Axial pressure gradient in the canine superior vena cava.

abstract：AIMS:Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic cardiomyopathy. However, the underlying mechanisms remain not fully understood. MicroRNAs (miRNAs) are non-coding small RNAs that control gene expression at the post-transcriptional level. Dysregulated miRNAs have been shown to b...

journal_title：Cardiovascular research

authors： Zhu H,Yang Y,Wang Y,Li J,Schiller PW,Peng T

更新日期：2011-10-01 00:00:00

abstract：AIMS:Aortic adaptive immunity plays a role in atherosclerosis; however, the precise mechanisms leading to T-cell activation in the arterial wall remain poorly understood. METHODS AND RESULTS:Here, we have identified naïve T cells in the aorta of wild-type and T-cell receptor transgenic mice and we demonstrate that naï...

journal_title：Cardiovascular research

authors： MacRitchie N,Grassia G,Noonan J,Cole JE,Hughes CE,Schroeder J,Benson RA,Cochain C,Zernecke A,Guzik TJ,Garside P,Monaco C,Maffia P

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:There is accumulating evidence that oestrogen replacement therapy protects against the development of coronary atherosclerosis and myocardial infarction in postmenopausal women. The mechanism of this protective effect is uncertain. The aim of this study was to measure the effects of 17 beta-oestradiol on huma...

journal_title：Cardiovascular research

authors： Mügge A,Riedel M,Barton M,Kuhn M,Lichtlen PR

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVE:Atrial (ANP) and B-type natriuretics peptides (BNP) via their guanylyl cyclase-A (GC-A) receptor not only regulate arterial blood pressure and volume but also exert local antihypertrophic, antifibrotic and lusitropic effects in the heart. To elucidate whether cardiac hypertrophy/insufficiency and reversal is ...

journal_title：Cardiovascular research

authors： Kuhn M,Voss M,Mitko D,Stypmann J,Schmid C,Kawaguchi N,Grabellus F,Baba HA

更新日期：2004-11-01 00:00:00

abstract：AIMS:Anthracycline-induced cardiotoxicity (AIC) is a serious adverse effect among cancer patients. A central mechanism of AIC is irreversible mitochondrial damage. Despite major efforts, there are currently no effective therapies able to prevent AIC. METHODS AND RESULTS:Forty Large-White pigs were included. In Study 1...

journal_title：Cardiovascular research

authors： Galán-Arriola C,Villena-Gutiérrez R,Higuero-Verdejo MI,Díaz-Rengifo IA,Pizarro G,López GJ,de Molina-Iracheta A,Pérez-Martínez C,García RD,González-Calle D,Lobo M,Sánchez PL,Oliver E,Córdoba R,Fuster V,Sánchez-González J,I

更新日期：2020-06-29 00:00:00

abstract：OBJECTIVE:Previous studies showed that treatment of hearts with nisoldipine improves recovery of cardiac function following ischaemia, improves reperfusion, and reduces the constrictor sensitivity to endothelin. The aim of the present study was to assess the reduction in vasodilator responses that occurs following isch...

journal_title：Cardiovascular research

authors： Yaghi MM,Watts JA

更新日期：1993-06-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate the effect of lowering external potassium on the sensitivity of the normal and hypertrophied rat heart to arrhythmias induced by increases in ventricular wall stress. METHODS:The isolated working heart model was used to compare hypertrophied hearts from the spontaneously hypertensi...

journal_title：Cardiovascular research

authors： Evans SJ,Levi AJ,Jones JV

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:Left ventricular assist devices (LVAD) have been used to 'bridge' patients with end-stage heart failure to transplantation. Although several reports have suggested that the native ventricular function recovers after long-term LVAD support, a process called 'reverse remodeling', the underlying biological mecha...

journal_title：Cardiovascular research

authors： Grabellus F,Levkau B,Sokoll A,Welp H,Schmid C,Deng MC,Takeda A,Breithardt G,Baba HA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To investigate the physiological role of cAMP-dependent protein kinase A (PKA)-mediated, cardiac myosin binding protein C (MyBP-C) phosphorylation. METHODS:A cardiac MyBP-C cDNA lacking nine amino acids, which contained a phosphorylation site, was made, and subsequently used to generate multiple lines of tra...

journal_title：Cardiovascular research

authors： Yang Q,Hewett TE,Klevitsky R,Sanbe A,Wang X,Robbins J

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVES:Action potential prolongation related to the alteration of several membrane currents is constantly reported in heart failure (HF) but reports about its role in arrhythmogenesis are sparse. Our aim was to determine, by analogy with long QT syndromes, whether prolonged repolarization is associated with increas...

