Ovarian irradiation and prednisone following surgery and radiotherapy for carcinoma of the breast.

abstract：:The majority of breast cancer deaths are because of ineffective treatment of metastatic disease. We previously identified a subpopulation of cells in human breast cancer cell lines that demonstrate high activity of aldehyde dehydrogenase (ALDH) and high expression of CD44. These ALDH(hi)CD44(+) cells displayed enhance...

journal_title：Breast cancer research and treatment

authors： Croker AK,Allan AL

更新日期：2012-05-01 00:00:00

abstract：:The pharmacokinetics of free and different liposomal formulations of hexadecylphosphocholine (HPC) was investigated in tumor-bearing (human mammary tumor MaTu) and tumor-free mice after intravenous and intraperitoneal administration. The levels of HPC were evaluated at different times in serum, normal tissues, and tum...

journal_title：Breast cancer research and treatment

authors： Arndt D,Zeisig R,Fichtner I,Teppke AD,Fahr A

更新日期：1999-11-01 00:00:00

abstract：:Findings from epidemiologic studies of oxidative stress biomarkers and breast cancer have been mixed, although no studies have focused on estrogen receptor-negative (ER-) tumors which may be more strongly associated with oxidative stress. We examined prediagnostic plasma fluorescent oxidation products (FlOP), a global...

journal_title：Breast cancer research and treatment

authors： Hirko KA,Fortner RT,Hankinson SE,Wu T,Eliassen AH

更新日期：2016-07-01 00:00:00

abstract：:The site of several lectin receptors in human mammary tumors and stroma was studied with the electron microscope. The advantage of the ultrastructural over light microscopic study was that lectin receptors could be localized with precision on the different cell types of the tumor and stroma. Eighteen human mammary car...

journal_title：Breast cancer research and treatment

authors： Calafat J,Janssen H

更新日期：1984-01-01 00:00:00

abstract：:The present study consists of 1,238 women with unilateral breast cancer treated with modified radical mastectomy living in the geographic area of Haukeland Hospital. Their weight and height had been measured years before presentation of the disease. Age-adjusted Quetelet's index (weight/height2) showed that obese wome...

journal_title：Breast cancer research and treatment

authors： Maehle BO,Tretli S

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Radiotherapy (RT) constitutes an important part of breast cancer treatment. However, triple negative breast cancers (TNBC) exhibit remarkable resistance to most therapies, including RT. Developing new ways to radiosensitize TNBC cells could result in improved patient outcomes. The M2 isoform of pyruvate kinase ...

journal_title：Breast cancer research and treatment

authors： Zhang L,Bailleul J,Yazal T,Dong K,Sung D,Dao A,Gosa L,Nathanson D,Bhat K,Duhachek-Muggy S,Alli C,Dratver MB,Pajonk F,Vlashi E

更新日期：2019-11-01 00:00:00

abstract：:Wide fluctuations in results obtained by different laboratories for the content of estrogen receptors from a single source of tissue powder were reported by several investigators at the 1979 NCI Consensus Committee Meeting for Steroid Receptors in Breast Cancer and were further supported by data collected by our labor...

journal_title：Breast cancer research and treatment

authors： Raam S,Gelman R,Faulkner J,White GM,Cohen JL

更新日期：1982-01-01 00:00:00

abstract：:Clinical evidence regarding the value of MRI for therapy responses assessment in breast cancer is increasing. The objective of this study is to compare the diagnostic capability of diffusion-weighted MR imaging (DW-MRI) and contrast-enhanced MR imaging (CE-MRI) to evaluate and predict pathological response in breast c...

journal_title：Breast cancer research and treatment

authors： Wu LM,Hu JN,Gu HY,Hua J,Chen J,Xu JR

更新日期：2012-08-01 00:00:00

abstract：:To investigate the expression levels of CXCL10 and CXCR3 in tumors from breast cancer patients randomized to adjuvant tamoxifen treatment or no endocrine treatment, in order to further study the connection to prognosis and prediction of tamoxifen treatment outcome. Immunohistochemistry on tissue microarrays from 912 b...

journal_title：Breast cancer research and treatment

authors： Hilborn E,Sivik T,Fornander T,Stål O,Nordenskjöld B,Jansson A

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:The role of sentinel lymph node biopsy (SLNB) in breast cancer patients who undergo neoadjuvant chemotherapy (NAC) remains controversial. This study aims to investigate if axillary lymph node dissection (ALND) could be safely omitted after a negative SLNB in cN1/2 patients who become cN0 after NAC. METHODS:We ...

journal_title：Breast cancer research and treatment

authors： Damin AP,Zancan M,Melo MP,Biazus JV

更新日期：2020-11-09 00:00:00

abstract：:Transgender (TG) persons often receive, or self-treat, with cross-sex hormone (CSH) treatments as part of their treatment plans, with little known about their incidence of breast cancer. This information gap can lead to disparities in the provision of transgender health care. The purpose of the study was to examine th...

