Identification of a degradation product in stressed tablets of olmesartan medoxomil by the complementary use of HPLC hyphenated techniques.

abstract：:This review paper discusses the success of columns packed with superficially porous particles (SPP) in liquid chromatography for the analysis of peptides and proteins. First, it summarizes the history of SPP, including the development of different SPP generations from particles of 50 μm to sub-2 μm. It also critically...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bobály B,Veuthey JL,Guillarme D,Fekete S

更新日期：2018-09-05 00:00:00

abstract：:A simple, rapid and sensitive isocratic reversed phase HPLC method with UV detection using internal standard has been developed and validated for simultaneous determination of amoxicillin and clavulanic acid in human plasma. The assay enables the measurement of amoxicillin and clavulanic acid for therapeutic drug moni...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Foroutan SM,Zarghi A,Shafaati A,Khoddam A,Movahed H

更新日期：2007-11-05 00:00:00

abstract：:Cimetidine has been determined in the presence of its acid-induced degradation products using a second derivative (D2-) spectrophotometric method (method I) or a colorimetric method (method II). The former is based on D2-value measurement at 216 nm, whilst the latter depends on charge-transfer complexation with dichlo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bedair MM,Elsayed MA,Korany MA,Fahmy OT

更新日期：1991-01-01 00:00:00

abstract：:In traditional Chinese medicine practice, crude herbs are often subjected to traditional processing (Paozhi in Chinese) for a special medicinal purpose. Bran-frying is one of processing methods for Paeoniae Radix Alba (PRA). Previous studies found that paeoniflorin and paeoniflorin sulfonate, a principle bioactive com...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Xu YY,Long F,Zhang YQ,Xu JD,Kong M,Li SL

更新日期：2018-09-10 00:00:00

abstract：:Platycladi Cacumen (PC) is a traditional Chinese medicine used for the treatment of hemorrhages, cough, asthma and hair loss. To get a better understanding of the chemical constituents in PC, ultra-high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectro...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zhuang B,Bi ZM,Wang ZY,Duan L,Lai CJ,Liu EH

更新日期：2018-05-30 00:00:00

abstract：:An electroanalytical study of the oxidation of Novalgin (dipyrone) at a glassy carbon electrode in aqueous solution has been carried out. A flow-injection method with amperometric detection based on this oxidation process is also described. The influence of flow rate, coil length and injection volume on the sensitivit...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Pérez-Ruiz T,Martínez Lozano C,Tomás V

更新日期：1994-09-01 00:00:00

abstract：:Sunitinib malate, an oral multi-targeted tyrosine kinase inhibitor approved for the treatment of metastatic renal cell carcinoma, gastrointestinal stromal tumor, and well-differentiated pancreatic neuroendocrine tumors, has been identified as a potential candidate for therapeutic drug monitoring approach. Nevertheless...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Posocco B,Buzzo M,Giodini L,Crotti S,D'Aronco S,Traldi P,Agostini M,Marangon E,Toffoli G

更新日期：2018-10-25 00:00:00

abstract：:A dissolution method with high performance liquid chromatography (HPLC) analysis was validated for an immediate release low dose tablet formulation. The method was validated to meet requirements for a global regulatory filing and this validation included specificity, precision, linearity, accuracy and range. Validatio...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Space JS,Opio AM,Nickerson B,Jiang H,Dumont M,Berry M

更新日期：2007-09-03 00:00:00

abstract：:Camazepam [3-(N,N-dimethyl)carbamoyloxy-7-chloro-1-methyl-1, 3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one, CMZ] possesses anxiolytic, anticonvulsant, muscle relaxant and hypnotic properties. CMZ is clinically used as a racemate. The enantioselective metabolism of racemic CMZ by rat liver microsomes was studied. Major...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Lu XL,Yang SK

更新日期：1993-11-01 00:00:00

abstract：:In this paper, we review recent research articles on liquid-phase microextraction of drug substances from biological fluids, such as plasma, serum, urine, and saliva. We focus on papers where liquid-phase microextraction is combined with liquid chromatography coupled with mass spectrometry (LC-MS), published in the pe...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hansen F,Øiestad EL,Pedersen-Bjergaard S

