CtBP-independent repression in the Drosophila embryo.

abstract：:clk-1 encodes a demethoxyubiquinone (DMQ) hydroxylase that is necessary for ubiquinone biosynthesis. When Caenorhabditis elegans clk-1 mutants are grown on bacteria that synthesize ubiquinone (UQ), they are viable but have a pleiotropic phenotype that includes slowed development, behaviors, and aging. However, when gr...

journal_title：Molecular and cellular biology

authors： Branicky R,Nguyen PA,Hekimi S

更新日期：2006-05-01 00:00:00

abstract：:The multienzyme complex prolyl 4-hydroxylase catalyzes the hydroxylation of proline residues and acts as a chaperone during collagen synthesis in multicellular organisms. The beta subunit of this complex is identical to protein disulfide isomerase (PDI). The free-living nematode Caenorhabditis elegans is encased in a ...

journal_title：Molecular and cellular biology

authors： Winter AD,Page AP

更新日期：2000-06-01 00:00:00

abstract：:3'-end processing of nucleus-encoded mRNAs includes the addition of a poly(A) tail that is important for translation initiation. Since the vast majority of chloroplast mRNAs acquire their 3' termini by processing yet are not polyadenylated, we asked whether 3' end maturation plays a role in chloroplast translation. A ...

journal_title：Molecular and cellular biology

authors： Rott R,Levy H,Drager RG,Stern DB,Schuster G

更新日期：1998-08-01 00:00:00

abstract：:In the early phase of bone damage, low concentrations of the cytokine tumor necrosis factor alpha (TNF-α) favor osteoblast differentiation. In contrast, chronic high doses of the same cytokine contribute to bone loss, demonstrating opposite effects depending on its concentration and on the time of exposure. In the bon...

journal_title：Molecular and cellular biology

authors： Daniele S,Natali L,Giacomelli C,Campiglia P,Novellino E,Martini C,Trincavelli ML

更新日期：2017-03-31 00:00:00

abstract：:The myeloperoxidase (MPO) and neutrophil elastase genes are expressed specifically in immature myeloid cells. The integrity of a polyomavirus enhancer core sequence, 5'-AACCACA-3', is critical to the activity of the murine MPO proximal enhancer. This element binds two species, myeloid nuclear factors 1 alpha and 1 bet...

journal_title：Molecular and cellular biology

authors： Nuchprayoon I,Meyers S,Scott LM,Suzow J,Hiebert S,Friedman AD

更新日期：1994-08-01 00:00:00

abstract：:Methylation of histone H3 on lysine 9 or 27 is crucial for heterochromatin formation. Previously considered hallmarks of, respectively, constitutive and facultative heterochromatin, recent evidence has accumulated in favor of coexistence of these two marks and their cooperation in gene silencing maintenance. H3K9me2/3...

journal_title：Molecular and cellular biology

authors： Boros J,Arnoult N,Stroobant V,Collet JF,Decottignies A

更新日期：2014-10-01 00:00:00

abstract：:We have identified stable transcripts from the so-called nontranscribed spacer region (NTS) of the nuclear ribosomal DNA repeat in certain respiration-deficient strains of Saccharomyces cerevisiae. These RNAs, which are transcribed from the same strand as is the 37S rRNA precursor, are 500 to 800 nucleotides long and ...

journal_title：Molecular and cellular biology

authors： Parikh VS,Conrad-Webb H,Docherty R,Butow RA

更新日期：1989-05-01 00:00:00

abstract：:The highly conserved SR family contains a growing number of phosphoproteins acting as both essential and alternative splicing factors. In this study, we have cloned human genomic and cDNA sequences encoding a novel SR protein designated SRp46. Nucleotide sequence analyses have revealed that the SRp46 gene corresponds ...

journal_title：Molecular and cellular biology

authors： Soret J,Gattoni R,Guyon C,Sureau A,Popielarz M,Le Rouzic E,Dumon S,Apiou F,Dutrillaux B,Voss H,Ansorge W,Stévenin J,Perbal B

更新日期：1998-08-01 00:00:00

abstract：:How early- and late-firing origins are selected on eukaryotic chromosomes is largely unknown. Here, we show that Mrc1, a conserved factor required for stabilization of stalled replication forks, selectively binds to the early-firing origins in a manner independent of Cdc45 and Hsk1 kinase in the fission yeast Schizosa...

journal_title：Molecular and cellular biology

authors： Hayano M,Kanoh Y,Matsumoto S,Masai H

更新日期：2011-06-01 00:00:00

abstract：:Transthyretin (TTR) and alpha 1-antitrypsin (alpha 1-AT) are expressed at high levels in the liver and also in at least one other cell type. We report here a detailed analysis of the proximal regulatory region of the TTR gene, which has uncovered two new DNA-binding factors that are present mainly (or only) in hepatoc...

