Abstract:
:In order to allow for real dielectric properties of a solvent in calculating of electrostatic characteristics of strongly charged polyions such as DNA in salt solution we consider a simple model of linear dielectric response of a medium. The interactions between charged particles are treated in the framework of self-consistent-field approximation. The basic characteristic of the problem, electrostatic potential, can be found from the solution of non-linear integro-differential equation. Specifically we consider so-called quasimacroscopic model where dielectric response of a medium depends only on the distance from the polyion. Application of the approach for calculating of the B-to-Z free energy qualitatively retains the main conclusion obtained previously within the model with fixed dielectric constant: non-monotonous behavior of the free energy differences as a function of ionic strength. At the same time, essential sensitivity of the results to specific values of dielectric parameters is observed.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Lukashin AV,Beglov DB,Frank-Kamenetskii MDdoi
10.1080/07391102.1991.10507933subject
Has Abstractpub_date
1991-12-01 00:00:00pages
517-23issue
3eissn
0739-1102issn
1538-0254journal_volume
9pub_type
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