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Induction of rat hepatic long-chain acyl-CoA hydrolases by various peroxisome proliferators.

Abstract：

:Induction of cytosolic long-chain acyl-CoA hydrolases was investigated in rat liver after administration of various peroxisome proliferators and related compounds. Treatment of rats with di-(2-ethylhexyl)-phthalate, di-(2-ethylhexyl)-adipate or tiadenol induced hydrolases I and II, while acetylsalicylic acid induced only hydrolase II. Among the various phenoxyacetic acid derivatives and related compounds, 2,4,5-trichlorophenoxyacetic acid, 2-(4-chlorophenoxy)-2-methylacetic acid, 2-(2-chlorophenoxy)-2-methylpropionic acid and clofibric acid induced both hydrolases I and II, whereas 2, 4-dichlorophenoxyacetic acid induced only hydrolase II. All nine of the above-mentioned inducers also markedly increased the activity of peroxisomal beta-oxidation. Other compounds tested (2-chlorophenoxyacetic acid, 4-chlorophenoxyacetic acid, 4-chlorophenol, phenoxyacetic acid and phenoxy-2-methylacetic acid) were ineffective as inducers. These results suggest that inducers of acyl-CoA hydrolase II also enhance peroxisomal beta-oxidation activity, but do not necessarily induce acyl-CoA hydrolase I. The structure-inducing activity relationships of these compounds are discussed.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Katoh H,Nakajima S,Kawashima Y,Kozuka H,Uchiyama M

doi

10.1016/0006-2952(84)90517-3

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

1081-5

issue

7

eissn

0006-2952

issn

1873-2968

pii

0006-2952(84)90517-3

journal_volume

33

pub_type

杂志文章

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