venous thrombosis and anemia; rupture of a popliteal artery aneurysm was suspected only after compartment syndrome isolated to the thigh developed as the result of bleeding. Although fasciotomy was required on the basis o...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(98)70251-4

    authors： Illig KA,Eagleton MJ,Shortell CK,Ouriel K,DeWeese JA,Green RM

    更新日期：1998-04-01 00:00:00

  • Infrapopliteal arterial revascularization for critical limb ischemia: is the peroneal artery at the distal third a suitable outflow vessel?

    abstract：PURPOSE:Though the peroneal artery (PA) often remains patent despite disease or occlusion of other infrapopliteal arteries, there is skepticism about using the terminal PA as the outflow tract in distal revascularizations for limb salvage, especially when a patent inframalleolar artery is available. We analyzed our exp...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2008.01.002

    authors： Ballotta E,Da Giau G,Gruppo M,Mazzalai F,Martella B

    更新日期：2008-05-01 00:00:00

  • Visceral stent patency after fenestrated endovascular aneurysm repair using bare-metal stent extensions versus covered stents only.

    abstract：OBJECTIVE:Fenestrated endovascular aneurysm repair (FEVAR) is an alternative to treat complex abdominal aortic aneurysms. Patency of visceral vessels remains high when covered stents are used. The use of distal uncovered stents to prevent kinking has been associated with loss of branch patency. The aim of this study wa...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2019.03.054

    authors： Khoury MK,Timaran DE,Knowles M,Timaran CH

    更新日期：2020-01-01 00:00:00

  • Acute and chronic radiation injury.

    abstract：INTRODUCTION:Although all areas of the body are susceptible to radiation injury, different tissues have varying tolerances for radiation exposure. The goal of this summary is to introduce basic concepts of radiation biology and discuss the effects of radiation on various tissues. METHODS:Reference texts and literature...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2010.06.175

    authors： Brown KR,Rzucidlo E

    更新日期：2011-01-01 00:00:00

  • Hybrid treatment of a giant thoracic aneurysm in a 38 year-old woman.

    abstract：:A 38-year-old woman, with no comorbidities, presented to an outside institution with a 10-cm aortic arch and descending thoracic aortic aneurysm. After an aborted attempt at hybrid repair, she underwent successful, staged repair with zone 1 thoracic endovascular aortic repair and open aneurysmal sac revision. The pati...

    journal_title：Journal of vascular surgery

    pub_type：

    doi：10.1016/j.jvs.2018.09.038

    authors： Soler RJ,Fabre D,Watkins AC,Fadel E,Mercier O,Haulon S

    更新日期：2019-05-01 00:00:00

  • Outcomes of treatment with paclitaxel-coated devices for peripheral arterial disease.

    abstract：OBJECTIVE:The treatment of femoropopliteal peripheral artery disease (PAD) using paclitaxel-coated devices (PCDs) has been shown to improve patency in several randomized trials. However, a recent meta-analysis of trial data suggested an increased risk of mortality with PCD usage. Although subsequent studies have found ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2020.08.146

    authors： Kim TI,Kiwan G,Mohamedali A,Zhang Y,Mena-Hurtado C,Mojibian H,Guzman RJ,Ochoa Chaar CI

    更新日期：2020-10-07 00:00:00

  • Lymphorrhea responds to negative pressure wound therapy.

    abstract：:Lymphoceles and lymph fistulas are common complications of femoral exposure for vascular procedures. Three patients who required readmission after their vascular interventions were treated with negative pressure wound therapy. Once adequate control of the drainage was obtained, the patients were discharged home with a...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2006.10.043

    authors： Abai B,Zickler RW,Pappas PJ,Lal BK,Padberg FT Jr

    更新日期：2007-03-01 00:00:00

  • Endovascular treatment of thoracoabdominal aortic aneurysms.

