The effect of multiple doses of peginterferon alfa-2b on the steady-state pharmacokinetics of methadone in patients with chronic hepatitis C undergoing methadone maintenance therapy.

abstract：:The objective of this study was to determine the effects of double-strength grapefruit juice on gastric pH and systemic bioavailability of indinavir in HIV-infected subjects receiving indinavir. Fourteen HIV-infected subjects took 800 mg of indinavir with 6 ounces (180 ml) of water or double-strength grapefruit juice....

journal_title：Journal of clinical pharmacology

authors： Shelton MJ,Wynn HE,Hewitt RG,DiFrancesco R

更新日期：2001-04-01 00:00:00

abstract：:Numerous physiologic variations, including urinary protein excretion, low serum albumin concentrations, and reductions in kidney function (clearance), exist in patients with glomerulonephritis. These factors could alter the disposition of numerous drugs. The purpose of the current article was to review the influence o...

journal_title：Journal of clinical pharmacology

authors： Joy MS

更新日期：2012-01-01 00:00:00

abstract：:A treatment gap exists for pediatric patients with renal impairment. Alterations in renal clearance and metabolism of drugs render standard dosage regimens inappropriate and may lead to drug toxicity, but these studies are not routinely conducted during drug development. The objective of this study was to examine the ...

journal_title：Journal of clinical pharmacology

authors： Al-Khouja A,Park K,Anderson DJC,Young C,Wang J,Huang SM,Khurana M,Burckart GJ

更新日期：2020-12-01 00:00:00

abstract：:This open-label study evaluated apixaban pharmacokinetics, pharmacodynamics, and safety in subjects with mild, moderate, or severe renal impairment and in healthy subjects following a single 10-mg oral dose. The primary analysis determined the relationship between apixaban AUC∞ and 24-hour creatinine clearance (CLcr )...

journal_title：Journal of clinical pharmacology

authors： Chang M,Yu Z,Shenker A,Wang J,Pursley J,Byon W,Boyd RA,LaCreta F,Frost CE

更新日期：2016-05-01 00:00:00

abstract：:The effect of 6% hydroxyethyl starch (hetastarch) and 5% human serum albumin (albumin) infusion on coagulation in 12 patients with septic shock was evaluated. Patients were randomly assigned to receive either albumin (N = 6) or hetastarch (N = 6) infusion over a 24-hour study interval. The prothrombin time (PT), parti...

journal_title：Journal of clinical pharmacology

authors： Falk JL,Rackow EC,Astiz ME,Weil MH

更新日期：1988-05-01 00:00:00

abstract：:The increased availability of chemical intermediates and automated instrumentation has resulted in expanded use of stable isotopes for bioavailability and bioequivalence studies in recent years. Initially, stable isotopes were confined to the labeling of mass internal standard compounds for gas chromatography/mass spe...

journal_title：Journal of clinical pharmacology

authors： Wolen RL

更新日期：1986-07-01 00:00:00

abstract：:A four-week comparison of protriptyline 10 mg three times a day and perphenazine 2 mg three times a day, alone and in combination, and a placebo in a group of nonpsychotic depressed outpatients showed no significant differences among any of the treatment groups after both two and four weeks, and a slight trend in favo...

journal_title：Journal of clinical pharmacology

authors： Weinstock R,Fisher S,Spillane J,Ise C,Shaw D,Torop P

更新日期：1975-08-01 00:00:00

abstract：:The primary objective of the current investigation was to establish the pharmacokinetic characteristics of oxymetazoline and tetracaine's primary metabolite, para-butylaminobenzoic acid (PBBA), after the intranasal administration of oxymetazoline/tetracaine. Thirty-six subjects contributing a total of 1791 plasma conc...

journal_title：Journal of clinical pharmacology

authors： Cacek AT,Gobburu JV,Gopalakrishnan M

更新日期：2017-02-01 00:00:00

abstract：:This study was undertaken to assess the bioequivalence between a new formulation of propofol 2% and the commercially available product Diprivan. Secondary objectives were to compare the times to onset of and emergence from hypnosis, the hemodynamic effects, and the safety profiles. Twelve healthy male volunteers were ...

journal_title：Journal of clinical pharmacology

authors： Abad-Santos F,Gálvez-Múgica MA,Santos MA,Novalbos J,Gallego-Sandín S,Méndez P,Casimiro C,Gilsanz F

更新日期：2003-04-01 00:00:00

abstract：:Coronary heart disease, hypertension, and dyslipidemia are highly prevalent and commonly coexist in people who are middle-aged and older. Previous data suggested that lowering cholesterol concentrations in individuals at high risk of cardiovascular disease improved clinical outcomes. Xuezhikang, a partial extract of r...

journal_title：Journal of clinical pharmacology

authors： Li JJ,Lu ZL,Kou WR,Chen Z,Wu YF,Yu XH,Zhao YC,Chinese Coronary Secondary Prevention Study Group.

