Abstract:
:Nitrendipine, a calcium entry blocker, was administered by gavage (3 mg/100 g body weight/day) to rats with prolonged angiotensin-II-(AII) induced hypertension. AII was infused by osmotic minipump implanted subcutaneously. Persistent hypertension was established after 5 days. Normotensive control rats had empty sham pumps. Nitrendipine, administered from day 11 to 15 after pump implantation, normalized blood pressure consistently in AII rats, whereas it had no significant hypotensive effect in controls. Renal clearance experiments in anesthetized rats revealed that nitrendipine reversed all noted abnormalities of AII-infused rats, including hypertension and reductions in glomerular filtration rate, renal blood flow, and urinary sodium excretion. When receiving nitrendipine, sham controls did not show significant changes in blood pressure, renal function, or natriuresis. The results demonstrate that oral administration of nitrendipine is highly effective in normalizing blood pressure during prolonged AII-induced hypertension. The antihypertensive effect is achieved by this calcium entry blocker's vasodilatory action, supported by a marked natriuretic effect. By contrast, blood pressure and renal function of normotensive control rats were not appreciably affected by oral nitrendipine.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Sterzel RB,Huelsemann JL,McKenzie DE,Wilcox CSsubject
Has Abstractpub_date
1984-01-01 00:00:00pages
S1024-7eissn
0160-2446issn
1533-4023journal_volume
6 Suppl 7pub_type
杂志文章abstract::The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. In addition to its well-established role in maintaining vascular homeostasis, the endothelium has been increasingly recogniz...
journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
doi:10.1097/00005344-199511000-00002
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journal_title:Journal of cardiovascular pharmacology
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pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular pharmacology
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更新日期:1986-07-01 00:00:00
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
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更新日期:1994-03-01 00:00:00
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular pharmacology
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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更新日期:1991-01-01 00:00:00
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-01-01 00:00:00
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章,评审
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journal_title:Journal of cardiovascular pharmacology
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更新日期:1989-01-01 00:00:00
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journal_title:Journal of cardiovascular pharmacology
pub_type: 临床试验,杂志文章,meta分析
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journal_title:Journal of cardiovascular pharmacology
pub_type: 杂志文章
doi:10.1097/00005344-198409000-00017
更新日期:1984-09-01 00:00:00
abstract::Reversal of left ventricular hypertrophy (LVH) is an important target of antihypertensive therapy. Nonpharmacological approaches such as weight reduction and exercise training have favorable effects on other risk factors. However, there are few data on their effects on LVH. Athletes have eccentric rather than concentr...
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pub_type: 杂志文章,评审
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