Regulation of CDC9, the Saccharomyces cerevisiae gene that encodes DNA ligase.

abstract：:GIPC is a PDZ protein located on peripheral endosomes that binds to the juxtamembrane region of the TrkA nerve growth factor (NGF) receptor and has been implicated in NGF signaling. We establish here that endogenous GIPC binds to the C terminus of APPL, a Rab5 binding protein, which is a marker for signaling endosomes...

journal_title：Molecular and cellular biology

authors： Varsano T,Dong MQ,Niesman I,Gacula H,Lou X,Ma T,Testa JR,Yates JR 3rd,Farquhar MG

更新日期：2006-12-01 00:00:00

abstract：:Mos is a germ cell-specific serine/threonine protein kinase that activates mitogen-activated protein kinase (MAPK) through MAPK kinase (MKK). In Xenopus oocytes, Mos synthesis is required for progesterone-induced activation of MAPK and maturation promoting factor. Injection of Mos or active MAPK causes mitotic arrest ...

journal_title：Molecular and cellular biology

authors： Chen M,Cooper JA

更新日期：1995-09-01 00:00:00

abstract：:We have shown previously that perturbation of origin firing in chromosome replication causes DNA lesions and triggers DNA damage checkpoint control, which ensures genomic integrity by stopping cell cycle progression until the lesions are repaired or by inducing cell death if they are not properly repaired. This was ba...

journal_title：Molecular and cellular biology

authors： Ide S,Watanabe K,Watanabe H,Shirahige K,Kobayashi T,Maki H

更新日期：2007-01-01 00:00:00

abstract：:Regulatory regions of the mouse muscle creatine kinase (MCK) gene, previously discovered by analysis in cultured muscle cells, were analyzed in transgenic mice. The 206-bp MCK enhancer at nt-1256 was required for high-level expression of MCK-chloramphenicol acetyltransferase fusion genes in skeletal and cardiac muscle...

journal_title：Molecular and cellular biology

authors： Donoviel DB,Shield MA,Buskin JN,Haugen HS,Clegg CH,Hauschka SD

更新日期：1996-04-01 00:00:00

abstract：:The differentiation of dental epithelia into enamel-producing ameloblasts or the root epithelial lineage compartmentalizes teeth into crowns and roots. Bmp signaling has been linked to enamel formation, but its role in root epithelial lineage differentiation is unclear. Here we show that cessation of epithelial Bmp si...

journal_title：Molecular and cellular biology

authors： Yang Z,Hai B,Qin L,Ti X,Shangguan L,Zhao Y,Wiggins L,Liu Y,Feng JQ,Chang JY,Wang F,Liu F

更新日期：2013-12-01 00:00:00

abstract：:Retinoblastoma (RB) tumors develop when both alleles of a gene (RB1) are mutated and unable to function normally. Recently, Friend et al. [S. H. Friend, R. Bernards, S. Rogelj, R. A. Weinberg, J. M. Rapaport, D. M. Albert, and T. P. Dryja, Nature (London) 32:643-646, 1986] reported the cloning of a gene, 4.7R, with so...

journal_title：Molecular and cellular biology

authors： Goddard AD,Balakier H,Canton M,Dunn J,Squire J,Reyes E,Becker A,Phillips RA,Gallie BL

更新日期：1988-05-01 00:00:00

abstract：:NF-kappaB activation is reciprocally regulated by RelA/p65 acetylation and deacetylation, which are mediated by histone acetyltransferases (HATs) and deacetylases (HDACs). Here we demonstrate that in leukemia cells, NF-kappaB activation by the HDAC inhibitors (HDACIs) MS-275 and suberoylanilide hydroxamic acid was ass...

journal_title：Molecular and cellular biology

authors： Dai Y,Rahmani M,Dent P,Grant S

更新日期：2005-07-01 00:00:00

abstract：:In Saccharomyces cerevisiae, the protein phosphatase type 1 (PP1)-binding protein Reg1 is required to maintain complete repression of ADH2 expression during growth on glucose. Surprisingly, however, mutant forms of the yeast PP1 homologue Glc7, which are unable to repress expression of another glucose-regulated gene, ...

journal_title：Molecular and cellular biology

authors： Dombek KM,Voronkova V,Raney A,Young ET

更新日期：1999-09-01 00:00:00

abstract：:Although largely involved in innate and adaptive immunity, NF-kappa B plays an important role in vertebrate development. In chicks, the inactivation of the NF-kappa B pathway induces functional alterations of the apical ectodermal ridge, which mediates limb outgrowth. In mice, the complete absence of NF-kappa B activi...