更新日期：2009-08-01 00:00:00

abstract：:The human cytochrome P450 (CYP) isoforms mediating nortriptyline 10-hydroxylation have been identified using kinetic studies on heterologously expressed human CYPs and chemical inhibition studies on human liver microsomes. Nortriptyline was metabolized to E-10-hydroxynortriptyline by human lymphoblast-expressed CYPs 2...

journal_title：Journal of clinical pharmacology

authors： Venkatakrishnan K,von Moltke LL,Greenblatt DJ

更新日期：1999-06-01 00:00:00

abstract：:To investigate the impact of cytochrome P450 (CYP) genetic polymorphisms CYP2B6, CYP2C19, and CYP3A5 on mRNA expression, cyclophosphamide/4-hydroxycyclophosphamide pharmacokinetics, and treatment outcomes of the R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) in Chinese patients ...

journal_title：Journal of clinical pharmacology

authors： Shu W,Chen L,Hu X,Zhang M,Chen W,Ma L,Liu X,Huang J,Pang T,Li J,Zhang Y

更新日期：2017-07-01 00:00:00

abstract：:A double-blind, crossover study was carried out to compare the antihypertensive efficacy of the long-acting ACE inhibitor trandolapril 1 mg administered once daily and 0.5 mg twice daily in 31 patients with mild to moderate essential hypertension. After randomization, patients entered a single-blind placebo period of ...

journal_title：Journal of clinical pharmacology

authors： Poirier L,Bourgeois J,Lacourcière Y

更新日期：1993-09-01 00:00:00

abstract：:The electrocardiographic (ECG) effects of rivastigmine treatment were assessed in mild to moderately severe Alzheimer's disease (AD) by analysis of four 26-week, double-blind, multicenter, placebo-controlled, phase III clinical trials. Of an initial 2791 patients, 77% completed treatment. Seventy-one percent required ...

journal_title：Journal of clinical pharmacology

authors： Morganroth J,Graham S,Hartman R,Anand R

更新日期：2002-05-01 00:00:00

abstract：:Sixteen essential hypertensive patients were entered into a protocol assessing the effect of Spirapril, an angiotensin-converting enzyme (ACE) inhibitor, on blood pressure, the renin-aldosterone system, and renal function. Specifically monitored before, during 6 weeks, and 6 months of Spirapril therapy were plasma ren...

journal_title：Journal of clinical pharmacology

authors： Reams GP,Lau A,Knaus V,Bauer JH

更新日期：1993-04-01 00:00:00

abstract：:The most recent International Conference on Harmonisation E14 Q&A document states that a separate positive control would not be necessary provided sufficiently high exposures are achieved in the early-phase studies. Realistically, a phase 1 study is unlikely to include a pharmacological positive control, and in cases ...

journal_title：Journal of clinical pharmacology

authors： Ferber G,Fernandes S,Täubel J

更新日期：2018-01-01 00:00:00

abstract：:Nateglinide (Starlix, SDZ DJN 608 or A-4166), a new insulinotropic agent, is intended to be administered prior to a meal in order to improve early insulin release in non-insulin-dependent diabetes mellitus patients. The effects of a meal on the oral bioavailability and pharmacodynamic actions of nateglinide were inves...

journal_title：Journal of clinical pharmacology

authors： Karara AH,Dunning BE,McLeod JF

更新日期：1999-02-01 00:00:00

abstract：:The pharmacokinetics of butorphanol nasal spray, with and without the coadministration of metoclopramide, were studied in 24 healthy women. In this crossover study all volunteers received 3 treatments: a single, 1-mg dose of butorphanol nasal spray, a single, 10-mg oral dose of metoclopramide, and a combination of a s...

journal_title：Journal of clinical pharmacology

authors： Vachharajani NN,Shyu WC,Barbhaiya RH

更新日期：1997-10-01 00:00:00

abstract：:The objective of this study was to measure the steady-state cerebrospinal fluid (CSF) concentration of LY450108 and LY451395 (positive modulators of AMPA receptors) in healthy subjects after the administration of 1 mg and 5 mg. Secondary objectives included the evaluation of safety, pharmacokinetics, and steady-state ...

journal_title：Journal of clinical pharmacology

authors： Jhee SS,Chappell AS,Zarotsky V,Moran SV,Rosenthal M,Kim E,Chalon S,Toublanc N,Brandt J,Coutant DE,Ereshefsky L

更新日期：2006-04-01 00:00:00

abstract：:Fifteen healthy women participated in a study to determine the effect of multiple doses of troglitazone on the pharmacokinetics of Ortho-Novum 1/35 (35 micrograms ethinyl estradiol [EE] and 1 mg norethindrone [NE]). Participants received three cycles (21 days each of active drug followed by 7 days without medication) ...

journal_title：Journal of clinical pharmacology

authors： Loi CM,Stern R,Koup JR,Vassos AB,Knowlton P,Sedman AJ

更新日期：1999-04-01 00:00:00

abstract：:The authors investigated the pharmacokinetics of mycophenolic acid over 1 year in 8 Caucasian women undergoing islet cell transplantation. Total mycophenolic acid AUC(0-12) mcg x h/mL before day 60 was 62.1-67.8, declining to 33.6-64.7 thereafter (P = .61). Median total trough concentrations were 1.16-2.90 mcg/mL. Unb...

