Abstract:
:All major suggestions about the nucleosome positioning sequence pattern(s) are overviewed. Two basic binary periodical patterns are well established: in purine/pyrimidine alphabet - YRRRRRYYYYYR and in strong/weak alphabet -SWWWWWSSSSSW. Their merger in four-letter alphabet sequence coincides with first ever complete matrix of nucleosome DNA bendability derived from very large database of nucleosome DNA sequences. Its simplified linear form is CGGAAATTTCCG. Several independent ways of derivation of the same pattern are described. It appears that the pattern represents an ultimate solution of long-standing problem of nucleosome positioning, and provides simple means for nucleosome mapping on sequences with single-base resolution.
journal_name
J Biomol Struct Dynjournal_title
Journal of biomolecular structure & dynamicsauthors
Trifonov ENdoi
10.1080/073911010010524944subject
Has Abstractpub_date
2010-06-01 00:00:00pages
741-6issue
6eissn
0739-1102issn
1538-0254pii
c4300/Nucleosome-Positioning-by-Sequence-State-of-journal_volume
27pub_type
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journal_title:Journal of biomolecular structure & dynamics
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