Cortisone induced bone changes and its response to lipid clearing agents.

Abstract:

:Thirty-two rabbits were used experimentally to study the effect of cortisone in bone, lungs, kidneys, and liver. Cortisone does induce abnormal increases in the serum cholesterol, fatty metamorphosis of the liver and the fatty emboli of the subchondral vessels of the femoral heads. Clofibrate therapy appeared to modify the cortisone induced changes as evidenced by a lower serum cholesterol level, prevention or lessening of the increase in the marrow fat cell size. This might significantly improve microcirculation of the femoral head.

journal_name

Clin Orthop Relat Res

authors

Wang GJ,Moga DB,Richemer WG,Sweet DE,Reger SI,Thompson RC

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

81-5

issue

130

eissn

0009-921X

issn

1528-1132

pub_type

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