journal_title：Cardiovascular research

authors： Lacroix D,Gluais P,Marquié C,D'Hoinne C,Adamantidis M,Bastide M

更新日期：2002-04-01 00:00:00

abstract：AIMS:The heart contains c-kit(+) progenitors that maintain cardiac homeostasis. Cardiac c-kit(+) cells are multipotent and give rise to myocardial, endothelial and smooth muscle cells, both in vitro and in vivo. C-kit(+) cells have been thoroughly investigated for their stem cell activity, susceptibility to stress cond...

journal_title：Cardiovascular research

authors： Gambini E,Pompilio G,Biondi A,Alamanni F,Capogrossi MC,Agrifoglio M,Pesce M

更新日期：2011-02-01 00:00:00

abstract：AIMS:The aim of this work was to use hyperpolarized carbon-13 ((13)C) magnetic resonance (MR) spectroscopy and cine MR imaging (MRI) to assess in vivo cardiac metabolism and function in the 15-week-old spontaneously hypertensive rat (SHR) heart. At this time point, the SHR displays hypertension and concentric hypertrop...

journal_title：Cardiovascular research

authors： Dodd MS,Ball DR,Schroeder MA,Le Page LM,Atherton HJ,Heather LC,Seymour AM,Ashrafian H,Watkins H,Clarke K,Tyler DJ

更新日期：2012-07-01 00:00:00

abstract：AIMS:The angiotensin II type 1 receptor (AT1R) through the activation of immune cells plays a key role in arterial inward remodelling and reduced blood flow in cardiovascular disorders. On the other side, flow (shear stress)-mediated outward remodelling (FMR), involved in collateral arteries growth in ischaemic disease...

journal_title：Cardiovascular research

authors： Caillon A,Grenier C,Grimaud L,Vessieres E,Guihot AL,Blanchard S,Lelievre E,Chabbert M,Foucher ED,Jeannin P,Beauvillain C,Abraham P,Loufrani L,Delneste Y,Henrion D

更新日期：2016-10-01 00:00:00

abstract：:Tension and action potentials have been measured simultaneously from isolated cat papillary muscles. Two groups of experiments are described. In the first group, the external conditions under which the muscle contracted were changed. Specifically, stimulation rate, extra-cellular [Ca++], extracellular [Na++] were alte...

journal_title：Cardiovascular research

authors： Allen DG

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to determine whether exercise training could precondition the myocardium against hydrogen peroxide (H(2)O(2))-induced damage. METHODS:Male Fischer 344 rats ran on a treadmill for 9 weeks (60 min/day, 22 m/min, 6 degrees grade, 5 days/week). Isolated perfused working hearts from ...

journal_title：Cardiovascular research

authors： Taylor RP,Ciccolo JT,Starnes JW

更新日期：2003-06-01 00:00:00

abstract：:The failing heart is characterized by alterations in energy metabolism, including mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially compensated by an increase in glucose utilization. Together, these changes lead to an impaired capacity to convert chemical energy into mecha...

journal_title：Cardiovascular research

authors： van Bilsen M,van Nieuwenhoven FA,van der Vusse GJ

更新日期：2009-02-15 00:00:00

abstract：AIM:Atrial fibrosis, one of the most striking features in the pathology of atrial fibrillation (AF), is promoted by local and systemic inflammation. Electrophilic fatty acid nitroalkenes, endogenously generated by both metabolic and inflammatory reactions, are anti-inflammatory mediators that in synthetic form may be u...

journal_title：Cardiovascular research

authors： Rudolph TK,Ravekes T,Klinke A,Friedrichs K,Mollenhauer M,Pekarova M,Ambrozova G,Martiskova H,Kaur JJ,Matthes B,Schwoerer A,Woodcock SR,Kubala L,Freeman BA,Baldus S,Rudolph V

更新日期：2016-01-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to compare platelet function in diabetic and non-diabetic survivors of acute myocardial infarction and to relate it to an index of free radical activity in these patients. DESIGN:In vivo and in vitro indices of platelet function and diene conjugate molar ratios were measured in diabetic and...

journal_title：Cardiovascular research

authors： Hendra TJ,Wickens DG,Dormandy TL,Yudkin JS

更新日期：1991-08-01 00:00:00

abstract：AIMS:A problem in generating artificial tissues is supplying nutrients to cells within 3D constructs. The use of a decellularized biological vascularized matrix with preserved pedicles (BioVaM), as a scaffold, appears to aid the generation of perfusable tissue constructs in vitro. To prevent vessel occlusion upon impla...

journal_title：Cardiovascular research

authors： Bär A,Dorfman SE,Fischer P,Hilfiker-Kleiner D,Cebotari S,Tudorache I,Suprunov M,Haverich A,Hilfiker A

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:It has been shown that cGMP content is reduced in post-ischemic myocardium, and that stimulation of cGMP synthesis prevents cardiomyocyte hypercontracture and cell death in vitro. This study was aimed at determining whether administration of the natriuretic peptide urodilatin (URO) at the time of reperfusion ...

