Abstract:
:The prion protein Met129Val polymorphism has recently been related to human long-term memory with carriers of either the 129MM or the 129MV genotype recalling 17% more words than 129(VV) carriers at 24h following learning. Here, we sampled genotype differences in retrieval-related brain activity at 30min and 24h following learning. Furthermore, genotype groups were compared regarding grey matter concentrations and cognitive profiles. We used event-related functional magnetic resonance imaging (fMRI) during a word recognition task on 12 Met/Met carriers, 12 Val/Met carriers, and 12 Val/Val carriers. These groups were matched for retrieval performance, gender, age, education, and other memory-related genetic polymorphisms. Although retrieval performance was matched, Val carriers exhibited enhanced retrieval-related brain activity at 30min and 24h following learning. At both time lags, correlations between retrieval-related brain activity and retrieval success were negative for Val homozygotes (the more activity, the worse retrieval success), while correlations showed no significance or were positive for Met homozygotes and heterozygotes. These results suggest a less economic use of retrieval-related neural resources in Val relative to Met carriers. Furthermore, Val carriers exhibited higher neocortical grey matter concentrations compared to Met carriers. When controlling for grey matter concentration, genotype effects in retrieval-related brain activity remained significant. Val and Met carriers yielded comparable brain activations for correct rejections of non-studied words and for working memory, which speaks to the specificity of the genotype effect. Findings suggest that the prion protein Met129Val polymorphism affects neural plasticity following learning at a time-scale of minutes to hours.
journal_name
Neuropsychologiajournal_title
Neuropsychologiaauthors
Buchmann A,Mondadori CR,Hänggi J,Aerni A,Vrticka P,Luechinger R,Boesiger P,Hock C,Nitsch RM,de Quervain DJ,Papassotiropoulos A,Henke Kdoi
10.1016/j.neuropsychologia.2008.03.002subject
Has Abstractpub_date
2008-01-01 00:00:00pages
2389-402issue
9eissn
0028-3932issn
1873-3514pii
S0028-3932(08)00096-1journal_volume
46pub_type
杂志文章相关文献
NEUROPSYCHOLOGIA文献大全abstract::Human can easily detect other's eyes and gaze from early in life. Such sensitivity is supported by the contrast polarity of human eyes, which have a white sclera contrasting with the darker colored iris (Kobayashi & Kohshima, (1997). Nature, 387, 767-768; Kobayashi & Kohshima, (2001). Journal of Human Evolution, 40, 4...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.08.020
更新日期:2013-11-01 00:00:00
abstract::A Famous Faces Test designed to assess face recognition, spontaneous naming, verbal identification of un-named faces, and cued naming using semantic and phonetic cues was administered to 22 patients with dementia of Alzheimer type (DAT) and 25 matched controls. The DAT patients were significantly impaired in all test ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(93)90128-m
更新日期:1993-08-01 00:00:00
abstract::Researchers have examined how parenting behavior influences individuals' brain structure and behavioral development, primarily among people who have experienced maltreatment. However, information relating to the anatomical structure associated with the parenting behavior in young healthy individuals who have not exper...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2017.12.017
更新日期:2018-01-31 00:00:00
abstract::Tactual extinction was examined in a 43-yr-old left-handed male patient (MM) with a hematoma in the trunk of the corpus callosum sparing the genu and the ventral part of the splenium as well as the cerebral hemispheres. Experiments I and II showed no deficit in tactual perception nor in the inter-hemispheric transfer ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(88)90054-1
更新日期:1988-01-01 00:00:00
abstract::The current study used fMRI to explore the extent to which neural activation patterns in the processing of speech are driven by the quality of a speech sound as a member of its phonetic category, that is, its category typicality, or by the competition inherent in resolving the category membership of stimuli which are ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2006.11.005
更新日期:2007-04-08 00:00:00
abstract::Monkeys with crossed unilateral excitotoxic lesions of the anterior thalamus and unilateral inferotemporal cortex ablation were severely impaired at learning two tasks which required the integration of information about the appearance of objects and their positions in space. The lesioned monkeys were also impaired at ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2004.02.005
更新日期:2004-01-01 00:00:00
abstract::A number of previous studies have implicated regions in posterior auditory cortex (AC) in auditory-motor integration during speech production. Other studies, in turn, have shown that activation in AC and adjacent regions in the inferior parietal lobule (IPL) is strongly modulated during active listening and depends on...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2018.11.006
更新日期:2019-02-18 00:00:00
abstract::A number of studies have reported correlations between subjects' asymmetry scores on left and right hemisphere specialized tasks. In this paper we report the results of meta-analyses performed on these correlations. Results showed positive correlations between subjects' asymmetry scores on left and right hemisphere sp...
