Multiple systems organ failure. Modulation of hepatocyte protein synthesis by endotoxin activated Kupffer cells.

Abstract:

:The etiology of hepatic insufficiency associated with the multiple systems organ failure (MSOF) syndrome is unclear. The authors have investigated the possibility that a macrophage/Kupffer cell mediated modulation of hepatocyte function may play a role in this phenomenon. Isolated rat hepatocytes were cultured, and their rate of protein synthesis was measured by cpm of 3H leucine incorporation into protein. Nonparenchymal rat liver cells (NPC) comprised of 35-40% Kupffer cells were added to hepatocytes to establish a co-culture with or without endotoxin. Neither NPC alone nor endotoxin alone affected hepatocyte protein synthesis. However, in the presence of endotoxin, NPC caused a marked diminution of hepatocyte protein synthesis (4,396 +/- 449 cpm) compared with control hepatocytes (10,943 +/- 623 cpm). No change in microscopic morphology or ability to exclude trypan blue occurred. This modulation of hepatocyte function by an endotoxin stimulated Kupffer cell preparation may, in part, represent the mechanism of hepatic insufficiency associated with the MSOF syndrome.

journal_name

Ann Surg

journal_title

Annals of surgery

authors

Keller GA,West MA,Cerra FB,Simmons RL

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

87-95

issue

1

eissn

0003-4932

issn

1528-1140

journal_volume

201

pub_type

杂志文章
  • Is Less More? A Microsimulation Model Comparing Cost-effectiveness of the Revised American Thyroid Association's 2015 to 2009 Guidelines for the Management of Patients With Thyroid Nodules and Differentiated Thyroid Cancer.

    abstract:OBJECTIVE:To assess relative clinical and economic performance of the revised American Thyroid Association (ATA) thyroid cancer guidelines compared to current standard of care. BACKGROUND:Diagnosis of thyroid cancer in the United States has tripled whereas mortality has only marginally increased. Most patients present...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003074

    authors: White C,Weinstein MC,Fingeret AL,Randolph GW,Miyauchi A,Ito Y,Zhan T,Ali A,Gazelle GS,Lubitz CC

    更新日期:2020-04-01 00:00:00

  • Prophylactic and preventive antibiotic therapy: timing, duration and economics.

    abstract::Previous studies have demonstrated that administered antibiotics must be active against major anticipated pathogens and must have reached sufficient concentrations in the tissue or body fluid at risk by the time of bacterial challenge if prophylactic therapy is to be maximally effective in reducing the infection rate ...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-197906000-00004

    authors: Stone HH,Haney BB,Kolb LD,Geheber CE,Hooper CA

    更新日期:1979-06-01 00:00:00

  • Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias.

    abstract:OBJECTIVE:The aim of this study was to evaluate the results of pancreatic resection in pancreatic endocrine neoplasias (PENs) in patients affected by multiple endocrine neoplasia type 1 (MEN1) syndrome. BACKGROUND:Since these tumors often show an indolent course, the role of diagnostic procedures and type of surgical ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000218073.77254.62

    authors: Tonelli F,Fratini G,Nesi G,Tommasi MS,Batignani G,Falchetti A,Brandi ML

    更新日期:2006-07-01 00:00:00

  • Narcotic Free Cervical Endocrine Surgery: A Shift in Paradigm.

    abstract:BACKGROUND AND OBJECTIVE:The opioid epidemic has stimulated initiatives to reduce the number of unnecessary narcotic prescriptions. We adopted an opt-in prescription system for patients undergoing ambulatory cervical endocrine surgery (CES). We hypothesized that empowering patients to decide whether or not to receive n...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003443

    authors: Ruffolo LI,Jackson KM,Juviler P,Kaur R,Chennell T,Glover DM,Linehan DC,Moalem J

    更新日期:2019-07-06 00:00:00

  • Biostatistical basis of elective node dissection for malignant melanoma.