更新日期：2020-09-10 00:00:00

abstract：:The purpose of this work was to demonstrate the possibilities offered by laser-induced breakdown spectroscopy (LIBS) for the direct and rapid analysis of pharmaceutical liquid formulations. Sodium chloride in solution was chosen as a model compound. A pulsed Nd:YAG laser (1064 nm) was used to produce a gaseous plasma ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： St-Onge L,Kwong E,Sabsabi M,Vadas EB

更新日期：2004-10-29 00:00:00

abstract：:A simple, selective and sensitive method has been developed to determine debrisoquine and 4-hydroxydebrisoquine in human urine. Separation of the analytes was obtained using a mobile phase of 0.1 M sodium dihydrogen phosphate-acetonitrile (87:13, v/v) and a muBondapak C18 column. The column effluent was monitored with...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bozkurt A,Basci NE,Isimer A,Kayaalp SO

更新日期：1993-08-01 00:00:00

abstract：:As the global market for pharmaceuticals increases, the adverse consequences of different regulations and requirements are becoming more obvious. Discussions between the regulatory authorities for the European Community, United States and Japan under the International Conference on Harmonization (ICH) intended to remo...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Calam DH

更新日期：1995-12-01 00:00:00

abstract：:Assessing the physical state of a low-dose active compound in a solid lipid or polymer matrix is analytically challenging, especially if the matrix exhibits some crystallinity. The aim of this study was first to compare the ability of current methods to detect the presence of a crystalline model compound in lipid matr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Adler C,Schönenberger M,Teleki A,Leuenberger B,Kuentz M

更新日期：2015-11-10 00:00:00

abstract：:Botulinum type A toxin (BoNT/A) is defined by its specific endopeptidase cleavage of SNAP25 between Gln(197) and Arg(198) under reducing conditions. The neurotoxin is widely used for therapeutic or cosmetic purposes, but should not contain other toxin serotypes or unwanted protease activities. Using a neoepitope endop...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Jones RG,Liu Y,Halls C,Thorpe SJ,Longstaff C,Matejtschuk P,Sesardic D

更新日期：2011-01-05 00:00:00

abstract：:The lipophilicity of a compound is a fundamental property related to pharmaceutical and biomedical activity. As many approaches are mixed together in every-day published studies, the subject needs some standardization. The paper presents a comparative study on several approaches of TLC lipophilicity determination: a s...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Komsta Ł,Skibiński R,Berecka A,Gumieniczek A,Radkiewicz B,Radoń M

更新日期：2010-12-01 00:00:00

abstract：:A simple high-performance liquid chromatographic method was developed to study the pharmacokinetics of osthole in rat plasma. After addition of an internal standard (paeonol), plasma was deproteinized by acetonitrile for sample clean-up. The drugs were separated on a reversed-phase column and detected by UV absorption...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Tsai TH,Tsai TR,Chen CC,Chen CF

更新日期：1996-04-01 00:00:00

abstract：:In this study, a improved high performance liquid chromatography-diode array detector (HPLC-DAD) method for simultaneous quantification of twelve major components belonging to three chemical types was developed and validated, and was applied to quantitatively compare the quality of Radix Paeoniae Alba (RPA) sulfur-fum...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kong M,Liu HH,Xu J,Wang CR,Lu M,Wang XN,Li YB,Li SL

更新日期：2014-09-01 00:00:00

abstract：:A stability-indicating reversed-phase liquid chromatography (LC) method was developed and validated for the determination of lumiracoxib in pharmaceutical formulations. The LC method was carried out on a Synergi fusion C(18) column (150 mmx4.6mm), maintained at 30 degrees C. The mobile phase was composed of phosphoric...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Oliveira PR,Bernardi LS,Mendes C,Sangoi MS,Silva MA

更新日期：2010-02-05 00:00:00

abstract：:PtCuCo trimetallic alloys (PtCuCo-TAs) are synthesized by one-step reduction. The chemiluminescence (CL) properties of PtCuCo-TAs are studied systemically. PtCuCo-TAs show good catalyzing for luminol-H2O2 system. A CL platform is developed for the detection of miRNA-21 using PtCuCo-TAs as nanozyme catalyzer. In the CL...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Mei S,Liu B,Xiong X,Hun X

