Assessment of bone marrow angiogenesis in patients with acute myeloid leukemia by using contrast-enhanced MR imaging with clinically approved iron oxides: initial experience.

Abstract:

PURPOSE:To prospectively assess bone marrow (BM) angiogenesis in patients with acute myeloid leukemia (AML) by using iron oxide-enhanced magnetic resonance (MR) imaging. MATERIALS AND METHODS:The study was institutional ethics committee approved. Informed signed consent was obtained from each study participant. The requirement for informed consent for use of data from a reference database was waived. Eleven patients (seven women, four men; mean age, 53 years+/-4.40 [standard deviation]) with an initial diagnosis of AML were enrolled in the study and underwent T2*-weighted two-echo echo-planar MR imaging of the pelvis before and after intravenous injection of a clinically approved iron oxide blood-pool contrast agent. Six healthy control subjects (one woman, five men; mean age, 35 years+/-2.31) were examined with the same MR protocol. The iron oxide-induced change in R2* relaxation rate (DeltaR2*) was calculated, and the vascular volume fraction (VVF) of the BM was derived by dividing the DeltaR2* of the BM by the DeltaR2* of the muscle. Parametric DeltaR2* maps were calculated to visualize vessel distribution. Patients underwent BM biopsy for correlative determination of microvessel density (MVD) and vascular endothelial growth factor (VEGF). Differences in DeltaR2*, VVF, VEGF, and MVD were compared by using the Wilcoxon rank sum test. RESULTS:DeltaR2* maps showed prominent areas of highly vascularized BM in the patients with AML, whereas the control subjects had moderately vascularized BM with homogeneous vessel distribution. Quantitative analysis revealed VVF values to be significantly higher in patients with AML than in control subjects: The mean VVF in the pelvis was 9.18%+/-1.54 for patients versus 3.91%+/-0.61 for control subjects (P=.010). In accordance with MR results, MVD (P=.009) and VEGF expression (P=.017) were significantly elevated in the AML group compared with values in the control group. CONCLUSION:Iron oxide-enhanced MR imaging enables assessment of BM angiogenesis in patients with AML.

journal_name

Radiology

journal_title

Radiology

authors

Matuszewski L,Persigehl T,Wall A,Meier N,Bieker R,Kooijman H,Tombach B,Mesters R,Berdel WE,Heindel W,Bremer C

doi

10.1148/radiol.2421051355

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

217-24

issue

1

eissn

0033-8419

issn

1527-1315

pii

2421051355

journal_volume

242

pub_type

杂志文章
  • Noninvasive assessment of acute ureteral obstruction with diffusion-weighted MR imaging: a prospective study.

    abstract:PURPOSE:To prospectively assess the potential of noninvasive diffusion-weighted magnetic resonance (MR) imaging to depict changes in microperfusion and diffusion in patients with acute unilateral ureteral obstruction. MATERIALS AND METHODS:The local ethics committee approved the study protocol. Informed consent was ob...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2523082090

    authors: Thoeny HC,Binser T,Roth B,Kessler TM,Vermathen P

    更新日期:2009-09-01 00:00:00

  • Lupus nephritis: predictive value of conventional and Doppler US and comparison with serologic and biopsy parameters.

    abstract:PURPOSE:To compare conventional and Doppler ultrasound (US) with clinical and biopsy parameters used to assess disease activity and outcome in lupus nephritis and to assess the predictive value of US. MATERIALS AND METHODS:Thirty-four patients with lupus nephritis prospectively underwent laboratory and US analysis at ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.203.1.9122420

    authors: Platt JF,Rubin JM,Ellis JH

    更新日期:1997-04-01 00:00:00

  • Subcortical damage and cortical functional changes in men and women with Fabry disease: a multifaceted MR study.