journal_title：Journal of clinical pharmacology

authors： Jacobson PA,Green KG,Hering BJ

更新日期：2005-08-01 00:00:00

abstract：:Golimumab is a fully human antitumor necrosis factor alpha (TNF-alpha) monoclonal antibody that is being developed for intravenous and subcutaneous administration. To assess the pharmacokinetics and safety of the intravenous formulation of golimumab, 36 adult subjects with rheumatoid arthritis were randomly assigned t...

journal_title：Journal of clinical pharmacology

authors： Zhou H,Jang H,Fleischmann RM,Bouman-Thio E,Xu Z,Marini JC,Pendley C,Jiao Q,Shankar G,Marciniak SJ,Cohen SB,Rahman MU,Baker D,Mascelli MA,Davis HM,Everitt DE

更新日期：2007-03-01 00:00:00

abstract：:The frequency of hemodialysis-associated hemorrhage was studied prospectively in two successive, parallel, heparin-controlled studies using epoprostenol (PGI2; average dose, 4.1 ng/kg.min) as the sole antithrombotic agent. Sixty-three patients with active or recently active bleeding underwent 163 hemodialysis treatmen...

journal_title：Journal of clinical pharmacology

authors： Swartz RD,Flamenbaum W,Dubrow A,Hall JC,Crow JW,Cato A

更新日期：1988-09-01 00:00:00

abstract：:Peginterferon beta-1a was efficacious in a Phase 3 relapsing multiple sclerosis trial, and its safety profile was consistent with other beta interferons. This study evaluated the impact of renal impairment on the pharmacokinetics and pharmacodynamics (neopterin elevation; a biomarker of pharmacological activity induce...

journal_title：Journal of clinical pharmacology

authors： Hu X,Seddighzadeh A,Stecher S,Zhu Y,Goyal J,Matson M,Marbury T,Smith W,Nestorov I,Hung S

更新日期：2015-02-01 00:00:00

abstract：:T Cell Modulatory Peptide (TCMP-80), L-lysine-L-serine, is a synthetic dipeptide structurally related to a selected amino acid sequence in human immunoglobulin G. Based on in vitro and preclinical in vivo testing, TCMP-80 has immunomodulatory properties. This report describes the first administration of TCMP-80 to man...

journal_title：Journal of clinical pharmacology

authors： Eldon MA,Smith RA,Leese PT,Daigle AE,Katz DV,Richieri SP

更新日期：1990-04-01 00:00:00

abstract：:Ustekinumab, a human immunoglobulin G1 kappa (IgG1k) monoclonal antibody that binds with high affinity to human interleukin-12 and interleukin-23, has demonstrated efficacy in patients with psoriasis. The objective of this study was to perform exposure-response modeling to increase the understanding of reduction in di...

journal_title：Journal of clinical pharmacology

authors： Zhou H,Hu C,Zhu Y,Lu M,Liao S,Yeilding N,Davis HM

更新日期：2010-03-01 00:00:00

abstract：:Clinical pharmacology of L-asparaginase was compared by intramuscular and intravenous injections in 12 patients with metastatic cancer or leukemia. Following a single intramuscular injection at the gluteal site of L-asparaginase (10,000 IU/m2), the enzyme appeared in plasma as measured initially at 1 hour, but plateau...

journal_title：Journal of clinical pharmacology

authors： Ho DH,Yap HY,Brown N,Benjamin RS,Friereich EJ,Blumenschein GR,Bodey GP

更新日期：1981-02-01 00:00:00

abstract：:Several approaches are available to estimate the glomerular filtration rate (GFR) from the sinistrin clearance. To compare such approaches, GFR was estimated in six healthy volunteers, both after a bolus injection and a bolus dose followed by a 6-hour infusion. A recently developed high-performance liquid chromatograp...

journal_title：Journal of clinical pharmacology

authors： Buclin T,Pechère-Bertschi A,Séchaud R,Décosterd LA,Munafo A,Burnier M,Biollaz J

更新日期：1997-08-01 00:00:00

abstract：:Unresolved issues of ethical, methodological, and legal concerns in the use of normal healthy volunteers persist. Financial incentives in their recruitment offer a unique ethical dilemma because of questions surrounding payment. A review of literature was conducted to obtain research systematically examining volunteer...

journal_title：Journal of clinical pharmacology

authors： Tishler CL,Bartholomae S

更新日期：2002-04-01 00:00:00

abstract：:The hypotensive effect, kinetics, and concentration-response relationship of labetalol, alpha beta- and alpha 1-adrenoceptor blocking drug, were studied in seven women with a moderate-to-severe hypertension (averaged diastolic blood pressure [DBP] of 100 to 120 mm Hg measured during a 1- to 2-day hospitalization perio...

journal_title：Journal of clinical pharmacology

authors： Saotome T,Minoura S,Terashi K,Sato T,Echizen H,Ishizaki T

更新日期：1993-10-01 00:00:00