更新日期：2020-07-15 00:00:00

abstract：:Fluoxetine hydrochloride has been prepared using two similar synthetic routes, both of which rely upon an ether formation reaction mediated by a base. The base used can affect the impurity profile of this reaction. It was proposed that the synthesis of fluoxetine carried out using potassium t-butoxide as base and 4-ch...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Robbins DK,Dodson PN,Buccilli LA,Mitchell D

更新日期：2003-02-05 00:00:00

abstract：:A System Suitability Test (SST) is a test to verify the adequate working of the equipment used for analytical measurements. In pharmaceutical analysis, SSTs are performed at least at the beginning of a series of routine analyses. The most generally applied SST considers the precision of the analysis, i.e. the repeatab...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Hund E,Vander Heyden Y,Massart DL,Smeyers-Verbeke J

更新日期：2002-11-07 00:00:00

abstract：:In recent years, amorphous formulations and other special dosage forms of drug products have been investigated to achieve adequate solubility and disintegration. We have evaluated the distribution of crystalline and amorphous states of a drug product using Nanothermal analysis (Nano-TA) and Raman imaging methods. Comp...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Nakamoto K,Urasaki T,Hondo S,Murahashi N,Yonemochi E,Terada K

更新日期：2013-03-05 00:00:00

abstract：:A sensitive liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the determination of adenosine concentrations in mouse brain microdialysis samples was developed. High method sensitivity (LLOQ of 1.25 fmol) was achieved by on-line switching column. A C18 was employed as enrichment column and a cyano ba...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Carrozzo MM,Troisi L,Cannazza G,Cazzato AS,Braghiroli D,Parenti C,Guiducci S,Zoli M

更新日期：2012-11-01 00:00:00

abstract：:A method is described for analysis of the tetracycline antibiotic minocycline using capillary zone electrophoresis. Potential impurities are 4-epiminocycline, 6-deoxy-6-demethyltetracycline, 7-didemethylminocycline, 7-monodemethylminocycline and 9-minocycline. Method development was undertaken with a mixture consistin...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Li YM,Van Schepdael A,Roets E,Hoogmartens J

更新日期：1996-06-01 00:00:00

abstract：:The current study dealt with the degradation behavior of lacosamide (LAC) under ICH prescribed stress conditions. LAC was found to be labile under acid and base hydrolytic stress conditions, while it was stable to neutral hydrolytic, oxidative, photolytic and thermal stress. In total, seven degradation products (DPs) ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ramisetti NR,Kuntamukkala R,Lakshetti S,Sripadi P

更新日期：2014-07-01 00:00:00

abstract：:The chromatographic behaviour (retention, selectivity, peak shape and resolution) of seven tricyclic antidepressants (TCAs), amitryptiline, clomipramine, doxepin, imipramine, maprotiline, nortryptiline and trimipramine, was examined. Conventional unendcapped Cs and C18 columns and an endcapped XTerra MS C18 column rec...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ruiz-Angel MJ,Carda-Broch S,Simó-Alfonso EF,García-Alvarez-Coque MC

更新日期：2003-04-24 00:00:00

abstract：:The mixture of creatinine, activated charcoal and water was stirred. As a result the conversion of creatinine into two products was observed. (1)H, (13)C NMR and HMBC spectra were recorded and the chemical shifts assigned. Two uremic toxins: creatol and N-methylguanidine were identified. To interpret the NMR data obta...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Krawczyk H

更新日期：2009-05-01 00:00:00

abstract：:A reversed-phase high performance liquid chromatographic (LC), tandem mass spectrometry (MS/MS) assay for the determination of tenofovir (TFV) and emtricitabine (FTC) in dried blood spots (DBS) from human whole blood was developed and validated. Whole blood samples were spotted, dried, and a 3mm punch was extracted wi...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Zheng JH,Guida LA,Rower C,Castillo-Mancilla J,Meditz A,Klein B,Kerr BJ,Langness J,Bushman L,Kiser J,Anderson PL

更新日期：2014-01-01 00:00:00

abstract：:The relationship between a reversed-phase high-performance liquid chromatography (RP-HPLC) retention parameter and various calculated log P-values of our previously synthesized alpha-aryl-N-cyclopropyl-nitrone derivatives was investigated. The RP-HPLC experiments were carried out with acetonitrile-water and methanol-w...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Balogh GT,Szántó Z,Forrai E,Gyorffy W,Lopata A

更新日期：2005-10-04 00:00:00