Abstract:
:1. The responses of rat isolated aortae to vasoconstrictor and vasodilator agents have been studied in 14-day streptozotocin-diabetic rats. The effects of treatment with the aldose reductase inhibitor, ponalrestat, on these responses have also been investigated. 2. Maximum contractile responses and aortic sensitivity to phenylephrine were significantly enhanced in 14-day diabetic aortae. 3. In contrast, endothelium-dependent relaxations to carbachol were depressed in diabetic rats, whilst endothelium-independent relaxations to forskolin and sodium nitroprusside were unchanged. 4. Pretreatment with ponalrestat (25 mg kg-1, daily) prevented both the enhanced maximum contractile responses to phenylephrine and the depressed endothelium-dependent relaxations to carbachol in aortae from 14-day diabetic rats. Ponalrestat however, had no effect on the reduced phenylephrine EC50 values observed in tissues from diabetic animals. 5. It is concluded that ponalrestat prevents the depression of endothelium-dependent aortic relaxations induced by diabetes of 14 days duration, suggesting that the polyol pathway is involved in these vascular changes. Ponalrestat does not prevent the increase in aortic sensitivity to alpha 1-adrenoceptor agonists.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Otter DJ,Chess-Williams Rdoi
10.1111/j.1476-5381.1994.tb17028.xsubject
Has Abstractpub_date
1994-10-01 00:00:00pages
576-80issue
2eissn
0007-1188issn
1476-5381journal_volume
113pub_type
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journal_title:British journal of pharmacology
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doi:10.1038/sj.bjp.0702517
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pub_type: 杂志文章
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journal_title:British journal of pharmacology
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更新日期:2020-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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更新日期:1999-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00