    abstract::During the years 1954 through 1964, 259 individuals with primary malignant melanoma had an elective node dissection. Microscopic metastases were found in 15% of these patients. The presence of only a microscopic focus of involvement gave a 10-year cure rate of 67%; metastasis larger than a microscopic focus in a singl...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197707000-00014

    authors: Fortner JG,Woodruff J,Schottenfeld D,Maclean B

    更新日期:1977-07-01 00:00:00

  • Pure laparoscopic left lateral sectionectomy in living donors: from innovation to development in France.

    abstract:OBJECTIVE:In this study, we report the results obtained from 70 living donors in France. BACKGROUND:Left lateral sectionectomy for pediatric live donor liver transplantation is a well-standardized surgical procedure. Our team introduced the laparoscopic approach to live donation in 2002, and the reproducibility and sa...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000000642

    authors: Scatton O,Katsanos G,Boillot O,Goumard C,Bernard D,Stenard F,Perdigao F,Soubrane O

    更新日期:2015-03-01 00:00:00

  • Intermittent Pneumatic Compression in Addition to Standard Prophylaxis of Postoperative Venous Thromboembolism in Extremely High-risk Patients (IPC SUPER): A Randomized Controlled Trial.

    abstract:OBJECTIVE:To assess the efficacy of adjunctive IPC to standard prophylaxis of postoperative VTE in patients at extremely high-risk. SUMMARY OF BACKGROUND DATA:The standard prophylaxis for postoperative VTE is insufficient in extremely high-risk patients. It is unclear whether an adjunctive use of IPC would result in a...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000004556

    authors: Lobastov K,Sautina E,Alencheva E,Bargandzhiya A,Schastlivtsev I,Barinov V,Laberko L,Rodoman G,Boyarintsev V

    更新日期:2020-11-12 00:00:00

  • Clinical characteristics and current management of medically refractory unstable angina.

    abstract::Of 531 patients admitted to the Duke Coronary Care Unit with unstable angina (UA) from June 1981 to September 1982, 100 had persistent angina despite optimal medical therapy of nitrates, propranolol, and nifedipine. At catheterization, 70% of the refractory patients had left main (LM) or three-vessel disease (TVD), 68...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198410000-00007

    authors: Rankin JS,Newton JR Jr,Califf RM,Jones RH,Wechsler AS,Oldham HN Jr,Wolfe WG,Lowe JE

    更新日期:1984-10-01 00:00:00

  • Analysis of the First 217 Appendectomies of the German NOTES Registry.

    abstract:OBJECTIVE:To analyze the feasibility and safety of Natural Orifice Transluminal Endoscopic Surgery (NOTES) appendectomy, and to analyze separately the transvaginal appendectomy (TVAE) and the transgastric appendectomy (TGAE) procedures. BACKGROUND:Laparoscopic appendectomy has rare but relevant complications, namely i...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000001742

    authors: Bulian DR,Kaehler G,Magdeburg R,Butters M,Burghardt J,Albrecht R,Bernhardt J,Heiss MM,Buhr HJ,Lehmann KS

    更新日期:2017-03-01 00:00:00

  • Adenocarcinoma of the esophagus.

    abstract::Adenocarcinoma involving the distal esophagus usually is far advanced when the patient is first seen. Adenocarcinoma differs from squamous carcinoma of the esophagus since it is relatively unresponsive to radiation therapy or chemotherapy. Adenocarcinoma of the esophagus resembles gastric cancer in its tendency to for...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198705000-00015

    authors: Mahoney JL,Condon RE

    更新日期:1987-05-01 00:00:00

  • Laparoscopic adjustable silicone gastric banding versus vertical banded gastroplasty in morbidly obese patients: a prospective randomized controlled clinical trial.

    abstract:OBJECTIVE:To compare, in a prospective, randomized, single-institution trial laparoscopic adjustable silicone gastric banding (LASGB) with laparoscopic vertical banded gastroplasty (LVBG) in morbidly obese patients. SUMMARY BACKGROUND DATA:LASGB is a simple and safe procedure, but some reports have suggested disappoin...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.sla.0000098627.18574.72

    authors: Morino M,Toppino M,Bonnet G,del Genio G

    更新日期:2003-12-01 00:00:00

  • Methodological Quality of Surgical Mortality Studies Using Large Hospital Databases: A Systematic Review.