    abstract:PURPOSE:To prospectively compare brain magnetic resonance (MR) imaging and hydrogen 1 (1H) MR spectroscopy findings and to use functional MR imaging to explore the patterns of brain activation in men and women with Fabry disease (FD). MATERIALS AND METHODS:Eight men and eight women with FD (mean age, 38.8 years +/- 13...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2412051122

    authors: Gavazzi C,Borsini W,Guerrini L,Della Nave R,Rocca MA,Tessa C,Buchner S,Belli G,Filippi M,Villari N,Mascalchi M

    更新日期:2006-11-01 00:00:00

  • Clinical digital breast tomosynthesis system: dosimetric characterization.

    abstract:PURPOSE:To comprehensively characterize the dosimetric properties of a clinical digital breast tomosynthesis (DBT) system for the acquisition of mammographic and tomosynthesis images. MATERIALS AND METHODS:Compressible water-oil mixture phantoms were created and imaged by using the automatic exposure control (AEC) of ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.11111789

    authors: Feng SS,Sechopoulos I

    更新日期:2012-04-01 00:00:00

  • Intraluminal colon pressure dynamics with Valsalva maneuver during air enema study.

    abstract:PURPOSE:To determine the effects of the Valsalva maneuver on intraluminal colon pressure during air enema studies. MATERIALS AND METHODS:Air enema studies were performed in four adult volunteers, and intraluminal colon pressure measurements were recorded with a high-speed electronic strip chart and aneroid gauge metho...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.202.3.9051040

    authors: Bramson RT,Shiels WE 2nd,Eskey CJ,Hu SY

    更新日期:1997-03-01 00:00:00

  • Kidney length correlated with age: normal values in children.

    abstract::Normal kidney length was measured on the excretory urogram in 262 children 0 to 14.5 years of age (422 kidneys). While mean values were similar to those in the literature, the standard deviation (0.785 cm) was much lower than that reported previously. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.150.3.6695070

    authors: Currarino G,Williams B,Dana K

    更新日期:1984-03-01 00:00:00

  • Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal-tissue microcirculation.

    abstract::In tumor radiobiology, the hypoxic cell has become especially important because of recent evidence of acute hypoxic regions within experimental tumors. The impact of hyperthermia on the development of acute hypoxia is discussed. Two experiments for studying hyperthermia and hypoxia in tumors are presented. Knowledge o...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.137.3.7003650

    authors: Dewhirst MW,Ozimek EJ,Gross J,Cetas TC

    更新日期:1980-12-01 00:00:00

  • Angiography of angiomatous lymphoid hamartoma (Castleman tumor) and a suggested pathogenesis.

    abstract::The histological nature and angiographic characteristics of two cases of Castleman tumor support the concept that these tumors are hamartomatous. On angiography, both tumors exhibited a dense and homogeneous blush in the later phase. In one, in the mediastinum, hypertrophied branches of the bronchial artery gave rise ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/130.2.311

    authors: Tuttle RJ,Shier KJ

    更新日期:1979-02-01 00:00:00

  • Porous-coated anatomic total hip prostheses: radiographic analysis and clinical correlation.

    abstract::The radiographic changes of 46 bone-ingrowth, porous-coated anatomic total hip prostheses were reviewed and compared to the clinical outcome. The average postoperative follow-up was 32 months. The radiographic features that were assessed included subsidence; periprosthetic lucencies; periosteal, endosteal, and heterot...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.174.3.2305070

    authors: Kattapuram SV,Lodwick GS,Chandler H,Khurana JS,Ehara S,Rosenthal DI

    更新日期:1990-03-01 00:00:00

  • A prospective study of computed tomography and ultrasound in the detection and staging of pelvic masses.

    abstract::Findings from computed tomography (CT) and ultrasound (US) examinations of 74 patients who were clinically thought to have pelvic masses and of 110 patients who had possible recurrence of pelvic tumors were analyzed. There was no significant difference in the ability of the two modalities to identify masses or to pred...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.146.2.6849090

    authors: Sanders RC,McNeil BJ,Finberg HJ,Hessel SJ,Siegelman SS,Adams DF,Alderson PO,Abrams HL

