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Chromosome deletion mapping of interspersed low-copy repetitive DNA.

Abstract：

:A cloned 2.2 Eco RI segment of interspersed repetitive DNA was hybridized to genomic DNA from a mentally retarded patient with an interstitial deletion in the long arm of one chromosome 12 (12q-). Under hybridization conditions of high stringency, one prominent 2.2-kilobase (kb) Eco RI fragment demonstrated reduced autoradiographic intensity in the 12q- sample compared with several normal controls. These findings indicate that the genomic location for one of the highly or perfectly homologous 2.2-kb Eco RI fragments is in chromosome region 12q21q22, and suggest that a low-copy repetitive DNA probe as used here may have practical utility, as in detecting small deletions or other chromosome alterations.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Funderburk SJ,Sparkes RS,Klisak I,Law ML

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

769-76

issue

4

eissn

0002-9297

issn

1537-6605

journal_volume

36

pub_type

杂志文章

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