Patient with markedly elevated CA 19-9 not associated with malignancy.

Abstract:

:A 66-year-old white male presented with jaundice, pruritus, and a 30-pound weight loss over two months. Physical examination revealed scleral icterus. Laboratory evaluation revealed ALT 161 U/L, AST 290 U/L, alkaline phosphatase 2004 U/L, GGT 2,552 U/L, total bilirubin 10.2 mg/dL, and a carbohydrate antigen 19-9 (CA 19-9) level of 4,374 U/mL. Initial endoscopic retrograde cholangiopancreatography (ERCP) was unsuccessful due to ulceration in the duodenum healed with esomeprazole therapy. Subsequent ERCP showed a possible filling defect in the common bile duct treated with sphincterotomy and balloon sweeping of the common bile duct. Symptoms and jaundice resolved five months after initial presentation with normal labs and studies. While elevated CA 19-9 levels occur in most patients with carcinoma of the pancreas, it can also be elevated in patients with extrapancreatic malignancies and acute cholangitis. This case illustrates the fact that a markedly elevated CA 19-9 can be secondary to causes other than carcinoma.

journal_name

South Med J

journal_title

Southern medical journal

authors

Lowe D,Lee J,Schade R,Chaudhary A

doi

10.1097/01.smj.0000202695.97123.2b

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

306-8

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

99

pub_type

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