Abstract:
:At an ever increasing pace, synthetic biomaterials are being developed with specific functionalities for tissue engineering applications. These biomaterials possess properties including biocompatibility, mechanical strength, and degradation as well as functionalities such as specific cell adhesion and directed cell migration. However, synthetic polymers are often not completely biologically inert and may non-specifically react with the surrounding in vivo environment. An example of this reactivity is the release of acidic degradation products from hydrolytically degradable polymers based upon an ester moiety. In order to address this concern, a novel class of biomaterials based upon a cyclic acetal unit has been developed. Scaffolds suitable for the replacement of both hard and soft tissues have been successfully fabricated from cyclic acetals and a detailed characterization of scaffold properties has been performed. Cyclic acetal based biomaterials have also been used to repair bone defects and promote bone growth, displaying a minimal inflammatory response. This review will discuss the most recent research of current biomaterials and cyclic acetals, and particularly focus on the tissue engineering applications of these materials. Finally, this review will also briefly discuss polyacetals and polyketals for drug delivery applications.
journal_name
Pharm Resjournal_title
Pharmaceutical researchauthors
Falco EE,Patel M,Fisher JPdoi
10.1007/s11095-008-9620-5subject
Has Abstractpub_date
2008-10-01 00:00:00pages
2348-56issue
10eissn
0724-8741issn
1573-904Xjournal_volume
25pub_type
杂志文章,评审abstract::The synthesis of an homologous series of new water-soluble derivatives of pilocarpine is described. The new compounds, referred to as soft quaternary salts, are water soluble by virtue of a cationic ammonium head and their lipophilicity can be modulated by manipulating the size and the nature of the substituent in the...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015847103862
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015985511653
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abstract::Liver fibrosis is a pathological condition originating from liver damage that leads to excess accumulation of extracellular matrix (ECM) proteins in the liver. Viral infection, chronic injury, local inflammatory responses and oxidative stress are the major factors contributing to the onset and progression of liver fib...
journal_title:Pharmaceutical research
pub_type: 杂志文章,评审
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-008-9704-2
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015978704810
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1016416413780
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1012051300130
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1018962415287
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-005-2591-x
更新日期:2005-05-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-004-1872-0
更新日期:2005-03-01 00:00:00
abstract::The transport of thyrotropin releasing hormone (TRH) in rabbit buccal mucosa in vitro has been investigated with respect to (a) rate and type of metabolism of TRH on mucosal and serosal sides of buccal mucosa, (b) mechanism of TRH transport including charge effect on its permeability, and (c) pathway and rate-limiting...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015883217858
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abstract::Sodium taurodihydrofusidate (STDHF) is one of the most promising absorption enhancers for nasal delivery of peptide drugs. Drugs and additives in nasal formulations should not interfere with the self-cleaning capacity of the nose by the ciliary epithelium. Measured in vitro on human adenoid tissue with a photoelectric...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015872617511
更新日期:1990-02-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1018901325842
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journal_title:Pharmaceutical research
pub_type: 杂志文章
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更新日期:2008-05-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-006-9230-z
更新日期:2007-06-01 00:00:00
abstract:PURPOSE:Long-acting injectables (LAIs) are increasingly recognized as an effective therapeutic approach for treating chronic conditions. Many LAIs are formulated to create a poorly soluble depot from which the active agent is delivered over time. This long residing depot can cause localized chronic-active inflammation ...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1007/s11095-014-1308-4
更新日期:2014-08-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1019894008885
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:2004-01-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015889707922
更新日期:1992-05-01 00:00:00
abstract:PURPOSE:Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. METHODS:The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum c...
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:2007-05-01 00:00:00
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journal_title:Pharmaceutical research
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journal_title:Pharmaceutical research
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更新日期:2016-08-01 00:00:00
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journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/a:1015880327911
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abstract::The fluxes of nitroglycerine (NG) through human abdominal epidermis from different individuals were measured in vitro at 32°C. The mean NG flux for the entire group was 16.9 µg/cm(2) × hr, with a standard deviation of 47.7%. There are no significant differences in the means and the variances of NG fluxes between males...
journal_title:Pharmaceutical research
pub_type: 杂志文章
doi:10.1023/A:1016381017357
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