Aloe vera and the inflamed synovial pouch model.

Abstract:

:Administration of air under the skin produced a pouch wall that closely resembled a synovium in that the inner lining was made up of macrophages and fibroblasts. Administration of 1% carrageenan directly into the 7-day-old air pouch produced an inflammation characterized by an increased number of mast cells in pouch fluid as well as an increase in wall vascularity. A punch biopsy weight of the pouch wall did not reveal an increase in 1% carrageenan-treated animals. However, a 10% Aloe vera treatment of carrageenan-inflamed synovial pouches reduced the vascularity 50% and the number of mast cells in synovial fluid 48%. The pouch wall punch biopsy weight was increased by A. vera, which was verified by histologic examination of the inner synovial lining. Aloe vera stimulated the synovial-like membrane, as evidenced by an increased number of fibroblasts, suggesting that A. vera stimulated fibroblasts for growth and repair of the synovial model. The synovial air pouch can be used to study simultaneously the acute anti-inflammatory and fibroblast stimulating activities of A. vera.

journal_name

J Am Podiatr Med Assoc

authors

Davis RH,Stewart GJ,Bregman PJ

doi

10.7547/87507315-82-3-140

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

140-8

issue

3

eissn

8750-7315

issn

1930-8264

journal_volume

82

pub_type

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