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The effects of anaesthetics on the uptake and release of amino acid neurotransmitters in thalamic slices.

Abstract：

:1 The effect of thiopentone, methohexitone, urethane and ketamine on the uptake and release of gamma-aminobutyric acid (GABA) and D-aspartate by rat thalamic slices has been investigated. 2 A high, supra-anaesthetic concentration of methohexitone increased the uptake of both D-aspartate and GABA. 3 None of the anaesthetics used had any detectable effect upon the spontaneous release of either amino acid. 4 Urethane and ketamine had no effect upon the K+-stimulated release of either amino acid. 5 Methohexitone and thiopentone produced a biphasic dose-response on the K+-stimulated release of both amino acids; low concentrations enhanced release, high concentrations depressed release. 6 Bicuculline hydrochloride and picrotoxin both significantly reduced the barbiturate-induced enhancement of K+-stimulated amino acid release, but did not significantly alter the depression of K+-stimulated release at higher barbiturate concentrations. 7 Baclofen, either alone (1 microM to 1 mM), or tested against the barbiturates, had no detectable effect.

journal_name

Br J Pharmacol

journal_title

British journal of pharmacology

authors

Kendall TJ,Minchin MC

doi

10.1111/j.1476-5381.1982.tb08776.x

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

219-27

issue

1

eissn

0007-1188

issn

1476-5381

journal_volume

75

pub_type

杂志文章

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