journal_title:Neuropsychologia
pub_type: 杂志文章,meta分析
doi:10.1016/0028-3932(91)90053-b
更新日期:1991-01-01 00:00:00
abstract::Event-related brain potentials (ERPs) were recorded while subjects determined whether two sequentially presented famous faces depicted individuals belonging to the same or to different occupational categories. During the 1.56 sec interval between the onset of the faces, ERPs recorded from right hemisphere electrodes w...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(89)90067-5
更新日期:1989-01-01 00:00:00
abstract::The detection of social threat is crucial for adaptive behaviour. Previous studies have shown that angry faces capture attention and are processed more efficiently than happy faces. While this anger superiority effect has been found in typical and atypical development, it is unknown whether it exists in individuals wi...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2009.12.006
更新日期:2010-03-01 00:00:00
abstract::Intentions are commonly conceived of as discrete mental states that are the direct cause of actions. In the last several decades, neuroscientists have taken up the project of finding the neural implementation of intentions, and a number of areas have been posited as implementing these states. We argue, however, that t...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/j.neuropsychologia.2014.01.010
更新日期:2014-04-01 00:00:00
abstract::Induced gamma-band response (iGBR) has been linked to coherent perception of images and is thought to represent the synchronisation of neuronal populations mediating binding of elements composing the image and the comparisons with memory for proper recognition. This study uses fragmented images with intracranial elect...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.01.002
更新日期:2013-03-01 00:00:00
abstract::Recognizing unfamiliar faces is more difficult than familiar face recognition, and this has been attributed to qualitative differences in the processing of familiar and unfamiliar faces. Familiar faces are assumed to be represented by view-independent codes, whereas unfamiliar face recognition depends mainly on view-d...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.03.028
更新日期:2013-06-01 00:00:00
abstract::In this paper we report findings which question the diagnosis of a hemianopia in B.Q., a 66-year-old lady who shows unilateral spatial neglect following a lesion to the right parietal lobe. The presence of a hemianopia has been indicated following two independent assessments of B.Q.'s visual fields. We examined B.Q.'s...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90065-g
更新日期:1991-01-01 00:00:00
abstract::Memory impairment was demonstrated in a sample of 46 children and adolescents with brain tumors. The overall distribution of memory scores was skewed positively; over half of the total number of test measures were in the lowest quarter of the score distribution; and more than three-quarters of the individual subjects ...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(91)90049-e
更新日期:1991-01-01 00:00:00
abstract::Patients with visual field disorders often exhibit impairments in visual exploration and a typical defective oculomotor scanning behaviour. Recent evidence [Bolognini, N., Rasi, F., Coccia, M., & Làdavas, E. (2005b). Visual search improvement in hemianopic patients after audio-visual stimulation. Brain, 128, 2830-2842...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2008.10.008
更新日期:2009-01-01 00:00:00
abstract::The contribution of each cerebral hemisphere to the generation of semantic category meanings at automatic and strategic levels of processing was investigated in a priming experiment where prime and target words were independently projected to the left or right visual fields (LVF or RVF). Non-associated category exempl...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/s0028-3932(98)00156-0
更新日期:1999-08-01 00:00:00
abstract::This is a prospective neuropsychological study on face processing in Alzheimer's disease (AD). The aim was to assess the prevalence and the nature of face processing disorders in AD, and at investigating possible inter-test dissociations within the framework of currently used face processing models. A standardized fou...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/0028-3932(95)00009-r
更新日期:1995-06-01 00:00:00
abstract::Cognitive impairment in Parkinson's disease (PD) is often attributed to dopamine deficiency in the prefrontal-basal ganglia-thalamo-cortical loops. Although recent studies point to a close interplay between motor and cognitive abilities in PD, the so-called "motor loop" connecting supplementary motor area (SMA) and pu...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2015.09.017
更新日期:2015-10-01 00:00:00
abstract::Groups of patients with Parkinson's disease, either medicated or unmedicated, were compared with a matched group of normal control subjects on a computerized battery of tests designed to assess spatial, verbal and visual working memory. In the spatial working memory task, subjects were required to search systematicall...
