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The legacy of domestication: accumulation of deleterious mutations in the dog genome.

Abstract：

:Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf. We compared variation in dog and wolf genes using whole-genome single nucleotide polymorphism (SNP) data. The d(N)/d(S) ratio (omega) was around 50% greater for SNPs found in dogs than in wolves, indicating that a higher proportion of nonsynonymous alleles segregate in dogs compared with nonfunctional genetic variation. We suggest that the majority of these alleles are slightly deleterious and that two main factors may have contributed to their increase. The first is a relaxation of selective constraint due to a population bottleneck and altered breeding patterns accompanying domestication. The second is a reduction of effective population size at loci linked to those under positive selection due to Hill-Robertson interference. An increase in slightly deleterious genetic variation could contribute to the prevalence of disease in modern dog breeds.

journal_name

Mol Biol Evol

journal_title

Molecular biology and evolution

authors

Cruz F,Vilà C,Webster MT

doi

10.1093/molbev/msn177

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

2331-6

issue

11

eissn

0737-4038

issn

1537-1719

pii

msn177

journal_volume

25

pub_type

杂志文章

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