Abstract：
:As the mechanisms controlling the amount and timing of growth saltations are not well understood, the identification of physiologic coupling in weight and length growth are important for further understanding normal growth biology. Thirty-four healthy infants (13 males, 21 females) participated in a longitudinal growth study during the first year. Weekly weights and s.c. skinfolds (limb and trunk) were analyzed in a growth event-focused study. Coincident analysis tested the null hypothesis of chance concurrence between significant weight gain and saltatory length growth spurts. Logistic regression quantified this relationship and investigated the interaction between incremental weight gain and s.c. skinfolds on length growth spurts. The null hypothesis of random coincidence between weight gain and saltatory length growth was not supported. For girls, significant weight gain and length growth were coupled during the same week and length saltations were 42% more likely during the weeks of significant weight gain, with no interaction from s.c. skinfolds. For boys, length growth saltations were coupled to both previous and concomitant weight gain but were predicted only by previous weight gain, controlling for confounders. Boys were 68% more likely to grow in length the week following significant weight gain, and initial abdominal to suprailiac skinfold ratios conferred a 4-fold increased likelihood of length growth within the week, controlling for confounders. These data generate the hypothesis that a common growth signal cascade couples growth in weight and length/height with a time delay due to sex-specific biology, reflected in a s.c. fat fold interface.
journal_name
Pediatr Resjournal_title
Pediatric researchauthors
Lampl M,Thompson AL,Frongillo EAdoi
10.1203/01.pdr.0000184327.65102.a6subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1238-42issue
6eissn
0031-3998issn
1530-0447pii
58/6/1238journal_volume
58pub_type
杂志文章abstract：:The activity of lysozyme in saliva and serum was determined in 51 patients with cystic fibrosis. Measurements were made on two occasions at least 1 month apart and compared to those of 25 normal healthy individuals of the same ages, sex, and race. The mean serum lysozyme activity of normal individuals was 5.8 microgra...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198210000-00014
更新日期：1982-10-01 00:00:00
abstract：:To assess the National Institutes of Health extramural activity in the area of pediatric nephrology research, the rate of submission of grant applications to the National Institutes of Health and available indicators of the quality of these applications were analyzed. This was accomplished by utilizing the grant appli...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198511000-00001
更新日期：1985-11-01 00:00:00
abstract：:Human and ovine placental tissue homogenates were assayed for dipeptidase activity in vitro. Glycyl-L-leucine, L-leucyl glycine, glycyl-L-lysine, and L-lysyl glycine were hydrolyzed by placental homogenates. The pH optimum for the reaction was 8.0. The relationship between enzyme activity and concentration was linear ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198104000-00013
更新日期：1981-04-01 00:00:00
abstract：:Infants with sudden infant death syndrome have higher hypoxanthine (Hx) concentrations in their vitreous humor than infants with respiratory distress syndrome and other infant control populations. However, previous research on piglets and pigs applying continuous hypoxemia has not been able to reproduce the concentrat...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199312000-00013
更新日期：1993-12-01 00:00:00
abstract：:Ambient oxygen concentration and vascular endothelial growth factor (VEGF)-A are vital in lung development. Since hypoxia stimulates VEGF-A production and hyperoxia reduces it, we hypothesized that VEGF-A down-regulation by exposure of airways to hyperoxia may result in abnormal lung development. An established model ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/PDR.0b013e31815b4857
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Bradycardia and oxygen desaturation episodes are common among preterm very low birth weight (VLBW) infants in the Neonatal Intensive Care Unit (NICU), and their association with adverse outcomes such as bronchopulmonary dysplasia (BPD) is unclear. METHODS:For 502 VLBW infants we quantified bradycardias (HR ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0223-5
更新日期：2019-06-01 00:00:00
abstract：:Infection with human immunodeficiency virus (HIV) causes a progressive immunodeficiency, often manifested in adults by the development of infections with relatively rare, opportunistic organisms. However, in HIV-infected children, recurrent serious infections with common encapsulated bacteria, as well as recurrent min...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验,评审
doi：10.1203/00006450-199305001-00464
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND:Caffeine is widely used to manage apnea of prematurity, and reduces the incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor (TGF)-β signaling underlies arrested postnatal lung maturation in BPD. It is unclear whether caffeine impacts TGF-β signaling or postnatal lung develop...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2017.21
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Phytosterols in soybean oil (SO) lipids likely contribute to parenteral nutrition-associated liver disease (PNALD) in infants. No characterization of phytosterol metabolism has been done in infants receiving SO lipids. METHODS:In a prospective cohort study, 45 neonates (36 SO lipid vs. 9 control) underwent ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/pr.2015.78
更新日期：2015-08-01 00:00:00
abstract：:Chenodeoxycholic acid labeled with 2H in the 11 and positions was prepared by catalytic reduction of delta 11-12 unsaturated derivatives of cholic acid. To validate the use of this stable isotope for the determination of bile acid kinetics by isotope dilution, it was administered to seven normal male volunteers simult...