    abstract:OBJECTIVE:To review the methodology employed in surgical mortality studies to control for potential confounders. SUMMARY BACKGROUND DATA:Nationwide hospital data are increasingly used to investigate surgical outcomes. However, poor data granularity and coding inaccuracies may lead to flawed findings. METHODS:We condu...

    journal_title:Annals of surgery

    pub_type: 杂志文章,评审

    doi:10.1097/SLA.0000000000002119

    authors: Payet C,Lifante JC,Carty MJ,Rabilloud M,Duclos A

    更新日期:2017-06-01 00:00:00

  • Myocardial revascularization: a rebuttal of the cooperative study.

    abstract::From January 1972 through December 1974, at Saint Louis University Medical Center (SLU), 345 patients similar to those of the VA Cooperative Coronary Artery Study received CABG. Operative mortality was SLU 2.3%, VA 5.6% (p < 0.05). Perioperative myocardial infarction rate was SLU 8.4%, VA 18% (p < 0.005). One year gra...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197809000-00008

    authors: Kaiser GC,Barner HB,Tyras DH,Codd JE,Mudd JG,Willman VL

    更新日期:1978-09-01 00:00:00

  • Variation in practice and resource utilization associated with the diagnosis and management of appendicitis at freestanding children's hospitals: implications for value-based comparative analysis.

    abstract:OBJECTIVE:To characterize the scope and magnitude of practice variation associated with the diagnosis and treatment of appendicitis at freestanding children's hospitals. BACKGROUND:Variation in care has been associated with poor outcomes and is believed to be a key driver of excess health care spending. METHODS:Retro...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1097/SLA.0000000000000246

    authors: Rice-Townsend S,Barnes JN,Hall M,Baxter JL,Rangel SJ

    更新日期:2014-06-01 00:00:00

  • Pseudomonas aeruginosa expresses a lethal virulence determinant, the PA-I lectin/adhesin, in the intestinal tract of a stressed host: the role of epithelia cell contact and molecules of the Quorum Sensing Signaling System.

    abstract:OBJECTIVE:We have previously demonstrated that P. aeruginosa can have profound effects on the intestinal epithelial barrier via one of its virulence factors, the PA-I lectin/adhesin. The aims of the present study were to further characterize the interaction of P. aeruginosa and the intestinal epithelium using both in v...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094551.88143.f8

    authors: Wu L,Holbrook C,Zaborina O,Ploplys E,Rocha F,Pelham D,Chang E,Musch M,Alverdy J

    更新日期:2003-11-01 00:00:00

  • Computed tomographic angiography for the diagnosis of blunt carotid/vertebral artery injury: a note of caution.

    abstract:OBJECTIVE:Computed tomographic angiography (CTA) by 16-channel multidetector scanner is increasingly replacing conventional digital subtraction angiography (DSA) for diagnosing or excluding blunt carotid/vertebral injuries (BCVI). To date there has been only 1 study in which all patients received both examinations. Tha...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e3181568cab

    authors: Malhotra AK,Camacho M,Ivatury RR,Davis IC,Komorowski DJ,Leung DA,Grizzard JD,Aboutanos MB,Duane TM,Cockrell C,Wolfe LG,Borchers CT,Martin NR

    更新日期:2007-10-01 00:00:00

  • Gastrointestinal manifestations of multiple endocrine neoplasia type 2.

    abstract:OBJECTIVE:To determine the clinical features, natural history, and role of surgery for gastrointestinal manifestations of the multiple endocrine neoplasia type 2 (MEN 2) syndromes. SUMMARY BACKGROUND DATA:The MEN 2 syndromes are characterized by medullary thyroid carcinoma and other endocrinopathies. In addition, some...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200205000-00006

    authors: Cohen MS,Phay JE,Albinson C,DeBenedetti MK,Skinner MA,Lairmore TC,Doherty GM,Balfe DM,Wells SA Jr,Moley JF