journal_title：Molecular and cellular biology

authors： Correa RG,Tergaonkar V,Ng JK,Dubova I,Izpisua-Belmonte JC,Verma IM

更新日期：2004-06-01 00:00:00

abstract：:Phosphatidylinositol (PI) 3-kinase is a cytoplasmic signaling molecule recruited to the membrane by activated growth factor receptors. The p85 subunit of PI 3-kinase links the catalytic p110 subunit to activated growth factor receptors and is required for enzymatic activity of p110. In this report, we describe the eff...

journal_title：Molecular and cellular biology

authors： Klippel A,Reinhard C,Kavanaugh WM,Apell G,Escobedo MA,Williams LT

更新日期：1996-08-01 00:00:00

abstract：:Numerous nonribosomal trans-acting factors involved in pre-rRNA processing have been characterized, but few of them are specifically required for the last cytoplasmic steps of 18S rRNA maturation. We have recently demonstrated that Rrp10p/Rio1p is such a factor. By BLAST analysis, we identified the product of a previo...

journal_title：Molecular and cellular biology

authors： Vanrobays E,Gelugne JP,Gleizes PE,Caizergues-Ferrer M

更新日期：2003-03-01 00:00:00

abstract：:Protein ubiquitination provides an efficient and reversible mechanism to regulate cell cycle progression and checkpoint control. Numerous regulatory proteins direct the addition of ubiquitin to lysine residues on target proteins, and these are countered by an army of deubiquitinating enzymes (DUBs). BRCA1-associated p...

journal_title：Molecular and cellular biology

authors： Misaghi S,Ottosen S,Izrael-Tomasevic A,Arnott D,Lamkanfi M,Lee J,Liu J,O'Rourke K,Dixit VM,Wilson AC

更新日期：2009-04-01 00:00:00

abstract：:CD133, a widely known marker of cancer stem cells, was recently found in extracellular vesicles. However, the mechanisms underlying CD133 translocation to the extracellular space remain largely unknown. Here we report that CD133 is monoubiquitinated. Ubiquitination occurs primarily on complex glycosylated CD133. The l...

journal_title：Molecular and cellular biology

authors： Yang F,Xing Y,Li Y,Chen X,Jiang J,Ai Z,Wei Y

更新日期：2018-07-16 00:00:00

abstract：:The Neurospora crassa arg-2 upstream open reading frame (uORF) plays a role in negative arginine-specific translational regulation. Primer extension inhibition analyses of arg-2 uORF-containing RNA translated in a cell-free system in which arginine-specific regulation was retained revealed "toeprints" corresponding to...

journal_title：Molecular and cellular biology

authors： Wang Z,Sachs MS

更新日期：1997-09-01 00:00:00

abstract：:ARGRI, ARGRII, and ARGRIII proteins regulate the expression of arginine anabolic and catabolic genes. The integrity of these three proteins is required to observe the formation of a DNA-protein complex with the different promoters of arginine coregulated genes. A study of deletions and point mutations created in the 5...

journal_title：Molecular and cellular biology

authors： Messenguy F,Dubois E,Boonchird C

更新日期：1991-05-01 00:00:00

abstract：:The Drosophila melanogaster GAGA factor (encoded by the Trithorax-like [Trl] gene) is required for correct chromatin architecture at diverse chromosomal sites. The Trl gene encodes two alternatively spliced isoforms of the GAGA factor (GAGA-519 and GAGA-581) that are identical except for the length and sequence of the...

journal_title：Molecular and cellular biology

authors： Greenberg AJ,Schedl P

更新日期：2001-12-01 00:00:00

abstract：:Menin, the product of the multiple endocrine neoplasia type I gene, has been implicated in several biological processes, including the control of gene expression and apoptosis, the modulation of mitogen-activated protein kinase pathways, and DNA damage sensing or repair. In this study, we have investigated the functio...

journal_title：Molecular and cellular biology

authors： Papaconstantinou M,Wu Y,Pretorius HN,Singh N,Gianfelice G,Tanguay RM,Campos AR,Bédard PA

更新日期：2005-11-01 00:00:00

abstract：:Cell cycle arrests in the G(1), S, and G(2) phases occur in mammalian cells after ionizing irradiation and appear to protect cells from permanent genetic damage and transformation. Though Brca1 clearly participates in cellular responses to ionizing radiation (IR), conflicting conclusions have been drawn about whether ...

journal_title：Molecular and cellular biology

authors： Xu B,Kim St,Kastan MB

更新日期：2001-05-01 00:00:00

abstract：:There are three mechanisms of transcriptional repression in eukaryotes. The first is quenching, whereby repressors and activators co-occupy closely linked sites and then the repressor inhibits adjacent activators. The second is direct repression, in which repressors block the function of the core transcription complex...

journal_title：Molecular and cellular biology

authors： Nibu Y,Senger K,Levine M

更新日期：2003-06-01 00:00:00

abstract：:Transcriptional insulators are cis regulatory elements that organize chromatin into independently regulated domains. At the imprinted murine Igf2/H19 locus, the H19-ICR insulator prevents the activation of the Igf2 promoter on the maternal allele by enhancers that activate H19 on the same chromosome. Given the well-de...