    abstract：BACKGROUND:Development in endograft design has extended endovascular treatment to include thoracoabdominal aortic aneurysms (TAAA). We report our experience using fenestrated and branched endografts in the management of TAAA. METHODS:We analyzed a cohort of consecutive patients treated electively for TAAA using endova...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2012.01.008

    authors： Guillou M,Bianchini A,Sobocinski J,Maurel B,D'elia P,Tyrrell M,Azzaoui R,Haulon S

    更新日期：2012-07-01 00:00:00

  • Late patency of reconstructed visceral arteries after open repair of thoracoabdominal aortic aneurysm.

    abstract：BACKGROUND:In the era of rising endovascular treatment of thoracoabdominal aortic aneurysms (TAAAs), the analysis of visceral vessel (VV) patency after open surgical repair is crucial to provide a future benchmark between these different approaches. This study reports the late outcomes of a single-center experience wit...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2017.08.067

    authors： Kahlberg A,Ferrante AMR,Miloro R,Mascia D,Bertoglio L,Baccellieri D,Melissano G,Chiesa R

    更新日期：2018-04-01 00:00:00

  • Pathologic characteristics of recurrent carotid artery stenosis.

    abstract：:Recurrent carotid stenosis occurs randomly in approximately 10% of patients undergoing endarterectomy. Previous studies have described several histologic features but have failed to clearly elucidate the pathogenesis of this disorder. To improve our understanding of this disease, we reviewed pathologic lesions from 20...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1067/mva.1987.avs0050280

    authors： Schwarcz TH,Yates GN,Ghobrial M,Baker WH

    更新日期：1987-02-01 00:00:00

  • Duplex imaging findings predict stenosis after carotid endarterectomy.

    abstract：PURPOSE:This study was performed to determine whether early duplex findings predicted restenosis after carotid endarterectomy. METHODS:One hundred ninety-two symptomatic patients who underwent carotid endarterectomy were studied with color duplex imaging at 1 day and 1 week after surgery to identify minor residual dis...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(97)70145-9

    authors： Golledge J,Cuming R,Ellis M,Davies AH,Greenhalgh RM

    更新日期：1997-07-01 00:00:00

  • Functional outcome after surgical treatment for intermittent claudication.

    abstract：PURPOSE:Although patency data for lower extremity bypass grafts are readily available, few reports have focused on patients' satisfaction after surgical reconstruction for claudication. We reviewed our experience with surgical treatment for claudication, focusing on late outcome from the patients' perspective to furthe...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(96)70146-5

    authors： Zannetti S,L'Italien GJ,Cambria RP

    更新日期：1996-07-01 00:00:00

  • Ultrasound determination of total arterial wall thickness.

    abstract：PURPOSE:Ultrasonic measurement techniques for determining intima-media thickness and total arterial wall thickness have been described. The intima-media thickness measurements are currently in use in large epidemiologic trials. Intima-media thickness does not evaluate extramedial atherosclerotic change and so may not f...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/s0741-5214(94)70051-6

    authors： Hodges TC,Detmer PR,Dawson DL,Bergelin RO,Beach KW,Hatsukami TS,Zierler BK,Isaacson JA,Strandness DE Jr

    更新日期：1994-04-01 00:00:00

  • Fenestrated or branched endovascular aortic repair for postdissection thoracoabdominal aortic aneurysm.

    abstract：OBJECTIVE:Fenestrated or branched endovascular aortic repair (FB-EVAR) usually represents the last stage in endovascular treatment of postdissection aneurysm after thoracic endograft coverage of entry tear and false lumen embolization. METHODS:The study was a retrospective analysis of all patients with postdissection ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2018.10.117

    authors： Law Y,Tsilimparis N,Rohlffs F,Makaloski V,Behrendt CA,Heidemann F,Wipper SH,Debus ES,Kölbel T

    更新日期：2019-08-01 00:00:00

  • Surgical revascularization versus thrombolysis for nonembolic lower extremity native artery occlusions: results of a prospective randomized trial. The STILE Investigators. Surgery versus Thrombolysis for Ischemia of the Lower Extremity.