journal_title:Neuropsychologia
pub_type: 临床试验,杂志文章
doi:10.1016/s0028-3932(96)00101-7
更新日期:1997-04-01 00:00:00
abstract::Previous behavioral studies have shown that individuals with autism are less hindered by interference from global processing during the performance of lower-level perceptual tasks, such as finding embedded figures. The primary goal of this study was to examine the brain manifestation of such atypicality in high-functi...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.04.005
更新日期:2011-06-01 00:00:00
abstract::Two right-handed patients with infarction involving the forebrain commissural fibres produced irregular but rapid repetitive movements with their left hands while producing normal movements with their right hands as well as having normal oral expression. The abnormality was more conspicuous when producing slow tapping...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(89)90004-3
更新日期:1989-01-01 00:00:00
abstract::Although substantive understanding of brain dysfunction in autism remains meager, clinical evidence as well as animal brain research on the effects of early damage to selective brain system have now yielded enough knowledge that some provisional hypotheses concerning the etiology of autism can be generated. Basically,...
journal_title:Neuropsychologia
pub_type: 杂志文章,评审
doi:10.1016/0028-3932(94)90025-6
更新日期:1994-06-01 00:00:00
abstract::For native speakers, many studies suggest a link between oscillatory neural activity in the beta frequency range and syntactic processing. For late second language (L2) learners on the other hand, the extent to which the neural architecture supporting syntactic processing is similar to or different from that of native...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2016.06.031
更新日期:2016-08-01 00:00:00
abstract::Previous non-invasive studies have proposed that the deeply seated region of the medial frontal cortex engages in conflict processing in humans, but its core region has remained to be elucidated. By means of direct cortical stimulation, which excels other techniques in temporal and spatial resolutions and in the capac...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2013.02.002
更新日期:2013-04-01 00:00:00
abstract::The magnitude dimensions of number, time and space have been suggested to share some common magnitude processing, which may imply symmetric interaction among dimensions. Here we challenge these suggestions by presenting a double dissociation between two neuropsychological patients with left (JT) and right (CB) parieta...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2011.07.014
更新日期:2011-09-01 00:00:00
abstract::Humans typically make several rapid eye movements (saccades) per second. It is thought that visual working memory can retain and spatially integrate three to four objects or features across each saccade but little is known about this neural mechanism. Previously we showed that transcranial magnetic stimulation (TMS) t...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2014.08.025
更新日期:2014-10-01 00:00:00
abstract::In an earlier study by Parkinson et al. (J. Neurosci. 8, 4159-4167, 1988), hippocampectomized monkeys were found to be impaired on a task in which they were required to remember the spatial positions of trial-unique objects overlying two of the wells in a three-well test tray. There were two types of trial in the task...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/0028-3932(93)90030-4
更新日期:1993-10-01 00:00:00
abstract::Recent research posits that the cognitive system samples target stimuli in a rhythmic fashion, characterized by target detection fluctuating at frequencies of ~3-8 Hz. Besides prioritized encoding of targets, a key cognitive function is the protection of working memory from distractor intrusion. Here, we test to which...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2020.107505
更新日期:2020-09-01 00:00:00
abstract::In general, declarative learning is associated with the activation of the medial temporal lobes (MTL), while the basal ganglia (BG) are considered the substrate for procedural learning. More recently it has been demonstrated the distinction of these systems may not be as absolute as previously thought and that not onl...
journal_title:Neuropsychologia
pub_type: 杂志文章
doi:10.1016/j.neuropsychologia.2012.05.021
更新日期:2012-07-01 00:00:00