journal_title：Breast cancer research and treatment

authors： Brown GR,Jones KT

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The malignant upgrade rate of flat epithelial atypia (FEA) diagnosed on core needle biopsy varies between 0 and 30%. Excision versus observation with radiological follow-up for these lesions remains controversial. We hypothesize that the local rate of FEA is low and that close radiological surveillance is a rea...

journal_title：Breast cancer research and treatment

authors： DiPasquale A,Silverman S,Farag E,Peiris L

更新日期：2020-01-01 00:00:00

abstract：:Medroxyprogesterone acetate (MPA) is well recognized to have beneficial effects for the treatment of advanced breast cancer which are comparable to those achieved with other forms of endocrine therapy. Using mammary tumors induced in the rat by dimethylbenz(a)anthracene (DMBA) as a model, we have studied the possibili...

journal_title：Breast cancer research and treatment

authors： Labrie F,Li S,Bélanger A,Côté J,Mérand Y,Lepage M

更新日期：1993-01-01 00:00:00

abstract：:In contrast to antigen-specific alphabeta-T cells (adaptive immune system), gammadelta-T cells can recognize and lyse malignantly transformed cells almost immediately upon encounter in a manner that does not require the recognition of tumor-specific antigens (innate immune system). Given the well-documented capacity o...

journal_title：Breast cancer research and treatment

authors： Beck BH,Kim HG,Kim H,Samuel S,Liu Z,Shrestha R,Haines H,Zinn K,Lopez RD

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Analysis of cytokines and growth factors in human milk offers a noninvasive approach for studying the microenvironment of the postpartum breast, which may better reflect tissue levels than testing blood samples. Given that Black women have a higher incidence of early-onset breast cancers than White women, we...

journal_title：Breast cancer research and treatment

authors： Murphy J,Pfeiffer RM,Lynn BCD,Caballero AI,Browne EP,Punska EC,Yang HP,Falk RT,Anderton DL,Gierach GL,Arcaro KF,Sherman ME

更新日期：2018-11-01 00:00:00

abstract：:This study analyzes the relationship between coxsackie-adenovirus receptor (CAR) expression (transmembrane and soluble isoforms) and hormone sensitivity in 95 breast cancers. Furthermore, prognostic significance of the expression of the various CAR isoforms was investigated. In addition, inducibility of CAR expression...

journal_title：Breast cancer research and treatment

authors： Auer D,Reimer D,Porto V,Fleischer M,Roessler J,Wiedemair A,Marth C,Müller-Holzner E,Daxenbichler G,Zeimet AG

更新日期：2009-07-01 00:00:00

abstract：:Adjuvant cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) have proven highly effective in rapidly proliferating breast cancer (RPBC). It has also been seen that sequential administration of doxorubicin and CMF is superior to their alternation, especially in indolent tumors. In a phase III study, we evaluated w...

journal_title：Breast cancer research and treatment

authors： Amadori D,Silvestrini R,De Lena M,Boccardo F,Rocca A,Scarpi E,Schittulli F,Brandi M,Maltoni R,Serra P,Ponzone R,Biglia N,Gianni L,Tienghi A,Valerio MR,Bonginelli P,Amaducci L,Faedi M,Baldini E,Paradiso A

更新日期：2011-02-01 00:00:00

abstract：:The transcriptome of breast cancers have been extensively screened with microarrays and large sets of genes associated with clinical features have been established. The aim of this study was to validate original gene sets on a large cohort of raw breast cancer microarray data with known clinical follow-up. We recovere...

journal_title：Breast cancer research and treatment

authors： Györffy B,Schäfer R

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:The aromatase inhibitors (AIs) are increasingly surpassing tamoxifen as the endocrine treatment of choice for postmenopausal breast cancer patients. With their increasing use, there is concern that they are being inadvertently prescribed to pre- and peri-menopausal women. METHODS:As part of a continuing med...

journal_title：Breast cancer research and treatment

authors： Gainford MC,McCready D,Clemons M

更新日期：2006-04-01 00:00:00

abstract：:The clinical benefit of eribulin versus capecitabine was evaluated using health-related quality of life (HRQoL) data from a phase 3 randomized trial in patients with pretreated advanced/metastatic breast cancer (ClinicalTrials.gov identifier: NCT00337103). The study population has been described previously (Kaufman et...

journal_title：Breast cancer research and treatment

authors： Cortes J,Hudgens S,Twelves C,Perez EA,Awada A,Yelle L,McCutcheon S,Kaufman PA,Forsythe A,Velikova G