    更新日期:1983-02-01 00:00:00

  • The accordion sign at CT: a nonspecific finding in patients with colonic edema.

    abstract:PURPOSE:To determine whether the "accordion sign" is a specific computed tomographic (CT) sign of Clostridium difficile colitis. MATERIALS AND METHODS:Fifty-seven patients with CT evidence of severe colitis, as judged by colonic wall thickening, an abnormal haustral pattern, the target sign, and stranding of the peric...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.211.3.r99jn32743

    authors: Macari M,Balthazar EJ,Megibow AJ

    更新日期:1999-06-01 00:00:00

  • Suspected pulmonary embolism: enhancement of pulmonary arteries at deep-inspiration CT angiography--influence of patent foramen ovale and atrial-septal defect.

    abstract:PURPOSE:To investigate if abnormal early contrast enhancement of the aorta and decreased attenuation of pulmonary arteries at deep-inspiration spiral computed tomographic (CT) angiography might be caused by a patent foramen ovale (PFO). MATERIALS AND METHODS:Two hundred forty-four spiral CT angiographic images of the ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2263012200

    authors: Henk CB,Grampp S,Linnau KF,Thurnher MM,Czerny C,Herold CJ,Mostbeck GH

    更新日期:2003-03-01 00:00:00

  • Beam anomaly for a cobalt-60 teletherapy machine.

    abstract::A beam anomaly due to trimmer bars for a cobalt teletherapy machine and the possible consequences in clinical work are reported. ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/128.3.807a

    authors: Aoki CT

    更新日期:1978-09-01 00:00:00

  • CT bronchoscopy: optimization of imaging parameters.

    abstract::The authors evaluated the relative importance of the following scanning parameters at computed tomographic bronchoscopy in an anesthetized adult sheep's thorax: section thickness (2, 4, 8 mm), pitch (1.0, 1.5, 2.0), milliampere setting (100, 175, 250 mA), and overlap of reconstructed sections (0%, 25%, 50%, 75%). Five...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.209.3.9844690

    authors: Hopper KD,Iyriboz TA,Mahraj RP,Wise SW,Kasales CJ,TenHave TR,Wilson RP,Weaver JS

    更新日期:1998-12-01 00:00:00

  • Intussusception: hydrostatic pressure equivalents for barium and meglumine sodium diatrizoate.

    abstract::The pressures generated by a barium suspension and various solutions of meglumine sodium diatrizoate in water were measured with a manometer. A pressure of 120 mm Hg was produced by a 3.5-foot (105-cm) column of 60% wt/vol barium and a 5-foot (150-cm) column of either a 1:3 or 1:4 solution of meglumine sodium diatrizo...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.175.1.2315470

    authors: Kuta AJ,Benator RM

    更新日期:1990-04-01 00:00:00

  • Appendicitis: efficacy of color Doppler sonography.

    abstract:PURPOSE:To determine whether the addition of color Doppler ultrasonography (US) to gray-scale US can help diagnose appendicitis in children. MATERIALS AND METHODS:One hundred children with suspected appendicitis were evaluated with gray-scale and color Doppler US scanning. Color Doppler US scans were considered positi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.191.2.8153340

    authors: Quillin SP,Siegel MJ

    更新日期:1994-05-01 00:00:00

  • Identifying minimally acceptable interpretive performance criteria for screening mammography.

    abstract:PURPOSE:To develop criteria to identify thresholds for minimally acceptable physician performance in interpreting screening mammography studies and to profile the impact that implementing these criteria may have on the practice of radiology in the United States. MATERIALS AND METHODS:In an institutional review board-a...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.10091636

    authors: Carney PA,Sickles EA,Monsees BS,Bassett LW,Brenner RJ,Feig SA,Smith RA,Rosenberg RD,Bogart TA,Browning S,Barry JW,Kelly MM,Tran KA,Miglioretti DL

