Nucleosome positioning by sequence, state of the art and apparent finale.

Abstract:

:All major suggestions about the nucleosome positioning sequence pattern(s) are overviewed. Two basic binary periodical patterns are well established: in purine/pyrimidine alphabet - YRRRRRYYYYYR and in strong/weak alphabet -SWWWWWSSSSSW. Their merger in four-letter alphabet sequence coincides with first ever complete matrix of nucleosome DNA bendability derived from very large database of nucleosome DNA sequences. Its simplified linear form is CGGAAATTTCCG. Several independent ways of derivation of the same pattern are described. It appears that the pattern represents an ultimate solution of long-standing problem of nucleosome positioning, and provides simple means for nucleosome mapping on sequences with single-base resolution.

journal_name

J Biomol Struct Dyn

authors

Trifonov EN

doi

10.1080/073911010010524944

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

741-6

issue

6

eissn

0739-1102

issn

1538-0254

pii

c4300/Nucleosome-Positioning-by-Sequence-State-of-

journal_volume

27

pub_type

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