    更新日期:2002-05-01 00:00:00

  • Cytology of peritoneal lavage performed during staging laparoscopy for gastrointestinal malignancies: is it useful?

    abstract:OBJECTIVE:To evaluate the potential benefit of cytology of the peritoneal lavage obtained during diagnostic laparoscopy for staging gastrointestinal (GI) malignancies. SUMMARY BACKGROUND DATA:Peritoneal lavage is a simple procedure that can be performed during laparotomy for GI tumors. Tumor cells in the lavage fluid ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199812000-00002

    authors: Nieveen van Dijkum EJ,Sturm PD,de Wit LT,Offerhaus J,Obertop H,Gouma DJ

    更新日期:1998-12-01 00:00:00

  • International Multicenter Study on the Impact of Extracapsular Lymph Node Involvement in Primary Surgery Adenocarcinoma of the Esophagus on Overall Survival and Staging Systems.

    abstract:OBJECTIVE:The current pathological lymph node (pN) staging is based on the number of positive lymph nodes but does not take into consideration characteristics of the involved lymph nodes itself. The current study aims to examine the prognostic value of extracapsular lymph node involvement (EC-LNI) and intracapsular lym...

    journal_title:Annals of surgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/SLA.0000000000001463

    authors: Nafteux PR,Lerut AM,Moons J,Hölscher AH,Bollschweiler E,van Berge Henegouwen MI,Lagarde SM,van Lanschot JJ,Messager M,Mariette C,D'Journo XB,Thomas PA,De Leyn PR

    更新日期:2015-11-01 00:00:00

  • Prophylactic revascularization of the gut.

    abstract::Reconstitution of the mesenteric vascular circulation, in our experience, is advisable when advanced occlusive disease is noted on the preoperative arteriogram of patients selected for aortoiliofemoral, renal artery, or aortic aneurysm surgery. A lateral aortogram is mandatory, and the presence of an anastomotic meand...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-197910000-00011

    authors: Connolly JE,Kwaan JH

    更新日期:1979-10-01 00:00:00

  • A randomized clinical trial of moxalactam alone versus tobramycin plus clindamycin in abdominal sepsis.

    abstract::One hundred patients with intraabdominal infections were assigned randomly in double-blind fashion to receive either the combination of tobramycin plus clindamycin (TM/C) or moxalactam (MOX) alone. Fifty patients comprised each group, but one patient in each group died of infection before 48 hours treatment. In the re...

    journal_title:Annals of surgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00000658-198307000-00007

    authors: Schentag JJ,Wels PB,Reitberg DP,Walczak P,Van Tyle JH,Lascola RJ

    更新日期:1983-07-01 00:00:00

  • Conversion of exocrine secretions from bladder to enteric drainage in recipients of whole pancreaticoduodenal transplants.

    abstract::Between September 1984 and August 1991, 265 whole pancreaticoduodenal transplants were done at our institution, with bladder drainage of exocrine secretions through a duodenocystostomy. Seventeen patients subsequently underwent conversion from bladder to enteric drainage at 2 to 64 months after transplant. Eight conve...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199212000-00008

    authors: Stephanian E,Gruessner RW,Brayman KL,Gores P,Dunn DL,Najarian JS,Sutherland DE

    更新日期:1992-12-01 00:00:00

  • Gastroesophageal reflux: prevalence in adults older than 28 years after correction of esophageal atresia.

    abstract:OBJECTIVE:To study the incidence of gastroesophageal reflux (GER)related complications after correction of esophageal atresia (EA). SUMMARY BACKGROUND DATA:The association of EA and GER in children is well known. However, little is known about the prevalence of GER and its potential complications in adults who have un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/01.sla.0000094303.07910.05

    authors: Deurloo JA,Ekkelkamp S,Bartelsman JF,Ten Kate FJ,Schoorl M,Heij HA,Aronson DC

    更新日期:2003-11-01 00:00:00

  • A Novel Method to Improve Perfusion of Ex Vivo Pumped Human Kidneys.