    更新日期:2010-05-01 00:00:00

  • Endothelial cell biology.

    abstract::The endothelium is not a passive blood-compatible lining for the containment of blood cells and plasma, but rather it is a metabolically active tissue that subserves a wide range of functions relating to vascular homeostasis. This article reviews the current understanding of endothelial cell biology in terms of the mo...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.179.1.2006310

    authors: Pearson JD

    更新日期:1991-04-01 00:00:00

  • Endometrial evaluation with transvaginal US and hysterosonography in asymptomatic postmenopausal women with breast cancer receiving tamoxifen.

    abstract:PURPOSE:To determine performance characteristics of transvaginal ultrasonography (US) and hysterosonography for diagnosing endometrial abnormality in asymptomatic postmenopausal women with breast cancer receiving tamoxifen. MATERIALS AND METHODS:The authors prospectively examined 138 women receiving tamoxifen by using...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2203010011

    authors: Fong K,Kung R,Lytwyn A,Trudeau M,Chapman W,Nugent P,Glanc P,Manchul L,Szabunio D,Myhr T

    更新日期:2001-09-01 00:00:00

  • False-Positive Measurement at 2-Hydroxyglutarate MR Spectroscopy in Isocitrate Dehydrogenase Wild-Type Glioblastoma: A Multifactorial Analysis.

    abstract::Background Isocitrate dehydrogenase (IDH) mutation has become one of the most important prognostic biomarkers in glioma management. Measurement of 2-hydroxyglutarate (2HG) with MR spectroscopy has shown high pooled sensitivity, although false-positive results with MR spectroscopy have been reported. Purpose To investi...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2019182200

    authors: Suh CH,Kim HS,Paik W,Choi C,Ryu KH,Kim D,Woo DC,Park JE,Jung SC,Choi CG,Kim SJ

    更新日期:2019-06-01 00:00:00

  • Free-breathing black-blood coronary MR angiography: initial results.

    abstract::The authors developed a free-breathing black-blood coronary magnetic resonance (MR) angiographic technique with a potential for exclusive visualization of the coronary blood pool. Results with the MR angiographic technique were evaluated in eight healthy subjects and four patients with coronary disease identified at c...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.219.1.r01mr07278

    authors: Stuber M,Botnar RM,Kissinger KV,Manning WJ

    更新日期:2001-04-01 00:00:00

  • Subcortical alterations in tissue microstructure adjacent to focal cortical dysplasia: detection at diffusion-tensor MR imaging by using magnetoencephalographic dipole cluster localization.

    abstract:PURPOSE:To determine whether changes at diffusion-tensor magnetic resonance (MR) imaging were present in children with intractable epilepsy and focal cortical dysplasia (FCD) in (a) subcortical white matter subjacent to MR imaging-visible areas of FCD, (b) subcortical white matter beyond the MR imaging-visible abnormal...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2511081092

    authors: Widjaja E,Zarei Mahmoodabadi S,Otsubo H,Snead OC,Holowka S,Bells S,Raybaud C

    更新日期:2009-04-01 00:00:00

  • Two-phase helical CT for pancreatic tumors: pancreatic versus hepatic phase enhancement of tumor, pancreas, and vascular structures.

    abstract:PURPOSE:To quantitatively evaluate and validate a two-phase helical computed tomographic (CT) protocol for evaluation of pancreatic tumors. MATERIALS AND METHODS:Twenty-seven patients with pathologically proved pancreatic adenocarcinomas prospectively underwent two-phase CT examination with helical acquisition during ...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.199.3.8637990

    authors: Lu DS,Vedantham S,Krasny RM,Kadell B,Berger WL,Reber HA

    更新日期:1996-06-01 00:00:00

  • Core-needle and surgical breast biopsy: comparison of three methods of assessing cost.