journal_title：Pediatric research
pub_type： 杂志文章
doi：
更新日期：1975-10-01 00:00:00
abstract：:The antiendotoxin effect of polymyxin B was investigated in experimentally induced septicemia in rabbits. The Pasteurella multocida organisms were sensitive to the antibacterial action of penicillin but not to polymyxin B. Animals pre-treated with polymyxin showed positive blood cultures and significantly reduced plas...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197901000-00011
更新日期：1979-01-01 00:00:00
abstract：:Simultaneous measurements of serum immunoreactive thyrocalcitonin (iTCT), immunoreactive parathyroid hormone (iPTH), calcium, inorganic phosphate, magnesium, and alkaline phosphatase were made in 37 normal children whose ages ranged from 6-12 years. Between the ages of 6 and 12 there is a statistically significant ris...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197702000-00006
更新日期：1977-02-01 00:00:00
abstract：:Intestinal absorption and its relationship to increased total body water was studied in seven infants with congenital heart disease receiving regular diuretics due to congestive heart failure. All infants and six age-matched healthy controls were studied for a 3-d period during which time all food intake was recorded,...
journal_title：Pediatric research
pub_type： 临床试验,杂志文章
doi：10.1203/00006450-199410000-00023
更新日期：1994-10-01 00:00:00
abstract：:The mitochondrial DNA (mtDNA) point mutation T8993G has been associated with maternally inherited Leigh syndrome (MILS) when very abundant (> 95%). MILS patients are usually severely affected and die in early infancy. In 1993, a novel T8993C point mutation was described in a juvenile form of Leigh syndrome (LS) charac...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199605000-00028
更新日期：1996-05-01 00:00:00
abstract：:Altered transfer of nutrients from mother to conceptus may be involved in the pathogenesis of the developmental disturbances in offspring of diabetic mothers. In our study, the embryonic uptake of a saturated (palmitic acid) and a nonsaturated (arachidonic acid) fatty acid was evaluated in a normal and a diabetes-like...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199108000-00005
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:Pulmonary hypertension (PH) in patients with bronchopulmonary dysplasia (BPD) results from vasoconstriction and/or vascular remodeling, which can be regulated by mitogen-activated protein kinases (MAPKs). MAPKs are deactivated by dual-specificity phosphatases (DUSPs). We hypothesized that single-nucleotide p...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-019-0502-9
更新日期：2020-01-01 00:00:00
abstract：:The ability of erythrocytes from newborn babies and adults to maintain reduced glutathione levels during oxidative stress was studied. In vitro incubation of erythrocytes with H2O2, with or without inactivation of catalase, caused a rapid depletion of reduced glutathione (GSH) and concomitant accumulation of oxidized ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199210000-00006
更新日期：1992-10-01 00:00:00
abstract：:Monocyte chemoattractant protein-1 (MCP-1), acting through its C-C chemokine receptor 2 (CCR-2), has important roles in inflammation, angiogenesis, and wound repair. The individual and combined effects of inhaled nitric oxide (NO) and hyperoxia on lung MCP-1 and CCR-2 in relation to lung leukocyte dynamics are unknown...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-200111000-00017
更新日期：2001-11-01 00:00:00
abstract：:Studies using stable isotopically labeled glucose and palmitate as precursors of pulmonary surfactant synthesis have demonstrated slow surfactant turnover in premature infants with respiratory distress syndrome (RDS). However, only limited data about surfactant turnover are available for term infants. Because acetate ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000075084.56255.E0
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Regular physical activity provides children with health and developmental benefits. This study investigated if active play and walking with the family dog was associated with better social-emotional development in young children. METHODS:We surveyed 1646 parents to ascertain if families with pre-schoolers o...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-020-1007-2
