Abstract:
:The pleiotropic cytokines, interleukin (IL)-1 alpha, type I interferons and IL-6 also act on cells involved in antibody production. Somehow the immunologic tolerance to these cytokines is often spontaneously broken--even in healthy individuals. Thus, relatively high concentrations of high affinity IgG antibodies against IL-1 alpha and IL-6 frequently occur in the circulation of healthy adults. The autoantibodies specifically antagonize the respective cytokines in vitro. Thermodynamic estimations strongly suggest that autoimmunity can play a significant role in the regulation of certain cytokines. In the light of IL-6 autoantibodies the possible biological and clinical significance of cytokine autoimmunity is discussed.
journal_name
Leukemiajournal_title
Leukemiaauthors
Hansen MB,Svenson M,Diamant M,Abell K,Bendtzen Ksubject
Has Abstractpub_date
1995-07-01 00:00:00pages
1113-5issue
7eissn
0887-6924issn
1476-5551journal_volume
9pub_type
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