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Previous meta-analyses have examined the prognosis of women with pregnancy-associated breast cancer (PABC) as well as pregnancy that follows breast cancer diagnosis. Since then, many additional studies have been performed. We conducted an updated meta-analysis to examine the prognosis for women who become pre...

journal_title：Breast cancer research and treatment

authors： Hartman EK,Eslick GD

更新日期：2016-11-01 00:00:00

abstract：:Elevated body weight is a risk factor for postmenopausal breast cancer and is associated with increased incidence of spontaneous and chemically induced mammary tumors (MTs) in rodents. In this study, genetically obese Lep(ob)Lep(ob) female mice that overexpress human TGF-alpha (transforming growth factor-alpha) were u...

journal_title：Breast cancer research and treatment

authors： Cleary MP,Phillips FC,Getzin SC,Jacobson TL,Jacobson MK,Christensen TA,Juneja SC,Grande JP,Maihle NJ

更新日期：2003-02-01 00:00:00

abstract：:Paclitaxel and vinorelbine are among the most active new agents in metastatic breast cancer. Both in vitro and in vivo studies have shown that the combined administration of these two microtubule-targeting agents is feasible and worthwhile. Based on the promising preclinical data, patients with metastatic breast cance...

journal_title：Breast cancer research and treatment

authors： Tortoriello A,Facchini G,Caponigro F,Santangelo M,Benassai G,Persico G,Citarella A,Carola M,Marzano N,Iaffaioli RV

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:To examine the trends in the prevalence of breast cancer risk factors in relation to breast cancer incidence trends and to explore whether the changes in risk factors differed by ethnicity in Hawaii over a 25-year period. METHODS:We pooled 17 population-based epidemiological studies conducted in Hawaii be...

journal_title：Breast cancer research and treatment

authors： Maskarinec G,Zhang Y,Takata Y,Pagano I,Shumay DM,Goodman MT,Le Marchand L,Nomura AM,Wilkens LR,Kolonel LN

更新日期：2006-07-01 00:00:00

abstract：:The expression of amphiregulin (AR), heregulin (HRG), and cripto-1 (CR-1) mRNA transcripts was assessed in 60 human primary breast carcinoma. AR and HRG transcripts were expressed respectively in 58% and 25% of the carcinomas as measured by Northern blot analysis. CR-1 mRNA was found in 77% of the carcinomas using Rev...

journal_title：Breast cancer research and treatment

authors： Normanno N,Kim N,Wen D,Smith K,Harris AL,Plowman G,Colletta G,Ciardiello F,Salomon DS

更新日期：1995-09-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) is negative regulator of cell proliferation and the cell cycle, and plasma levels of TGF-β1 are twice as high in TGF-β1 -509 T homozygotes as in -509 C homozygotes. Published studies on the association between the TGF-β1 gene -509 C/T polymorphism and breast cancer risk are incon...

journal_title：Breast cancer research and treatment

authors： Woo SU,Park KH,Woo OH,Yang DS,Kim AR,Lee ES,Lee JB,Kim YH,Kim JS,Seo JH

更新日期：2010-11-01 00:00:00

abstract：PURPOSE:Dysregulation of HER2 signaling pathway in breast cancer is well documented. Our bioinformatics analysis predicted hsa-miR-512-3p (miR-512-3p) as a bona fide regulator of HER2 as well as HER3, PIK3R2, and AKT1 genes. Then, we intended to examine the effect of miR-512-3p on the predicted target genes that are in...

journal_title：Breast cancer research and treatment

authors： Mohamadzade Z,Mahjoubi F,Soltani BM

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:After experiencing a distant recurrence, breast cancer patients have a poor prognosis; fewer than 5% survive for ten or more years. However, the time to death is highly variable, ranging from a few months to many years. The purpose of this study is to identify, in a large hospital-based series of patients wi...

journal_title：Breast cancer research and treatment

authors： Sopik V,Sun P,Narod SA

更新日期：2019-01-01 00:00:00

abstract：:The polypeptide hormone prolactin (Prl), acting through its cell surface receptors, promotes growth and differentiation in normal and malignant breast cells. We demonstrate herein that two Prl-responsive cell lines, NOG-8 normal mouse mammary epithelial and T47D human breast cancer cells, respond to Prl by rapid and t...

journal_title：Breast cancer research and treatment

authors： Das R,Vonderhaar BK

更新日期：1996-01-01 00:00:00

abstract：:Over the last several years, evidence has accumulated to support the idea that rare Ha-ras polymorphisms are associated with inherited susceptibility to certain human cancers. A recent epidemiologic study conducted at our institution found a significant association specifically with breast cancer, although the mechani...

journal_title：Breast cancer research and treatment

authors： Conway K,Edmiston S,Fried DB,Hulka BS,Garrett PA,Liu ET

更新日期：1995-07-01 00:00:00