Abstract:
:The effects of dopamine receptor and alpha-adrenoceptor agonists and antagonists on the stimulation-evoked overflow of radioactivity from strips of dog saphenous vein previously loaded with [3H]-noradrenaline have been examined alone and in combination. In the presence of neuronal and extraneuronal catecholamine uptake inhibitors, noradrenaline (0.1-1 X 10(-6)M) and dopamine (0.01-1 X 10(-6)M) both inhibited the stimulation-evoked overflow of radioactivity. Sulpiride (1 X 10(-6)M) was without effect and prazosin (1 X 10(-7)M) had little effect on stimulation-evoked overflow but yohimbine enhanced it approximately 2 fold; the effect of yohimbine was similar at concentrations of 1 X 10(-7) and 1 X 10(-6)M. Sulpiride abolished the inhibitory effect of dopamine on stimulation-evoked overflow, but was without effect against noradrenaline. When allowance was made for the effects of yohimbine, alone, on overflow, yohimbine (1 X 10(-7)M) had no effect against dopamine and minimal effects against noradrenaline. A similar result was obtained when the concentration of yohimbine was increased to 1 X 10(-6)M. Prazosin did not antagonize the effect of noradrenaline. In the absence of the uptake inhibitors, clonidine (0.01-1 X 10(-5)M) inhibited stimulation-evoked overflow of radioactivity. Yohimbine (1 X 10(-6)M) was without effect on its own and antagonized the effects of clonidine at a concentration of 0.1 X 10(-5)M, but not at 0.01 or 1.0 X 10(-5)M. These findings suggest that dopamine inhibits overflow by stimulating presynaptic dopamine receptors on the terminals of the noradrenergic nerves supplying the dog saphenous vein. The interaction between yohimbine and noradrenaline is discussed in terms of the current concepts of control of transmitter release mediated via presynaptic alpha 2-adrenoceptors.
journal_name
Br J Pharmacoljournal_title
British journal of pharmacologyauthors
Baker DJ,Drew GM,Hilditch Adoi
10.1111/j.1476-5381.1984.tb10098.xsubject
Has Abstractpub_date
1984-03-01 00:00:00pages
457-64issue
3eissn
0007-1188issn
1476-5381journal_volume
81pub_type
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更新日期:1986-12-01 00:00:00
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更新日期:2017-12-01 00:00:00
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更新日期:2007-11-01 00:00:00
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更新日期:1999-08-01 00:00:00
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更新日期:1998-08-01 00:00:00
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更新日期:1969-05-01 00:00:00
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更新日期:1987-12-01 00:00:00
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更新日期:2019-11-01 00:00:00
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更新日期:1993-01-01 00:00:00
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更新日期:1997-01-01 00:00:00
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更新日期:1974-06-01 00:00:00
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更新日期:1973-06-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2000-06-01 00:00:00
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更新日期:1987-03-01 00:00:00