    abstract:PURPOSE:To compare and evaluate the measures of costs for core-needle and surgical breast biopsies. MATERIALS AND METHODS:Three measures of costs were evaluated: (a) input resources, (b) actual payments, and (c) billed charges. A combination of methods were used for data collection from 10 sites enrolled in a large-sc...

    journal_title:Radiology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1148/radiology.212.1.r99jl46181

    authors: Burkhardt JH,Sunshine JH

    更新日期:1999-07-01 00:00:00

  • The Kimray-Greenfield filter: evaluation by duplex real-time/pulsed Doppler ultrasound.

    abstract::The Kimray-Greenfield filter is a wire cage which is inserted into the inferior vena cava (IVC) to prevent thrombi originating in pelvic and leg veins from embolizing to the lungs. Duplex real-time/pulsed Doppler ultrasound was used to evaluate placement and function in 38 patients (46 examinations). Real-time examina...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.148.1.6856840

    authors: Pasto ME,Kurtz AB,Jarrell BE,Dubbins PA,Rifkin MD,Cole-Beuglet C,Baltarowich O,Goldberg BB

    更新日期:1983-07-01 00:00:00

  • Economic and cost-effectiveness investigations of radiologic practices.

    abstract::Economic evaluations provide scientific data regarding the cost implications of radiologic practices and, most important, which strategies for patient care yield the best outcomes for the least cost. Although this article is meant to enrich understanding of cost-effectiveness studies, it cannot be regarded as a comple...

    journal_title:Radiology

    pub_type: 杂志文章,评审

    doi:10.1148/radiology.192.1.8208920

    authors: Powe NR

    更新日期:1994-07-01 00:00:00

  • Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience.

    abstract:PURPOSE:To prospectively assess the oxygenation state of renal transplants and determine the feasibility of using blood oxygen level-dependent (BOLD) magnetic resonance (MR) imaging to differentiate between acute tubular necrosis (ATN), acute rejection, and normal function. MATERIALS AND METHODS:This HIPAA-compliant s...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2363041080

    authors: Sadowski EA,Fain SB,Alford SK,Korosec FR,Fine J,Muehrer R,Djamali A,Hofmann RM,Becker BN,Grist TM

    更新日期:2005-09-01 00:00:00

  • Adaptive technique for three-dimensional MR imaging of moving structures.

    abstract::The authors describe an adaptive motion correction method for three-dimensional magnetic resonance (MR) imaging. Three-dimensional imaging offers many advantages over two-dimensional multisection imaging but is susceptible to image corruption due to motion. Thus, it has been of limited use in the imaging of mobile str...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.177.1.2399320

    authors: Korin HW,Felmlee JP,Ehman RL,Riederer SJ

    更新日期:1990-10-01 00:00:00

  • Noxious somatosensory stimulation affects the default mode of brain function: evidence from functional MR imaging.

    abstract:PURPOSE:To investigate whether default mode network (DMN) spatial properties can be directly affected by pain, with a comparison of painful and nonpainful conditions. MATERIALS AND METHODS:The authors performed a functional magnetic resonance (MR) imaging study, approved by the local institutional ethics committee, in...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiol.2533090602

    authors: Mantini D,Caulo M,Ferretti A,Romani GL,Tartaro A

    更新日期:2009-12-01 00:00:00

  • Treated thymic lymphoma: comparison of MR imaging with CT.

    abstract:PURPOSE:To determine the appearance of treated thymic lymphoma at magnetic resonance (MR) imaging and to compare the results with findings from posttherapy computed tomography (CT) and clinical outcome. MATERIALS AND METHODS:MR images and CT scans in 25 patients with thymic lymphoma were reviewed. Dimensions of residu...

    journal_title:Radiology

    pub_type: 杂志文章

    doi:10.1148/radiology.203.2.9114090

    authors: Spiers AS,Husband JE,MacVicar AD

    更新日期:1997-05-01 00:00:00