    abstract:OBJECTIVE:To determine if addition of the S-nitrosylating agent ethyl nitrite (ENO) to the preservation solution can improve perfusion parameters in pumped human kidneys. BACKGROUND:A significant percentage of actively stored kidneys experience elevations in resistance and decreases in flow rate during the ex vivo sto...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0000000000003702

    authors: Zhu L,Qureshi A,Awad M,Hausladen A,Perez-Protto S,Latifi SQ,Lebovitz DJ,Chavin K,Stamler JS,Reynolds JD

    更新日期:2019-12-05 00:00:00

  • Impairment of pulmonary macrophage function with total parenteral nutrition.

    abstract:OBJECTIVE:The effects of total parenteral nutrition (TPN) administration on pulmonary macrophage function and host response to gram-negative pulmonary infection were evaluated. SUMMARY BACKGROUND DATA:Administration of TPN resulted in increased infectious complications in traumatized and perioperative patients, but un...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-199403000-00009

    authors: Shou J,Lappin J,Daly JM

    更新日期:1994-03-01 00:00:00

  • Blood cardioplegia delivery. Deleterious effects of potassium versus lidocaine.

    abstract::Delivery of cardioplegic (CP) solutions to all regions of the myocardium is critical for optimal myocardial protection during cardiac surgery. However, there are little data regarding the effects of CP agents upon coronary vascular resistance (CVR) and CP delivery. Accordingly, we evaluated blood CP (Hct 30) delivery ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198309000-00003

    authors: Leicher FG,Magrassi P,LaRaia PJ,Derkac WM,Buckley MJ,Austen WG

    更新日期:1983-09-01 00:00:00

  • Post-traumatic parotid fistulae and sialoceles. A prospective study of conservative management in 51 cases.

    abstract::The management of parotid sialoceles and fistulae have been unsatisfactory in the past, and numerous methods of treatment with varying success and morbidity have been described. The present prospective study reports results of conservative therapy in 51 patients over a 3-year period. In 50 patients, the injury healed ...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198901000-00015

    authors: Parekh D,Glezerson G,Stewart M,Esser J,Lawson HH

    更新日期:1989-01-01 00:00:00

  • Popliteal artery puncture in the assessment of patients with severe leg ischemia.

    abstract::Two-plane angiography and direct segmental pressure measurements in the femoral and popliteal arteries and indirectly on the arm and ankle were performed in 101 limbs seeking to establish a relationship between angiographic assessment of the patency of the popliteal artery and the trifurcation vessels and the poplitea...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-198312000-00017

    authors: Agerskov K,Faris I,Tønnesen KH,Kristensen P,Christensen SC

    更新日期:1983-12-01 00:00:00

  • Perineural invasion and lymph node involvement as indicators of surgical outcome and pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy for resectable pancreatic cancer.

    abstract:OBJECTIVE:To analyze the histopathological indicators significantly associated with surgical outcome and the pattern of recurrence in the setting of preoperative gemcitabine-based chemoradiation therapy (CRT) and subsequent pancreatectomy. BACKGROUND:Clinicopathological assessment of the resected specimen is an indisp...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/SLA.0b013e31823d813c

    authors: Takahashi H,Ohigashi H,Ishikawa O,Gotoh K,Yamada T,Nagata S,Tomita Y,Eguchi H,Doki Y,Yano M

    更新日期:2012-01-01 00:00:00

  • Logistics and technique for procurement of intestinal, pancreatic, and hepatic grafts from the same donor.

    abstract:OBJECTIVE:To assess a technique for simultaneous recovery of the intestine, pancreas, and liver from the same donor. SUMMARY BACKGROUND DATA:With the more frequent use of pancreatic and intestinal transplantation, a procurement procedure is needed that permits retrieval of both organs as well as the liver from the sam...

    journal_title:Annals of surgery

    pub_type: 杂志文章

    doi:10.1097/00000658-200011000-00010

    authors: Abu-Elmagd K,Fung J,Bueno J,Martin D,Madariaga JR,Mazariegos G,Bond G,Molmenti E,Corry RJ,Starzl TE,Reyes J

    更新日期:2000-11-01 00:00:00