Abstract:
:The binding interactions of some aryl carboxylic acid derivatives have been examined by circular dichroism and fluorescence spectroscopy. With specific probes, we have shown that the seven ligands under study bind primarily to the benzodiazepine site on HSA. Their association constants are in the range of 10(5)-10(6) M-1 as found by spectropolarimetric titration, and appear to be closely related to some chemical features. It is concluded that the binding is enhanced by the lengthening of the carbon chain substituent with a terminating carboxyl moiety and by halogen substitution in the aromatic rings. It is further shown that hydrophilic substitutions such as hydroxyl or ketone groups in the carbon chain substituent will decrease the binding.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Urien S,D'Athis P,Tillement JPdoi
10.1016/0006-2952(84)90668-3subject
Has Abstractpub_date
1984-07-15 00:00:00pages
2283-9issue
14eissn
0006-2952issn
1873-2968pii
0006-2952(84)90668-3journal_volume
33pub_type
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pub_type: 杂志文章
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doi:10.1016/0006-2952(84)90483-0
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1987-03-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1983-07-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:1988-12-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(93)90147-o
更新日期:1993-02-09 00:00:00