Abstract:
:Statistical methods are available for performing a meta-analysis when the response variable of interest is the same in each study. Problems arise when studies exploring a common therapeutic question use different patient response types. This article presents statistical methods for combining studies which involve different classifications of response into ordered categories. The assumptions required for the stratified proportional odds model, on which the analysis is based, are discussed. The approach is illustrated using results from a series of studies investigating the prevention of gastrointestinal damage induced by non-steroidal anti-inflammatory drugs.
journal_name
Stat Medjournal_title
Statistics in medicineauthors
Whitehead A,Jones NMdoi
10.1002/sim.4780132313subject
Has Abstractpub_date
1994-12-15 00:00:00pages
2503-15issue
23-24eissn
0277-6715issn
1097-0258journal_volume
13pub_type
杂志文章abstract::A method for detecting deviations from the Loewe additive drug combination reference model for in vitro drug combination experimentation is described. It is often difficult to fit a response surface model to drug combination data, especially in situations where the experimental design contains a sparse set of combinat...
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