    abstract：PURPOSE:Early results of a prospective study that compared surgical revascularization and thrombolysis for lower extremity arterial and graft occlusions have been published. This report details the final results in patients who have native artery occlusions. METHODS:Two hundred thirty-seven patients who had lower extr...

    journal_title：Journal of vascular surgery

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0741-5214(96)70067-8

    authors： Weaver FA,Comerota AJ,Youngblood M,Froehlich J,Hosking JD,Papanicolaou G

    更新日期：1996-10-01 00:00:00

  • Training with simulation improves residents' endovascular procedure skills.

    abstract：BACKGROUND:Endovascular procedure simulators are now commercially available and in use for physician training. The purpose of this study was to evaluate the role of simulation-based training in vascular surgery residencies. METHODS:Residents from vascular surgery programs in a five-state area were invited to participa...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2006.09.003

    authors： Dawson DL,Meyer J,Lee ES,Pevec WC

    更新日期：2007-01-01 00:00:00

  • Characteristics that define high risk in carotid endarterectomy from the Vascular Study Group of New England.

    abstract：OBJECTIVE:The Stenting with Angioplasty and Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) trial compared carotid endarterectomy (CEA) to carotid artery stenting (CAS) among high-risk patients using a model of risk that has not been validated by previous publications. The objective of our study was t...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2015.04.398

    authors： Gates L,Botta R,Schlosser F,Goodney P,Fokkema M,Schermerhorn M,Sarac T,Indes J

    更新日期：2015-10-01 00:00:00

  • Distal internal carotid exposure: a simplified technique for temporary mandibular subluxation.

    abstract：:Distal internal carotid artery exposure can be technically demanding even for experienced vascular surgeons. Although a variety of techniques have been described to facilitate such exposure, temporary mandibular subluxation has emerged as the simplest and least debilitating approach. Current techniques for maintaining...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：

    authors： Dossa C,Shepard AD,Wolford DG,Reddy DJ,Ernst CB

    更新日期：1990-09-01 00:00:00

  • Liquid sclerotherapy for posttraumatic arteriovenous fistula of the radialis indicis artery.

    abstract：:We report the case of a 40-year-old woman with posttraumatic arteriovenous fistula of the right radialis indicis artery. The patient was admitted because a pulsatile lesion appeared on her hand after blunt trauma. Liquid sclerotherapy using 3% polidocanol in combination with distal protection using the rubber band tec...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2010.05.092

    authors： Katada Y,Ouchi K,Wakita T,Nozaki M

    更新日期：2010-11-01 00:00:00

  • Selective surgical therapy of the Budd-Chiari syndrome provides superior survivor rates than conservative medical management.

    abstract：:The Budd-Chiari syndrome is an unusual form of portal hypertension caused by hepatic vein occlusion, which results in centrilobular congestion and necrosis. Its overall mortality rate exceeds 50% at 2 years, and optimal treatment remains controversial. To determine optimal therapy on the basis of clinical and angiogra...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：

    authors： Ahn SS,Yellin A,Sheng FC,Colonna JO,Goldstein LI,Busuttil RW

    更新日期：1987-01-01 00:00:00

  • Occult antithrombin III deficiency: a potentially lethal complication of the postphlebitic limb.

    abstract：:Chronic venous insufficiency is a frequent sequel to lower extremity venous thrombosis. A relatively uncommon, but potentially lethal, cause of the thrombosis is congenital antithrombin III deficiency. Recognition and treatment of this occult deficiency is critical. The following report describes a family treated by t...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1067/mva.1990.17918

    authors： Phifer TJ,Mills GM

    更新日期：1990-04-01 00:00:00

  • Demonstration of cystic adventitial disease by intravascular ultrasound imaging.