journal_title：Molecular and cellular biology

authors： Costa RH,Grayson DR,Darnell JE Jr

更新日期：1989-04-01 00:00:00

abstract：:The adapter protein SH2-B has been shown to bind to activated nerve growth factor (NGF) receptor TrkA and has been implicated in NGF-induced neuronal differentiation and the survival of sympathetic neurons. However, the mechanism by which SH2-B enhances and maintains neurite outgrowth is unclear. We examined the abili...

journal_title：Molecular and cellular biology

authors： Chen L,Carter-Su C

更新日期：2004-05-01 00:00:00

abstract：:Multiple isoforms of the protein tyrosine phosphatase CD45 are expressed on the surface of human T cells. Interestingly, the expression of these isoforms has been shown to vary significantly upon T-cell activation. In this report, we describe a novel cell line-based model system in which we can mimic the activation-in...

journal_title：Molecular and cellular biology

authors： Lynch KW,Weiss A

更新日期：2000-01-01 00:00:00

abstract：:Two mutator genes of mammalian cells were demonstrated. One was associated with the ribonucleoside diphosphate reductase, and the other was associated with an extreme adenosine sensitivity. ...

journal_title：Molecular and cellular biology

authors： Chan VL,Guttman S,Juranka P

更新日期：1981-06-01 00:00:00

abstract：:Circadian clocks keep time via gene expression feedback loops that are controlled by time-of-day-specific changes in the synthesis, activity, and degradation of transcription factors. Within the Drosophila melanogaster circadian clock, DOUBLETIME (DBT) kinase is necessary for the phosphorylation of PERIOD (PER), a tra...

journal_title：Molecular and cellular biology

authors： Yu W,Zheng H,Price JL,Hardin PE

更新日期：2009-03-01 00:00:00

abstract：:Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell proliferation, cell differentiation, and cell migration. Some of these physiological responses are regulated via activation of transcription factors such as activator protein 1 (AP-1). Integrin-linked kinas...

journal_title：Molecular and cellular biology

authors： Troussard AA,Tan C,Yoganathan TN,Dedhar S

更新日期：1999-11-01 00:00:00

abstract：:Abelson murine leukemia virus (A-MuLV), a retrovirus that expresses the v-abl oncogene, characteristically induces pre-B-cell lymphomas following in vivo infection of BALB/c mice or in vitro infection of suspensions of fetal liver or bone marrow cells. ABL-MYC, a retrovirus that expresses both v-abl and c-myc, induces...

journal_title：Molecular and cellular biology

authors： Weissinger EM,Mischak H,Goodnight J,Davidson WF,Mushinski JF

更新日期：1993-04-01 00:00:00

abstract：:The class II transactivator (CIITA) is induced by gamma interferon (IFN-gamma) and activates major histocompatibility complex class II; however, this report shows it suppresses other genes. An N-terminal 36 amino acids of CIITA mediates suppression of the collagen alpha(2)(I) promoter via binding to CREB-binding prote...

journal_title：Molecular and cellular biology

authors： Zhu XS,Ting JP

更新日期：2001-10-01 00:00:00

abstract：:Activins and other members of the transforming growth factor beta family play a critical role in morphological changes of the epidermis that require epithelial cell movement. We investigated the molecular pathways in the transmission of activin signals that lead to actin reorganization and epithelial cell migration. W...

journal_title：Molecular and cellular biology

authors： Zhang L,Deng M,Parthasarathy R,Wang L,Mongan M,Molkentin JD,Zheng Y,Xia Y

更新日期：2005-01-01 00:00:00

abstract：:Recent research has identified critical roles for microRNAs in a large number of cellular processes, including tumorigenic transformation. While significant progress has been made towards understanding the mechanisms of gene regulation by microRNAs, much less is known about factors affecting the expression of these no...

journal_title：Molecular and cellular biology

authors： Kulshreshtha R,Ferracin M,Wojcik SE,Garzon R,Alder H,Agosto-Perez FJ,Davuluri R,Liu CG,Croce CM,Negrini M,Calin GA,Ivan M

更新日期：2007-03-01 00:00:00

abstract：:Unique single-stranded regions of simian virus 40 DNA, phage M13 virion DNA, and several homopolymers were used as templates for the synthesis of (p)ppRNA-DNA chains by CV-1 cell DNA primase-DNA polymerase alpha. Intact RNA primers, specifically labeled with an RNA capping enzyme, were typically 6 to 8 ribonucleotides...

journal_title：Molecular and cellular biology

authors： Yamaguchi M,Hendrickson EA,DePamphilis ML

更新日期：1985-05-01 00:00:00

abstract：:Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear translocation and the assembly of a transcriptional complex in which ErbB-2 acts as a coactivator o...