更新日期：2020-07-06 00:00:00
abstract：:Various assay methods for detection of thyroid hormones in human milk were evaluated in recovery and dilution experiments after which the concentrations of thyroxine (T4) and 3,5,3'-triiodothyronine (T3) were measured and compared with those in serum. The effect of breast feeding on pituitary thyroid function of norma...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198306000-00008
更新日期：1983-06-01 00:00:00
abstract：:To evaluate the response of the small intestinal mucosa to Saccharomyces boulardii (S.b.), a yeast widely used in some countries as an adjuvant drug with oral antimicrobial therapy, seven healthy adult volunteers were treated with high doses of lyophilized S.b. (250 mg four times per day) for 2 wk. A peroral jejunal s...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198602000-00020
更新日期：1986-02-01 00:00:00
abstract：BACKGROUND:Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METH...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1038/s41390-018-0009-9
更新日期：2018-07-01 00:00:00
abstract：:Malignant osteopetrosis is a fatal congenital bone disorder characterized by defective osteoclastic function. Death frequently occurs within the first decade of life. The precise molecular defect(s) that causes osteopetrosis is not known. The possibility that osteoclasts, like macrophages, are controlled by interactio...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199304000-00014
更新日期：1993-04-01 00:00:00
abstract：:Previously, we have reported marked pulmonary inflammation in infants who develop chronic lung disease of prematurity. We revisited these infants who did not have clinical or laboratory evidence of infection and searched for Ureaplasma urealyticum, group B streptococci, and other microbes by reverse transcription-PCR ...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/01.PDR.0000100757.38675.50
更新日期：2004-01-01 00:00:00
abstract：:Several markers of growth and biochemical development in the rat were studied after administration of prostacyclin (PGI2) and 16, 16-dimethyl prostaglandin E2 (16, 16DM PGE2). Intermittent administration of PGI2 for 3 days to 10- and 19-day-old animals, with subsequent sacrifice at 14 and 23 days, resulted in signific...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198307000-00004
更新日期：1983-07-01 00:00:00
abstract：:An Epstein-Barr virus-transformed B-cell line derived from a patient with severe combined immunodeficiency who died of a lymphoreticular malignancy has been characterized. The line derived from bone marrow cultures and designated DV-1 shows surface and cytoplasmic IgM and staining with fluorescent monoclonal antibodie...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-198704000-00003
更新日期：1987-04-01 00:00:00
abstract：:Young adult macrosomic offspring of streptozotocin-induced mildly hyperglycemic rats exhibit accelerated growth through the first 10 wk of age. At 10 wk, oral glucose loading resulted in elevated plasma insulin and glucose concentrations compared to controls. To assess the mechanism of the abnormal glucose tolerance i...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199107000-00008
更新日期：1991-07-01 00:00:00
abstract：:We studied the mechanisms by which C16:0 lysophosphatidylcholine (LPC) and albumin inhibit the surface activity of calf lung surfactant extract (CLSE) by using a pulsating bubble apparatus with a specialized hypophase exchange system, plus adsorption and Wilhelmy balance measurements. In the absence of inhibitors, CLS...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-199907000-00015
更新日期：1999-07-01 00:00:00
abstract：:The hypoxanthine concentration in plasma was found to be a sensitive parameter of hypoxia of the fetus and the newborn infant. The plasma level of hypoxanthine in the umbilical cord in 29 newborn infants with normal delivery varied between 0 and 11.0 mumol/liter with a mean of 5.8 mumol/liter, SD 3.0 mumol/liter. Comp...
journal_title：Pediatric research
pub_type： 杂志文章
doi：10.1203/00006450-197504000-00002
更新日期：1975-04-01 00:00:00
