Abstract:
:Over the years the structural properties of nucleic acids have been of interest, providing data that may be of importance for DNA and RNA organization and function in the cell. We have attempted to look for the formation of parallel RNA-RNA duplexes in vitro. RNA molecules comprising complementary in the same polarity alternating stretches of A and U of increasing length were enzymatically synthesized and annealed in physiological conditions. The fractionation in the denaturing polyacrylamide gels revealed the formation of two types of full-length parallel RNase A-stable duplexes established either by A-U or by A-A and U-U self pairs. These results suggest novel structural properties of versatile RNA molecules that potentially may be realized in vivo.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Tchurikov NA,Ponomarenko NA,Golova YB,Chernov BKdoi
10.1080/07391102.1995.10508860subject
Has Abstractpub_date
1995-12-01 00:00:00pages
507-13issue
3eissn
0739-1102issn
1538-0254journal_volume
13pub_type
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