journal_title：Cardiovascular research

authors： Padilla F,Garcia-Dorado D,Agulló L,Barrabés JA,Inserte J,Escalona N,Meyer M,Mirabet M,Pina P,Soler-Soler J

更新日期：2001-08-15 00:00:00

abstract：OBJECTIVE:Oxidized low-density lipoprotein (ox-LDL) increases superoxide anion (O(2)(-)) production by the endothelial nitric oxide (NO) synthase (eNOS). We assessed whether the uncoupling of eNOS was associated with alterations in eNOS phosphorylation and/or the assembly of the eNOS signaling complex. METHODS AND RES...

journal_title：Cardiovascular research

authors： Fleming I,Mohamed A,Galle J,Turchanowa L,Brandes RP,Fisslthaler B,Busse R

更新日期：2005-03-01 00:00:00

abstract：:Severe sepsis and septic shock, which are among the most common causes of death in intensive care units worldwide, cause high morbidity, mortality, and social and economic costs. Therefore, developing successful therapies against sepsis is one of the most important challenges in critical care medicine. Death from sept...

journal_title：Cardiovascular research

authors： Cauwels A,Brouckaert P

更新日期：2011-02-15 00:00:00

abstract：OBJECTIVES:Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-)). METHODS:Nineteen adult annexin A7(-/-) and 14 wild-type m...

journal_title：Cardiovascular research

authors： Schrickel JW,Brixius K,Herr C,Clemen CS,Sasse P,Reetz K,Grohé C,Meyer R,Tiemann K,Schröder R,Bloch W,Nickenig G,Fleischmann BK,Noegel AA,Schwinger RH,Lewalter T

更新日期：2007-11-01 00:00:00

abstract：AIMS:It is well established that leukotrienes (LTs), products of the 5-lipoxygenase (5-LO) pathway, participate in inflammatory tissue reactions and immune responses. In the present study, the impact of the 5-LO pathway on vasculogenesis of mouse embryonic stem (ES) cells was investigated. METHODS AND RESULTS:Immunohi...

journal_title：Cardiovascular research

authors： Finkensieper A,Kieser S,Bekhite MM,Richter M,Mueller JP,Graebner R,Figulla HR,Sauer H,Wartenberg M

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVE:To study the intracellular pathways which mediate the inhibitory actions of adenosine on isoprenaline-stimulated calcium current (ICa) in atrioventricular (AV) nodal myocytes. METHODS:The whole-cell patch-clamp technique was used to record ICa from rabbit AV nodal cells, isolated by enzymatic and mechanical ...

journal_title：Cardiovascular research

authors： Martynyuk AE,Kane KA,Cobbe SM,Rankin AC

更新日期：1997-05-01 00:00:00

abstract：:The last decade has seen a dramatic increase in the understanding of the molecular basis of arrhythmias. Much of this new information has been driven by genetic studies that focused on rare, monogenic arrhythmia syndromes that were accompanied or followed by cellular electrophysiological or biochemical studies. The ma...

journal_title：Cardiovascular research

authors： Kääb S,Schulze-Bahr E

更新日期：2005-08-15 00:00:00

abstract：AIMS:Thromboxane A2 (TXA2) induces platelet adhesion through thromboxane prostanoid (TP) receptor. Platelets contain many pro-angiogenic factors and are recruited to the site of vascular injury. However, the cellular and molecular mechanisms of platelet-dependent angiogenesis, especially the involvement of TP signallin...

journal_title：Cardiovascular research

authors： Amano H,Ito Y,Eshima K,Kato S,Ogawa F,Hosono K,Oba K,Tamaki H,Sakagami H,Shibuya M,Narumiya S,Majima M

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Air bubbles entering the coronary artery may have harmful effects on cardiac function. From the physical point of view it is the relatively high surface tension of the blood-air interface which causes bubbles to trap in small vessels. The aim of the present study was to reduce depression of myocardial functio...

journal_title：Cardiovascular research

authors： van Blankenstein JH,Slager CJ,Soei LK,Boersma H,Stijnen T,Schuurbiers JC,Krams R,Lachmann B,Verdouw PD

更新日期：1997-06-01 00:00:00

abstract：AIMS:Our previous studies demonstrated that inflammation contributes to atherosclerosis through disruption of the low density lipoprotein receptor (LDLr) pathway. However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR ...

journal_title：Cardiovascular research

authors： Ma KL,Liu J,Wang CX,Ni J,Zhang Y,Wu Y,Lv LL,Ruan XZ,Liu BC

更新日期：2013-12-01 00:00:00

abstract：STUDY OBJECTIVE:The aim was to quantify the changes in placental blood flow and combined ventricular output with gestational age in normal human fetuses to determine the percentage of total cardiac output that placental blood flow represented, and whether this changed with age. DESIGN:Two dimensional echocardiographic...

journal_title：Cardiovascular research

authors： Sutton MG,Plappert T,Doubilet P

更新日期：1991-07-01 00:00:00