    abstract：:In a 34-year-old woman with intermittent calf claudication, cystic adventitial disease of the popliteal artery was demonstrated by intravascular ultrasound imaging. Multiple intramural cystic masses were seen to be compressing the arterial lumen. The diagnoses of cystic adventitial disease was confirmed by surgery. In...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章,评审

    doi：10.1016/s0741-5214(96)80023-1

    authors： Koppensteiner R,Katzenschlager R,Ahmadi A,Staudacher M,Horvat R,Polterauer P,Ehringer H

    更新日期：1996-03-01 00:00:00

  • Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model.

    abstract：BACKGROUND:Compared with angiogenesis, arteriogenesis is a distinct process based on the remodeling and maturation of pre-existing arterioles into large conductance arteries. Therapeutic angiogenesis has been proposed as a potential treatment for ischemic atherosclerotic diseases. Since a variety of angiogenic factors ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2008.11.004

    authors： Katsanos K,Karnabatidis D,Diamantopoulos A,Kagadis GC,Ravazoula P,Nikiforidis GC,Siablis D,Tsopanoglou NE

    更新日期：2009-04-01 00:00:00

  • Coil embolization of persistent false lumen after stent graft repair of type B aortic dissection.

    abstract：:Patent false lumen after endovascular stent graft treatment of type B aortic dissection is a predictor for late death and retreatment. Between June 2008 and March 2010, five men with patent false lumen, due to a type B dissection previously treated with thoracic stent graft, underwent endovascular coiling treatment. W...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2010.11.110

    authors： Norberto EM,Gutiérrez VM,Taylor J,Vaquero C

    更新日期：2011-07-01 00:00:00

  • Trends and outcomes in endovascular and open surgical treatment of visceral aneurysms.

    abstract：OBJECTIVE:Visceral artery aneurysms (VAAs) are rare but often repaired because of dire consequences of rupture. This is a population-based evaluation of chronologic trends in management, risk factors, and outcomes of endovascular and open therapy. METHODS:The 2003 to 2013 Agency for Healthcare Research and Quality (AH...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2017.02.036

    authors： Chin JA,Heib A,Ochoa Chaar CI,Cardella JA,Orion KC,Sarac TP

    更新日期：2017-07-01 00:00:00

  • A novel approach for hybrid repair of type B aortic dissection associated with coarctation of the aorta.

    abstract：:We report the case of an acute type B aortic dissection in association with an unknown isthmic coarctation in a 53-year-old man. An intimal tear was located just distal to the coarctation, and the intimal flap extended to the level of the renal arteries. Hybrid repair was performed successfully 4 months later, without...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2013.05.089

    authors： Li Y,Fan Z,Huang L,Xue Y,Sun L

    更新日期：2014-05-01 00:00:00

  • Heparin-platelet factor 4 antibodies are frequent after vascular surgery but are not a frequent cause of graft thrombosis or thrombocytopenia.

    abstract：OBJECTIVE:Approximately 10% of infrainguinal bypass surgeries are complicated by early conduit failure. The cause is unclear in most cases. A prospective study was conducted to monitor the development and function of platelet factor 4 (PF4)/heparin antibodies after infrainguinal bypass procedures and to evaluate their ...

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2008.03.028

    authors： Alexy T,Tucker S,Boyle S,Rowe VL,Weaver FA,Liebman HA

    更新日期：2008-08-01 00:00:00

  • Percutaneous radiofrequency ablation: a novel treatment of facial venous malformation.

    abstract：:We performed radiofrequency ablation to treat a symptomatic facial venous malformation of a 24-year-old woman under ultrasound scan-guidance. The 20.25-cm sized original facial venous malformation in her right cheek markedly reduced without any scar formation and was grossly not visible after 1 month of the procedure....

    journal_title：Journal of vascular surgery

    pub_type： 杂志文章

    doi：10.1016/j.jvs.2009.03.047

    authors： Kim AH,Ko HK,Won JY,Lee DY

    更新日期：2009-08-01 00:00:00