journal_title：Molecular and cellular biology

authors： Singh V,Srivastava M

更新日期：2008-06-01 00:00:00

abstract：:Phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha) is typically associated with stress responses and causes a reduction in protein synthesis. However, we found high phosphorylated eIF-2 alpha (eIF-2 alpha[P]) levels in nonstressed pancreata of mice. Administration of glucose stimulated a rapid depho...

journal_title：Molecular and cellular biology

authors： Zhang P,McGrath B,Li S,Frank A,Zambito F,Reinert J,Gannon M,Ma K,McNaughton K,Cavener DR

更新日期：2002-06-01 00:00:00

abstract：:It is well established that cell survival signals stimulated by growth factors, cytokines, and oncoproteins are initiated by phosphoinositide 3-kinase (PI3K)- and Akt-dependent signal transduction pathways. Oncogenic Ras, an upstream activator of Akt, requires NF-kappaB to initiate transformation, at least partially t...

journal_title：Molecular and cellular biology

authors： Madrid LV,Wang CY,Guttridge DC,Schottelius AJ,Baldwin AS Jr,Mayo MW

更新日期：2000-03-01 00:00:00

abstract：:V(D)J recombination requires binding and synapsis of a complementary (12/23) pair of recombination signal sequences (RSSs) by the RAG1 and RAG2 proteins, aided by a high-mobility group protein, HMG1 or HMG2. Double-strand DNA cleavage within this synaptic, or paired, complex is thought to involve DNA distortion or mel...

journal_title：Molecular and cellular biology

authors： Ciubotaru M,Schatz DG

更新日期：2004-10-01 00:00:00

abstract：:Nearly 40% of cases of acute myelogenous leukemia (AML) of the M2 subtype are due to a chromosomal translocation that combines a sequence-specific DNA binding protein, AML1, with a potent transcriptional repressor, ETO. ETO interacts with nuclear receptor corepressors SMRT and N-CoR, which recruit histone deacetylase ...

journal_title：Molecular and cellular biology

authors： Zhang J,Hug BA,Huang EY,Chen CW,Gelmetti V,Maccarana M,Minucci S,Pelicci PG,Lazar MA

更新日期：2001-01-01 00:00:00

abstract：:Dyskerin binds the H/ACA box of human telomerase RNA and is a core telomerase subunit required for RNP biogenesis and enzyme function in vivo. Missense mutations in dyskerin result in dyskeratosis congenita, a complex syndrome characterized by bone marrow failure, telomerase enzyme deficiency, and progressive telomere...

journal_title：Molecular and cellular biology

authors： Kannan K,Nelson AD,Shippen DE

更新日期：2008-04-01 00:00:00

abstract：:The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell line was derived from the...

journal_title：Molecular and cellular biology

authors： Johnson P,Chung S,Benchimol S

更新日期：1993-03-01 00:00:00

abstract：:The retinoblastoma protein (Rb) regulates both the cell cycle and tissue-specific transcription, by modulating the activity of factors that associate with its A-B and C pockets. In skeletal muscle, Rb has been reported to regulate irreversible cell cycle exit and muscle-specific transcription. To identify factors inte...

journal_title：Molecular and cellular biology

authors： MacLellan WR,Xiao G,Abdellatif M,Schneider MD

更新日期：2000-12-01 00:00:00

abstract：:GCN4 is a transcriptional activator of amino acid-biosynthetic genes in the yeast Saccharomyces cerevisiae. GCN2, a translational activator of GCN4 expression, contains a domain homologous to the catalytic subunit of eucaryotic protein kinases. Substitution of a highly conserved lysine residue in the kinase domain abo...

journal_title：Molecular and cellular biology

authors： Wek RC,Ramirez M,Jackson BM,Hinnebusch AG

更新日期：1990-06-01 00:00:00

abstract：:The Sry-related high-mobility-group box transcription factor Sox9 recruits the redundant L-Sox5 and Sox6 proteins to effect chondrogenesis, but the mode of action of the trio remains unclear. We identify here a highly conserved 359-bp sequence 10 kb upstream of the Agc1 gene for aggrecan, a most essential cartilage pr...

journal_title：Molecular and cellular biology

authors： Han Y,Lefebvre V

更新日期：2008-08-01 00:00:00

abstract：:We have developed a system to study mutations that affect xanthine-guanine phosphoribosyltransferase gene (gpt) expression in hypoxanthine-guanine phosphoribosyltransferase-deficient CHO cells that have been transformed by the plasmid vector pSV2gpt. One isolated transformant, designated AS52, carries a single copy of...

journal_title：Molecular and cellular biology

authors： Tindall KR,Stankowski LF Jr,Machanoff R,Hsie AW

更新日期：1984-07-01 00:00:00