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The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing spondylitis.

Abstract：

:Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS.

journal_name

Am J Hum Genet

journal_title

American journal of human genetics

authors

Timms AE,Crane AM,Sims AM,Cordell HJ,Bradbury LA,Abbott A,Coyne MR,Beynon O,Herzberg I,Duff GW,Calin A,Cardon LR,Wordsworth BP,Brown MA

doi

10.1086/424695

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

587-95

issue

4

eissn

0002-9297

issn

1537-6605

pii

S0002-9297(07)62710-4

journal_volume

75

pub_type

杂志文章

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