journal_title：Molecular and cellular biology

authors： Béguelin W,Díaz Flaqué MC,Proietti CJ,Cayrol F,Rivas MA,Tkach M,Rosemblit C,Tocci JM,Charreau EH,Schillaci R,Elizalde PV

更新日期：2010-12-01 00:00:00

abstract：:The homeobox gene HOXA9 has recently been shown to be an important regulator of endothelial cell (EC) differentiation and activation in addition to its role in embryonic development and hematopoiesis. In this report, we have determined that the EC-leukocyte adhesion molecule E-selectin is a key target for HOXA9. The d...

journal_title：Molecular and cellular biology

authors： Bandyopadhyay S,Ashraf MZ,Daher P,Howe PH,DiCorleto PE

更新日期：2007-06-01 00:00:00

abstract：:Extinction of phosphoenolpyruvate carboxykinase (PCK) gene expression in hepatoma x fibroblast hybrids is mediated by a trans-acting genetic locus designated tissue-specific extinguisher 1 (TSE1). To identify PCK gene sequences required for extinction, hepatoma transfectants expressing PCK-thymidine kinase (TK) chimer...

journal_title：Molecular and cellular biology

authors： Thayer MJ,Lugo TG,Leach RJ,Fournier RE

更新日期：1990-06-01 00:00:00

abstract：:Wnt signaling plays an important role in the regulation of bone formation and bone mass. The mechanisms that regulate canonical Wnt signaling in osteoblasts are not fully understood. We show here a novel mechanism by which the adhesion molecule N-cadherin interacts with the Wnt coreceptor LRP5 and regulates canonical ...

journal_title：Molecular and cellular biology

authors： Haÿ E,Laplantine E,Geoffroy V,Frain M,Kohler T,Müller R,Marie PJ

更新日期：2009-02-01 00:00:00

abstract：:In vertebrates, the basic helix-loop-helix (bHLH) protein Twist may be involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis. Although it has been shown that mouse twist (M-Twist) (i) sequesters E proteins, thu...

journal_title：Molecular and cellular biology

authors： Hamamori Y,Wu HY,Sartorelli V,Kedes L

更新日期：1997-11-01 00:00:00

abstract：:Fusions between the TRM1 gene of Saccharomyces cerevisiae and COXIV or DHFR were made to examine the mitochondrial targeting signals of N2,N2-dimethylguanosine-specific tRNA methyltransferase [tRNA (m2(2)G)dimethyltransferase]. This enzyme is responsible for the modification of both mitochondrial and cytoplasmic tRNAs...

journal_title：Molecular and cellular biology

authors： Ellis SR,Hopper AK,Martin NC

更新日期：1989-04-01 00:00:00

abstract：:Previously, we described a retrovirus vector that contained two genes: a 5' gene under transcriptional control of the viral long terminal repeat and a 3' gene under transcriptional control of the herpes simplex virus thymidine kinase promoter. By using a biological assay, we found that expression of the 5' gene is sup...

journal_title：Molecular and cellular biology

authors： Emerman M,Temin HM

更新日期：1986-03-01 00:00:00

abstract：:Activation of canonical Wnt signaling inhibits brown adipogenesis of cultured cells by impeding induction of PPARgamma and C/EBPalpha. Although enforced expression of these adipogenic transcription factors restores lipid accumulation and expression of FABP4 in Wnt-expressing cells, additional expression of PGC-1alpha ...

journal_title：Molecular and cellular biology

authors： Kang S,Bajnok L,Longo KA,Petersen RK,Hansen JB,Kristiansen K,MacDougald OA

更新日期：2005-02-01 00:00:00

abstract：:The Saccharomyces cerevisiae Trf4 and Trf5 proteins are members of a distinct family of eukaryotic DNA polymerase beta-like nucleotidyltransferases, and a template-dependent DNA polymerase activity has been reported for Trf4. To define the nucleotidyltransferase activities associated with Trf4 and Tr5, we purified the...

journal_title：Molecular and cellular biology

authors： Haracska L,Johnson RE,Prakash L,Prakash S

更新日期：2005-11-01 00:00:00

abstract：:The chicken immunoglobulin light-chain gene (IgL) encodes only a single variable gene segment capable of recombination. To generate an immune repertoire, chickens diversify this unique rearranged VL gene segment during B-cell development in the bursa of Fabricius. Sequence analysis of IgL cDNAs suggests that both gene...

journal_title：Molecular and cellular biology

authors： Kim S,Humphries EH,Tjoelker L,Carlson L,Thompson CB

更新日期：1990-06-01 00:00:00