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Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells.

Abstract：

:Human neuroblastoma cells often are monosomic for the distal portion of 1p (1p36). We report that the deleted 1p material in cells of neuroblastoma lines is preferentially replaced by material from chromosome 17, resulting from an unbalanced 1;17 translocation. Chromosome 17 often acquires instability, followed by the integration of fragments into various marker chromosomes. As a consequence, 17q material can increase over 17p material. The nonrandom frequency of 1;17 translocations appears to indicate an as-yet-undefined contribution to neuroblastoma development.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Savelyeva L,Corvi R,Schwab M

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

334-40

issue

2

eissn

0002-9297

issn

1537-6605

journal_volume

55

pub_type

杂志文章

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